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@article{1069220,
author = {Kubiczková, Lenka and Sedlaříková, Lenka and Hájek, Roman and Ševčíková, Sabina},
article_location = {London, United Kingdom},
article_number = {"art. 183"},
doi = {http://dx.doi.org/10.1186/1479-5876-10-183},
keywords = {TGF-beta; SMAD proteins; Oncogene; Suppressor; Solid tumors; Leukemia; Multiple myeloma},
language = {eng},
issn = {1479-5876},
journal = {Journal of Translational Medicine},
note = {Open Access Journal of Translational Medicine 2012, 10:183},
title = {TGF-beta - an excellent servant but a bad master},
url = {http://www.translational-medicine.com/content/10/1/183},
volume = {10},
year = {2012}
}
TY - JOUR
ID - 1069220
AU - Kubiczková, Lenka - Sedlaříková, Lenka - Hájek, Roman - Ševčíková, Sabina
PY - 2012
TI - TGF-beta - an excellent servant but a bad master
JF - Journal of Translational Medicine
VL - 10
IS - "art. 183"
SP - "nestrankovano"
EP - "nestrankovano"
PB - BioMed Central
SN - 14795876
N1 - Open Access Journal of Translational Medicine 2012, 10:183
KW - TGF-beta
KW - SMAD proteins
KW - Oncogene
KW - Suppressor
KW - Solid tumors
KW - Leukemia
KW - Multiple myeloma
UR - http://www.translational-medicine.com/content/10/1/183
L2 - http://www.translational-medicine.com/content/10/1/183
N2 - The transforming growth factor (TGF-beta) family of growth factors controls an immense number of cellular responses and figures prominently in development and homeostasis of most human tissues. Work over the past decades has revealed significant insight into the TGF-beta signal transduction network, such as activation of serine/threonine receptors through ligand binding, activation of SMAD proteins through phosphorylation, regulation of target genes expression in association with DNA-binding partners and regulation of SMAD activity and degradation. Disruption of the TGF-beta pathway has been implicated in many human diseases, including solid and hematopoietic tumors. As a potent inhibitor of cell proliferation, TGF-beta acts as a tumor suppressor; however in tumor cells, TGF-beta looses anti-proliferative response and become an oncogenic factor. This article reviews current understanding of TGF-beta signaling and different mechanisms that lead to its impairment in various solid tumors and hematological malignancies.
ER -
KUBICZKOVÁ, Lenka, Lenka SEDLAŘÍKOVÁ, Roman HÁJEK a Sabina ŠEVČÍKOVÁ. TGF-beta - an excellent servant but a bad master. \textit{Journal of Translational Medicine}. London, United Kingdom: BioMed Central, 2012, roč.~10, ''art. 183'', s.~''nestrankovano'', 24 s. ISSN~1479-5876. Dostupné z: https://dx.doi.org/10.1186/1479-5876-10-183.
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