Association of PSA level with thiols content in patients with
prostate carcinoma

a 2012

Association of PSA level with thiols content in patients with prostate carcinoma

MASAŘÍK, Michal, Jiří SOCHOR, Ondřej ZÍTKA, David HYNEK, Soňa KŘÍŽKOVÁ et. al.

Basic information

Original name

Association of PSA level with thiols content in patients with prostate carcinoma

Authors

MASAŘÍK, Michal, Jiří SOCHOR, Ondřej ZÍTKA, David HYNEK, Soňa KŘÍŽKOVÁ, Marie STIBOROVÁ, Tomáš ECKSCHLAGER, Vojtěch ADAM and René KIZEK

Edition

15th International Symposium on Molecular Medicine, 2012

Other information

Language

English

Type of outcome

Konferenční abstrakt

Field of Study

10600 1.6 Biological sciences

Country of publisher

Czech Republic

Confidentiality degree

není předmětem státního či obchodního tajemství

Impact factor

Impact factor: 1.957

Organization unit

Faculty of Medicine

ISSN

UT WoS

000310651600170

Keywords in English

PSA; prostate cancer; glutathione

Změněno: 17/10/2012 11:26, Mgr. Martina Raudenská, Ph.D.

Abstract

V originále

To detect proste carcinoma, prostatic specific antigen (PSA) is mostly used. However, diagnostics of this tumour disease can become more precise using other types of molecules. In this study, we aimed at detennination of reduced (GSH) and oxidized (GSSG) glutathione, and its ratio, and level of metallothionein in blood of patients with prostate carcinoma. The obtained results were correlated with PSA levels determined in blood of patients. Analyses were petformed in 35 patients with prostate cancer at the age of 54 to 79 years with an average of 66 years and in 8 healthy subjects, who formed the control group. The correlation between PSA and GSH/GSSG reached R2=0.378. The value of PSA and metallothionein content was correlated with R2 = 0.589. However, there were observed large differences between the values of the ratio of GSH and GSSG, which were significantly (P<0.0 1) higher in the control group than in the group of patients with prostate cancer. Also, differences in content between metallothionein control group and a group of patients were highly significant (P<0.01).

Citovat

MASAŘÍK, Michal, Jiří SOCHOR, Ondřej ZÍTKA, David HYNEK, Soňa KŘÍŽKOVÁ, Marie STIBOROVÁ, Tomáš ECKSCHLAGER, Vojtěch ADAM and René KIZEK. Association of PSA level with thiols content in patients with prostate carcinoma. In 15th International Symposium on Molecular Medicine. 2012. ISSN 1107-3756.

@proceedings{1069037,
   author = {Masařík, Michal and Sochor, Jiří and Zítka, Ondřej and Hynek, David and Křížková, Soňa and Stiborová, Marie and Eckschlager, Tomáš and Adam, Vojtěch and Kizek, René},
   booktitle = {15th International Symposium on Molecular Medicine},
   keywords = {PSA; prostate cancer; glutathione},
   language = {eng},
   title = {Association of PSA level with thiols content in patients with prostate carcinoma},
   year = {2012}
}

TY  - CONF
ID  - 1069037
AU  - Masařík, Michal - Sochor, Jiří - Zítka, Ondřej - Hynek, David - Křížková, Soňa - Stiborová, Marie - Eckschlager, Tomáš - Adam, Vojtěch - Kizek, René
PY  - 2012
TI  - Association of PSA level with thiols content in patients with prostate carcinoma
KW  - PSA
KW  - prostate cancer
KW  - glutathione
N2  - To detect proste carcinoma, prostatic specific antigen (PSA) is mostly used. However, diagnostics of this tumour disease can become more precise using other types of molecules. In this study, we aimed at detennination of reduced (GSH) and oxidized (GSSG) glutathione, and its ratio, and level of metallothionein in blood of patients with prostate carcinoma. The obtained results were correlated with PSA levels determined in blood of patients. Analyses were petformed in 35 patients with prostate cancer at the age of 54 to 79 years with an average of 66 years and in 8 healthy subjects, who formed the control group. The correlation between PSA and GSH/GSSG reached R2=0.378. The value of PSA and metallothionein content was correlated with R2 = 0.589. However, there were observed large differences between the values of the ratio of GSH and GSSG, which were significantly (P<0.0 1) higher in the control group than in the group of patients with prostate cancer. Also, differences in content between metallothionein control group and a group of patients were highly significant (P<0.01).
ER  -

MASAŘÍK, Michal, Jiří SOCHOR, Ondřej ZÍTKA, David HYNEK, Soňa KŘÍŽKOVÁ, Marie STIBOROVÁ, Tomáš ECKSCHLAGER, Vojtěch ADAM and René KIZEK. Association of PSA level with thiols content in patients with prostate carcinoma. In \textit{15th International Symposium on Molecular Medicine}. 2012. ISSN~1107-3756.

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