Oxidative stress and detoxification biomarker responses in
aquatic freshwatervertebrates exposed to microcystins and
cyanobacterial biomass.

J 2012

Oxidative stress and detoxification biomarker responses in aquatic freshwatervertebrates exposed to microcystins and cyanobacterial biomass.

PASKEROVÁ, Hana, Klára HILSCHEROVÁ a Luděk BLÁHA

Základní údaje

Originální název

Oxidative stress and detoxification biomarker responses in aquatic freshwatervertebrates exposed to microcystins and cyanobacterial biomass.

Autoři

PASKEROVÁ, Hana (203 Česká republika, domácí), Klára HILSCHEROVÁ (203 Česká republika, domácí) a Luděk BLÁHA (203 Česká republika, garant, domácí)

Vydání

Environmental Science and Pollution Research, HEIDELBERG, GERMANY, SPRINGER HEIDELBERG, 2012, 0944-1344

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

10511 Environmental sciences

Stát vydavatele

Německo

Utajení

není předmětem státního či obchodního tajemství

Impakt faktor

Impact factor: 2.618

Kód RIV

RIV/00216224:14310/12:00057616

Organizační jednotka

Přírodovědecká fakulta

DOI

http://dx.doi.org/10.1007/s11356-012-0960-7

UT WoS

000306123000016

Klíčová slova anglicky

Biomarkers; Cyanobacteria; Detoxification; Fish; Oxidative stress; Microcystin

Štítky

AKR, rivok

Změněno: 11. 4. 2013 13:02, Ing. Andrea Mikešková

Anotace

V originále

Cyanobacterial blooms represent a serious threat to the aquatic environment. Among other effects, biochemical markers have been studied in aquatic vertebrates after exposures to toxic cyanobacteria. Some parameters such as protein phosphatases may serve as selective markers of exposure to microcystins, but under natural conditions, fish are exposed to complex mixtures, which affect the overall biomarker response. This review aims to provide a critical summary of biomarker responses in aquatic vertebrates (mostly fish) to toxic cyanobacteria with a special focus on detoxification and oxidative stress. Detoxification biomarkers such as glutathione (GSH) and glutathione-S-transferase (GST) showed very high variability with poor general trends. Often, stimulations and/or inhibitions and/or no effects at GSH or GST have been reported, even within a single study, depending on many variables, including time, dose, tissue, species, etc. Most of the oxidative stress biomarkers (e.g., superoxide dismutase, catalase, glutathione peroxidase, and glutathione reductase) provided more consistent responses, but only lipid peroxidation (LPO) seemed to fulfill the criteria needed for biomarkers, i.e., a sufficiently long half-life and systematic response. Indeed, reviewed papers demonstrated that toxic cyanobacteria systematically elevate levels of LPO, which indicates the important role of oxidative damage in cyanobacterial toxicity. In summary, the measurement of biochemical changes under laboratory conditions may provide information on the mode of toxic action. However, comparison of different studies is very difficult, and the practical use of detoxification or oxidative stress biomarkers as diagnostic tools or early warnings of cyanobacterial toxicity is questionable.

Návaznosti

ED0001/01/01, projekt VaV

Název: CETOCOEN

GAP503/12/0553, projekt VaV

Název: Metabolity sinic jako potenciální endokrinní disruptory

Investor: Grantová agentura ČR, Metabolity sinic jako potenciální endokrinní disruptory

MSM0021622412, záměr

Název: Interakce mezi chemickými látkami, prostředím a biologickými systémy a jejich důsledky na globální, regionální a lokální úrovni (INCHEMBIOL) (Akronym: INCHEMBIOL)

Investor: Ministerstvo školství, mládeže a tělovýchovy ČR, Interakce mezi chemickými látkami, prostředím a biologickými systémy a jejich důsledky na globální , regionální a lokální úrovni

Citovat

PASKEROVÁ, Hana, Klára HILSCHEROVÁ a Luděk BLÁHA. Oxidative stress and detoxification biomarker responses in aquatic freshwatervertebrates exposed to microcystins and cyanobacterial biomass. Environmental Science and Pollution Research. HEIDELBERG, GERMANY: SPRINGER HEIDELBERG, 2012, roč. 19, č. 6, s. 2024-2037. ISSN 0944-1344. Dostupné z: https://dx.doi.org/10.1007/s11356-012-0960-7.

@article{1066752,
   author = {Paskerová, Hana and Hilscherová, Klára and Bláha, Luděk},
   article_location = {HEIDELBERG, GERMANY},
   article_number = {6},
   doi = {http://dx.doi.org/10.1007/s11356-012-0960-7},
   keywords = {Biomarkers; Cyanobacteria; Detoxification; Fish; Oxidative stress; Microcystin},
   language = {eng},
   issn = {0944-1344},
   journal = {Environmental Science and Pollution Research},
   title = {Oxidative stress and detoxification biomarker responses in aquatic freshwatervertebrates exposed to microcystins and cyanobacterial biomass.},
   volume = {19},
   year = {2012}
}

TY  - JOUR
ID  - 1066752
AU  - Paskerová, Hana - Hilscherová, Klára - Bláha, Luděk
PY  - 2012
TI  - Oxidative stress and detoxification biomarker responses in aquatic freshwatervertebrates exposed to microcystins and cyanobacterial biomass.
JF  - Environmental Science and Pollution Research
VL  - 19
IS  - 6
SP  - 2024-2037
EP  - 2024-2037
PB  - SPRINGER HEIDELBERG
SN  - 09441344
KW  - Biomarkers
KW  - Cyanobacteria
KW  - Detoxification
KW  - Fish
KW  - Oxidative stress
KW  - Microcystin
N2  - Cyanobacterial blooms represent a serious threat to the aquatic environment. Among other effects, biochemical markers have been studied in aquatic vertebrates after exposures to toxic cyanobacteria. Some parameters such as protein phosphatases may serve as selective markers of exposure to microcystins, but under natural conditions, fish are exposed to complex mixtures, which affect the overall biomarker response. This review aims to provide a critical summary of biomarker responses in aquatic vertebrates (mostly fish) to toxic cyanobacteria with a special focus on detoxification and oxidative stress. Detoxification biomarkers such as glutathione (GSH) and glutathione-S-transferase (GST) showed very high variability with poor general trends. Often, stimulations and/or inhibitions and/or no effects at GSH or GST have been reported, even within a single study, depending on many variables, including time, dose, tissue, species, etc. Most of the oxidative stress biomarkers (e.g., superoxide dismutase, catalase, glutathione peroxidase, and glutathione reductase) provided more consistent responses, but only lipid peroxidation (LPO) seemed to fulfill the criteria needed for biomarkers, i.e., a sufficiently long half-life and systematic response. Indeed, reviewed papers demonstrated that toxic cyanobacteria systematically elevate levels of LPO, which indicates the important role of oxidative damage in cyanobacterial toxicity. In summary, the measurement of biochemical changes under laboratory conditions may provide information on the mode of toxic action. However, comparison of different studies is very difficult, and the practical use of detoxification or oxidative stress biomarkers as diagnostic tools or early warnings of cyanobacterial toxicity is questionable.
ER  -

PASKEROVÁ, Hana, Klára HILSCHEROVÁ a Luděk BLÁHA. Oxidative stress and detoxification biomarker responses in aquatic freshwatervertebrates exposed to microcystins and cyanobacterial biomass. \textit{Environmental Science and Pollution Research}. HEIDELBERG, GERMANY: SPRINGER HEIDELBERG, 2012, roč.~19, č.~6, s.~2024-2037. ISSN~0944-1344. Dostupné z: https://dx.doi.org/10.1007/s11356-012-0960-7.

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