The power of truth reinforced with the light of knowledge is insuperable. J.A. Comenius.

Degree programme objectives

The aim of the study program is to prepare an independent pharmacologist in the field of experimental, translation, reversal or applied clinical research, or alternatively, independent academic who will apply his / her knowledge and experience in the field of education.

The results of the dissertation are published in excerpted journals and presented in professional forums.

Entry Requirements for Candidates

Completed Master's degree in fields related to the pharmacological research on:

Medical faculty or Pharmaceutical or Veterinary faculty or faculty or university disciplines: Biochemistry, Molecular Biology, Psychology, or Zoology - with obligatory additional study and successful examination of human pathological physiology.

Suggested topics of the dissertation:

Determination of expression of the brain neurotransmitter receptors in an animal model of addiction to psychotropic substances

Changes in the receptor systems of the brain under the influence of a substance dependence

Reactivity of brain neurotransmitter systems on selected antidepressants

Effects of selected antipsychotics in behavioural animal models

Effects of cannabinoid system ligands in animal models in vivo

Effects of modulators of activity of endocannabinoid system in animal models in vivo

The role of glutamatergic system in animal model of comorbidity of depression and drug dependence

The impact of genetic polymorphism of cytochromes P450 in pharmacotherapy

Modulation of the cytochrome P450 function by endocannabinoid system

The influence of pharmacokinetic factors on the efficacy and safety of pharmacotherapy including therapeutic drug monitoring

Pharmacoeconomics, Evaluation of health technologies, e-Health

Drug regulation in clinical trials, pharmacovigilance, pricing and reimbursement of medicines

Research in the area of Advanced Therapy Medicinal Products with special focus on somatic cell therapy

Study plans

Studies

  • Objectives

    The aim of the study program is to prepare an independent pharmacologist in the field of experimental, translation, reversal or applied clinical research, or alternatively, independent academic who will apply his / her knowledge and experience in the field of education.

    The results of the dissertation are published in excerpted journals and presented in professional forums.

    Entry Requirements for Candidates

    Completed Master's degree in fields related to the pharmacological research on:

    Medical faculty or Pharmaceutical or Veterinary faculty or faculty or university disciplines: Biochemistry, Molecular Biology, Psychology, or Zoology - with obligatory additional study and successful examination of human pathological physiology.

    Suggested topics of the dissertation:

    Determination of expression of the brain neurotransmitter receptors in an animal model of addiction to psychotropic substances

    Changes in the receptor systems of the brain under the influence of a substance dependence

    Reactivity of brain neurotransmitter systems on selected antidepressants

    Effects of selected antipsychotics in behavioural animal models

    Effects of cannabinoid system ligands in animal models in vivo

    Effects of modulators of activity of endocannabinoid system in animal models in vivo

    The role of glutamatergic system in animal model of comorbidity of depression and drug dependence

    The impact of genetic polymorphism of cytochromes P450 in pharmacotherapy

    Modulation of the cytochrome P450 function by endocannabinoid system

    The influence of pharmacokinetic factors on the efficacy and safety of pharmacotherapy including therapeutic drug monitoring

    Pharmacoeconomics, Evaluation of health technologies, e-Health

    Drug regulation in clinical trials, pharmacovigilance, pricing and reimbursement of medicines

    Research in the area of Advanced Therapy Medicinal Products with special focus on somatic cell therapy

  • Learning Outcomes

    After successfully completing his/her studies the graduate is able to:

    • understand theories, concepts and methods that represent the current trends in his / her field of dissertation
    • understand theories, concepts and methods that represent the current trends in his / her field of dissertation
    • understand theories, concepts and methods in the broader context of the general pharmacology
    • can prepare a competitive grant application for a research project
    • can interpret the results of own research and the results of research in the field in general
    • can prepare a scientific article and publish in an international scientific journal
    • can immediately enter the post-doctorate post in the Czech Republic and abroad
    • knows and follows the principles of ethics of scientific work and specific ethical issues of its specialization
    • is able to be a mentor of undergraduate or Ph.D students
  • Occupational Profiles of Graduates

    Graduates of doctoral program find application in science and research in the biomedical field, more specifically in basic experimental, molecular or clinical pharmacology disciplines. Graduates are able to work individually as researchers, are able to apply for a grant to national or even international grant agencies, to publish their results in the international scientific impacted journals, to present the results of their work at an international conferences.

    Graduates may find application as a university assistant in the field of pharmacology and related fields, may also find application in various positions (especially research, development, as a consultant) in the pharmaceutical industry).

  • Practical Training

    The PhD student (according to the Ph.D topic) works with experimental animals or other appropriate laboratory or research methods supervised by the supervisor, later also independently.

    During the course of study, the doctoral student, with the support of a supervisor, will apply for the scholarships offered for professional internships and stays relevant to the subject of the dissertation.

    According to his / her possibilities and according to his / her study plan, the doctoral student participates to a limited extent in the teaching of undergraduate students of the Faculty of Medicine.

    Compulsory Courses (minimum 3 required):

    Neuropsychopharmacology

    Behavioral pharmacology

    Animal models of CNS disorders

    Biochemistry

    Xenobiochemistry

    Specialized pharmacokinetics

    Pharmacoeconomics

    Optional common subjects and courses valid at the Faculty of Arts MU (minimum 5 entries required):

    - detailed information with annotations, lecturers, schedule and recommended literature available on the official MU LF web site: http://www.med.muni.cz/index.php?id=124

    Molecular Biology and Genetics - DSMBz01

    New Trends in Pathological Physiology - DSNTz01

    Trends in Medical Immunology - DSTIz01

    Clinical Data Analysis - DSAK051 (Course)

    Ethics of Biomedical Research - DSETz01

    Rhetoric. Culture of Interpersonal Communication - DSREz01

    Obtaining scientific information - DSVIz01 (course)

    Planning, Organization and Evaluation of Clinical Trials - DSAM051 (Course)

    Computer network user - DSUP031 (course)

    English - DSAJz01 (for Medical Pharmacology - obligatory)

  • Goals of Theses

    In the dissertation thesis the student presents the results of his work, which he / she created during his / her studies in the doctoral program. The supervisor, together with the head of the department, are responsible for providing the student with the conditions needed to meet the requirements of the doctoral program.

    The student is obligated to work on the dissertation work in close cooperation with the supervisor who approves the dissertation.

    The dissertation must contain original results, either already published or accepted for publication. If the student submits to the defense the results of the collective scientific work on which he has participated, the work must be clearly marked in the work. The attachment of the thesis must be the co-author's statement confirming the student's authorship and appreciating their share in the marked parts of the work.

    The thesis must be submitted for defense in English. The text of the dissertation must be of good quality after the formal, grammatical and stylistic aspects. The dissertation is submitted in three copies in electronic version via IS Muni.

    The dissertation thesis may also be recognized as a set of articles already published or printed or another type of publication of the work on the subject, which the student provides with a complete introduction to the subject and commentary.

    The dissertation usually includes these parts

    Title page

    Student Acknowledgments (optional)

    Student's statement on the authorship of the work (optional)

    Abstract

    Table of Content

    Introduction

    Own text of work - aims, methods, results, discussion

    Conclusion

    List of references

    List of tables (optional)

    Picture List (optional)

    List of diagrams (optional)

    List of abbreviations (optional)

    Attachments (optional)

  • Additional Information
    http://www.med.muni.cz/index.php?id=161

    Further rules and conditions of the curriculum

    Within 1 year from admission to the DSP in cooperation with the supervisor, the student presents the Branch committee for doctoral study in Pharmacology (further- “Branch committee”), other students and academic staff of the Institute of Pharmacology his project - thesis of dissertation. Branch committee then discuss with the student thesis project and methods, respectively, and proposes changes in the methodology of the project.

    During the study, the doctoral candidate will report partial results of his dissertation by presentation at both national and international conferences (for this purpose applications for the grant support are expected to be submitted).

    During the study, the doctoral student will be supported by a supervisor to apply for scholarships offered to professional internships relevant to the topic of the dissertation.

    2 years after the adoption of the DSP: obligation to present to supervisor and Branch committee a manuscript (might be a review paper), which submits for publication in scientific journals (at least Czech / Slovak scientific periodical).

    The latest in the fourth year of study, the student should present his/her own experimental results, which are suitable for publication in a journal with IF.

    Branch committee will recommend to continue only to the students who have published their own results in periodical with IF or their article was accepted for publication in a periodical with an IF (1st author). If the student fails to comply with the timeframes set rules above, Branch committee propose, after discussion with the supervisor, discontinuation or termination of the PhD studies.

    The final condition of the successful PhD student is the preparation and successful defense of a dissertation in the final year of study.

    Teaching duties in the course of Pharmacology taught at various fields at the Faculty of Medicine (in accordance with the Study Regulations MU).

    Requirements for the State Doctoral Examination of Pharmacology:

    Oral defense of knowledge within the scope of knowledge of modern pharmacology (according to the recommended literature) before at least five-member examination committee comprised of experts from MU and at least two members from other bodies (outside MU).

Basic information

Type
doctoral degree programme
Degree
Ph.D.
Length of studies
4 years
Language of instruction
Czech Czech

7
number of active students
5
number of theses/dissertations

Faculty of Medicine
Programme guaranteed by
Programme guarantor