| BELOHLAVEK, Jan, Karel KUCERA, Jiří JARKOVSKÝ, Ondřej FRANEK, Milana POKORNA, Jiří DANDA, Roman SKRIPSKY, Vít KANDRNAL, Martin BALIK, Jan KUNSTYR, Jan HORAK, Ondrej SMID, Jaroslav VALASEK, Vratislav MRAZEK, Zdenek SCHWARZ a Ales LINHART. Hyperinvasive approach to out-of hospital cardiac arrest using mechanical chest compression device, prehospital intraarrest cooling, extracorporeal life support and early invasive assessment compared to standard of care. A randomized parallel groups ... Journal of Translational Medicine. 2012, roč. 10, "art. 163", s. "nestrankovano", 13 s. ISSN 1479-5876. Dostupné z: https://dx.doi.org/10.1186/1479-5876-10-163. |
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@article{1074296,
author = {Belohlavek, Jan and Kucera, Karel and Jarkovský, Jiří and Franek, Ondřej and Pokorna, Milana and Danda, Jiří and Skripsky, Roman and Kandrnal, Vít and Balik, Martin and Kunstyr, Jan and Horak, Jan and Smid, Ondrej and Valasek, Jaroslav and Mrazek, Vratislav and Schwarz, Zdenek and Linhart, Ales},
article_number = {"art. 163"},
doi = {http://dx.doi.org/10.1186/1479-5876-10-163},
keywords = {Cardiac arrest; Hypothermia; Extracorporeal life support; Mechanical compression device; Invasive assessment},
language = {eng},
issn = {1479-5876},
journal = {Journal of Translational Medicine},
title = {Hyperinvasive approach to out-of hospital cardiac arrest using mechanical chest compression device, prehospital intraarrest cooling, extracorporeal life support and early invasive assessment compared to standard of care. A randomized parallel groups ...},
url = {http://www.translational-medicine.com/content/10/1/163},
volume = {10},
year = {2012}
}
TY - JOUR
ID - 1074296
AU - Belohlavek, Jan - Kucera, Karel - Jarkovský, Jiří - Franek, Ondřej - Pokorna, Milana - Danda, Jiří - Skripsky, Roman - Kandrnal, Vít - Balik, Martin - Kunstyr, Jan - Horak, Jan - Smid, Ondrej - Valasek, Jaroslav - Mrazek, Vratislav - Schwarz, Zdenek - Linhart, Ales
PY - 2012
TI - Hyperinvasive approach to out-of hospital cardiac arrest using mechanical chest compression device, prehospital intraarrest cooling, extracorporeal life support and early invasive assessment compared to standard of care. A randomized parallel groups ...
JF - Journal of Translational Medicine
VL - 10
IS - "art. 163"
SP - "nestrankovano"
EP - "nestrankovano"
SN - 14795876
KW - Cardiac arrest
KW - Hypothermia
KW - Extracorporeal life support
KW - Mechanical compression device
KW - Invasive assessment
UR - http://www.translational-medicine.com/content/10/1/163
L2 - http://www.translational-medicine.com/content/10/1/163
N2 - Out of hospital cardiac arrest (OHCA) has a poor outcome. Recent non-randomized studies of ECLS (extracorporeal life support) in OHCA suggested further prospective multicenter studies to define population that would benefit from ECLS. We aim to perform a prospective randomized study comparing prehospital intraarrest hypothermia combined with mechanical chest compression device, intrahospital ECLS and early invasive investigation and treatment in all patients with OHCA of presumed cardiac origin compared to a standard of care. Methods This paper describes methodology and design of the proposed trial. Patients with witnessed OHCA without ROSC (return of spontaneous circulation) after a minimum of 5 minutes of ACLS (advanced cardiac life support) by emergency medical service (EMS) team and after performance of all initial procedures (defibrillation, airway management, intravenous access establishment) will be randomized to standard vs. hyperinvasive arm. In hyperinvasive arm, mechanical compression device together with intranasal evaporative cooling will be instituted and patients will be transferred directly to cardiac center under ongoing CPR (cardiopulmonary resuscitation). After admission, ECLS inclusion/exclusion criteria will be evaluated and if achieved, veno-arterial ECLS will be started. Invasive investigation and standard post resuscitation care will follow. Patients in standard arm will be managed on scene. When ROSC achieved, they will be transferred to cardiac center and further treated as per recent guidelines. Primary outcome 6 months survival with good neurological outcome (Cerebral Performance Category 1–2). Secondary outcomes will include 30 day neurological and cardiac recovery. Discussion Authors introduce and offer a protocol of a proposed randomized study comparing a combined “hyper invasive approach” to a standard of care in refractory OHCA. The protocol is opened for sharing by other cardiac centers with available ECLS and cathlab teams trained to admit patients with refractory cardiac arrest under ongoing CPR. A prove of concept study will be started soon. The aim of the authors is to establish a net of centers for a multicenter trial initiation in future.
ER -
BELOHLAVEK, Jan, Karel KUCERA, Jiří JARKOVSKÝ, Ondřej FRANEK, Milana POKORNA, Jiří DANDA, Roman SKRIPSKY, Vít KANDRNAL, Martin BALIK, Jan KUNSTYR, Jan HORAK, Ondrej SMID, Jaroslav VALASEK, Vratislav MRAZEK, Zdenek SCHWARZ a Ales LINHART. Hyperinvasive approach to out-of hospital cardiac arrest using mechanical chest compression device, prehospital intraarrest cooling, extracorporeal life support and early invasive assessment compared to standard of care. A randomized parallel groups ... \textit{Journal of Translational Medicine}. 2012, roč.~10, ''art. 163'', s.~''nestrankovano'', 13 s. ISSN~1479-5876. Dostupné z: https://dx.doi.org/10.1186/1479-5876-10-163.
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