Potential biomarkers for early detection of acute
graft-versus-host disease

J 2012

Potential biomarkers for early detection of acute graft-versus-host disease

LOCHMANOVÁ, Gabriela; Lenka JEDLIČKOVÁ; David POTĚŠIL; Alexandra TOMANCOVÁ; Jan VERNER et al.

Základní údaje

Originální název

Potential biomarkers for early detection of acute graft-versus-host disease

Autoři

LOCHMANOVÁ, Gabriela; Lenka JEDLIČKOVÁ; David POTĚŠIL; Alexandra TOMANCOVÁ; Jan VERNER ; Šárka POSPÍŠILOVÁ; Michael DOUBEK; Jiří MAYER a Zbyněk ZDRÁHAL

Vydání

Proteomics : clinical applications. Weinheim, WILEY-VCH Verlag, 2012, 1862-8346

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30200 3.2 Clinical medicine

Stát vydavatele

Spojené státy

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Impakt faktor

Impact factor: 2.925

Označené pro přenos do RIV

Ano

Kód RIV

RIV/00216224:14740/12:00064911

Organizační jednotka

Středoevropský technologický institut

DOI

https://doi.org/10.1002/prca.201100104

UT WoS

000308093000005

Klíčová slova anglicky

BONE-MARROW-TRANSPLANTATION; STEM-CELL TRANSPLANTATION; C-REACTIVE PROTEIN; SERUM CYTOKINE LEVELS; NECROSIS-FACTOR-ALPHA; ACUTE GVHD; SOLUBLE INTERLEUKIN-2-RECEPTOR; QUANTITATIVE PROTEOMICS; MAJOR COMPLICATIONS; PLASMA BIOMARKERS

Štítky

ok, podil, rivok

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 12. 4. 2013 04:05, Olga Křížová

Anotace

V originále

Acute graft-versus-host disease (aGVHD) is the main complication of allogeneic hematopoietic stem cell transplantation (HCT), resulting in considerable morbidity and mortality. Currently, the diagnosis of aGVHD is largely made based on clinical parameters and invasive biopsies. For the past 20 years, researchers have been trying to find reliable biomarkers to enable early and accurate diagnosis of aGVHD. Although a number of potential aGVHD biomarkers have been published, as yet, no validated diagnostic test is available. Proteomics encompasses a broad range of rapidly developing technologies, which have shown tremendous promise for early detection of aGVHD. In this article, we review the current state of aGVHD biomarker discovery, provide a summary of the key proteins of interest and the most common analytical procedures for the clinic, as well as outlining the significant challenges faced in their use.

Návaznosti

NS9683, projekt VaV

Název: Změny genomu a proteomu u leukemických pacientů s reakcí štěpu proti hostiteli (GvHD)

Investor: Ministerstvo zdravotnictví ČR, Změny genomu a proteomu u leukemických pacientů s reakcí štěpu proti hostiteli (GvHD)

Přiložené soubory

ZVV_2012_10_1074157.pdf

Požádat o autorskou verzi souboru

Citovat

LOCHMANOVÁ, Gabriela; Lenka JEDLIČKOVÁ; David POTĚŠIL; Alexandra TOMANCOVÁ; Jan VERNER; Šárka POSPÍŠILOVÁ; Michael DOUBEK; Jiří MAYER a Zbyněk ZDRÁHAL. Potential biomarkers for early detection of acute graft-versus-host disease. Proteomics : clinical applications. Weinheim: WILEY-VCH Verlag, 2012, roč. 6, 7-8, s. 351-363. ISSN 1862-8346. Dostupné z: https://doi.org/10.1002/prca.201100104.

@article{1074157,
   author = {Lochmanová, Gabriela and Jedličková, Lenka and Potěšil, David and Tomancová, Alexandra and Verner, Jan and Pospíšilová, Šárka and Doubek, Michael and Mayer, Jiří and Zdráhal, Zbyněk},
   article_location = {Weinheim},
   article_number = {7-8},
   doi = {https://doi.org/10.1002/prca.201100104},
   keywords = {BONE-MARROW-TRANSPLANTATION; STEM-CELL TRANSPLANTATION; C-REACTIVE PROTEIN; SERUM CYTOKINE LEVELS; NECROSIS-FACTOR-ALPHA; ACUTE GVHD; SOLUBLE INTERLEUKIN-2-RECEPTOR; QUANTITATIVE PROTEOMICS; MAJOR COMPLICATIONS; PLASMA BIOMARKERS},
   language = {eng},
   issn = {1862-8346},
   journal = {Proteomics : clinical applications.},
   title = {Potential biomarkers for early detection of acute graft-versus-host disease},
   url = {http://www.ncbi.nlm.nih.gov/pubmed/22927351},
   volume = {6},
   year = {2012}
}

TY  - JOUR
ID  - 1074157
AU  - Lochmanová, Gabriela - Jedličková, Lenka - Potěšil, David - Tomancová, Alexandra - Verner, Jan - Pospíšilová, Šárka - Doubek, Michael - Mayer, Jiří - Zdráhal, Zbyněk
PY  - 2012
TI  - Potential biomarkers for early detection of acute graft-versus-host disease
JF  - Proteomics : clinical applications.
VL  - 6
IS  - 7-8
SP  - 351-363
EP  - 351-363
PB  - WILEY-VCH Verlag
SN  - 18628346
KW  - BONE-MARROW-TRANSPLANTATION
KW  - STEM-CELL TRANSPLANTATION
KW  - C-REACTIVE PROTEIN
KW  - SERUM CYTOKINE LEVELS
KW  - NECROSIS-FACTOR-ALPHA
KW  - ACUTE GVHD
KW  - SOLUBLE INTERLEUKIN-2-RECEPTOR
KW  - QUANTITATIVE PROTEOMICS
KW  - MAJOR COMPLICATIONS
KW  - PLASMA BIOMARKERS
UR  - http://www.ncbi.nlm.nih.gov/pubmed/22927351
L2  - http://www.ncbi.nlm.nih.gov/pubmed/22927351
N2  - Acute graft-versus-host disease (aGVHD) is the main complication of allogeneic hematopoietic stem cell transplantation (HCT), resulting in considerable morbidity and mortality. Currently, the diagnosis of aGVHD is largely made based on clinical parameters and invasive biopsies. For the past 20 years, researchers have been trying to find reliable biomarkers to enable early and accurate diagnosis of aGVHD. Although a number of potential aGVHD biomarkers have been published, as yet, no validated diagnostic test is available. Proteomics encompasses a broad range of rapidly developing technologies, which have shown tremendous promise for early detection of aGVHD. In this article, we review the current state of aGVHD biomarker discovery, provide a summary of the key proteins of interest and the most common analytical procedures for the clinic, as well as outlining the significant challenges faced in their use.
ER  -

LOCHMANOVÁ, Gabriela; Lenka JEDLIČKOVÁ; David POTĚŠIL; Alexandra TOMANCOVÁ; Jan VERNER; Šárka POSPÍŠILOVÁ; Michael DOUBEK; Jiří MAYER a Zbyněk ZDRÁHAL. Potential biomarkers for early detection of acute graft-versus-host disease. \textit{Proteomics : clinical applications.}. Weinheim: WILEY-VCH Verlag, 2012, roč.~6, 7-8, s.~351-363. ISSN~1862-8346. Dostupné z: https://doi.org/10.1002/prca.201100104.

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