Genetic diversity in Treponema pallidum: Implications for
pathogenesis, evolution and molecular diagnostics of syphilis
and yaws

J 2012

Genetic diversity in Treponema pallidum: Implications for pathogenesis, evolution and molecular diagnostics of syphilis and yaws

ŠMAJS, David, Steven J. NORRIS a George M. WEINSTOCK

Základní údaje

Originální název

Genetic diversity in Treponema pallidum: Implications for pathogenesis, evolution and molecular diagnostics of syphilis and yaws

Autoři

ŠMAJS, David (203 Česká republika, garant, domácí), Steven J. NORRIS (840 Spojené státy) a George M. WEINSTOCK (840 Spojené státy)

Vydání

Infection, Genetics and Evolution, AMSTERDAM, ELSEVIER SCIENCE BV, 2012, 1567-1348

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

10600 1.6 Biological sciences

Stát vydavatele

Nizozemské království

Utajení

není předmětem státního či obchodního tajemství

Impakt faktor

Impact factor: 2.768

Kód RIV

RIV/00216224:14110/12:00057855

Organizační jednotka

Lékařská fakulta

DOI

http://dx.doi.org/10.1016/j.meegid.2011.12.001

UT WoS

000302512100002

Klíčová slova anglicky

Treponema pallidum; Treponema pallidum ssp pertenue; Treponema pallidum ssp endemicum; Treponema paraluiscuniculi; Whole genome sequencing; Molecular evolution; Molecular diagnostics

Příznaky

Mezinárodní význam

Změněno: 28. 11. 2012 11:36, Mgr. Michal Petr

Anotace

V originále

Pathogenic uncultivable treponemes, similar to syphilis-causing Treponema pallidum subspecies pallidum, include T. pallidum ssp. pertenue, T. pallidum ssp. endemicum and Treponema carateum, which cause yaws, bejel and pinta, respectively. Genetic analyses of these pathogens revealed striking similarity among these bacteria and also a high degree of similarity to the rabbit pathogen, Treponema paraluiscuniculi, a treponeme not infectious to humans. Genome comparisons between pallidum and non-pallidum treponemes revealed genes with potential involvement in human infectivity, whereas comparisons between pallidum and pertenue treponemes identified genes possibly involved in the high invasivity of syphilis treponemes. Genetic variability within syphilis strains is considered as the basis of syphilis molecular epidemiology with potential to detect more virulent strains, whereas genetic variability within a single strain is related to its ability to elude the immune system of the host. Genome analyses also shed light on treponemal evolution and on chromosomal targets for molecular diagnostics of treponemal infections. (C) 2011 Elsevier B.V. All rights reserved.

Návaznosti

GA310/04/0021, projekt VaV

Název: Postgenomické studie syfilitické spirochety Treponema pallidum

Investor: Grantová agentura ČR, Postgenomické studie syfilitické spirochety Treponema pallidum

MSM0021622415, záměr

Název: Molekulární podstata buněčných a tkáňových regulací

Investor: Ministerstvo školství, mládeže a tělovýchovy ČR, Molekulární podstata buněčných a tkáňových regulací

NT11159, projekt VaV

Název: Mapování výskytu makrolidové rezistence původce syfilis v ČR a molekulární typizace jednotlivých syfilitických kmenů

Investor: Ministerstvo zdravotnictví ČR, Mapování výskytu makrolidové rezistence původce syfilis v ČR a molekulární typizace jednotlivých syfilitických kmenů

Přiložené soubory

1-s2.0-S156713481100445X-main.pdf

Požádat o autorskou verzi souboru

Citovat

ŠMAJS, David, Steven J. NORRIS a George M. WEINSTOCK. Genetic diversity in Treponema pallidum: Implications for pathogenesis, evolution and molecular diagnostics of syphilis and yaws. Infection, Genetics and Evolution. AMSTERDAM: ELSEVIER SCIENCE BV, 2012, roč. 12, č. 2, s. 191-202. ISSN 1567-1348. Dostupné z: https://dx.doi.org/10.1016/j.meegid.2011.12.001.

@article{1075187,
   author = {Šmajs, David and Norris, Steven J. and Weinstock, George M.},
   article_location = {AMSTERDAM},
   article_number = {2},
   doi = {http://dx.doi.org/10.1016/j.meegid.2011.12.001},
   keywords = {Treponema pallidum; Treponema pallidum ssp pertenue; Treponema pallidum ssp endemicum; Treponema paraluiscuniculi; Whole genome sequencing; Molecular evolution; Molecular diagnostics},
   language = {eng},
   issn = {1567-1348},
   journal = {Infection, Genetics and Evolution},
   title = {Genetic diversity in Treponema pallidum: Implications for pathogenesis, evolution and molecular diagnostics of syphilis and yaws},
   volume = {12},
   year = {2012}
}

TY  - JOUR
ID  - 1075187
AU  - Šmajs, David - Norris, Steven J. - Weinstock, George M.
PY  - 2012
TI  - Genetic diversity in Treponema pallidum: Implications for pathogenesis, evolution and molecular diagnostics of syphilis and yaws
JF  - Infection, Genetics and Evolution
VL  - 12
IS  - 2
SP  - 191-202
EP  - 191-202
PB  - ELSEVIER SCIENCE BV
SN  - 15671348
KW  - Treponema pallidum
KW  - Treponema pallidum ssp pertenue
KW  - Treponema pallidum ssp endemicum
KW  - Treponema paraluiscuniculi
KW  - Whole genome sequencing
KW  - Molecular evolution
KW  - Molecular diagnostics
N2  - Pathogenic uncultivable treponemes, similar to syphilis-causing Treponema pallidum subspecies pallidum, include T. pallidum ssp. pertenue, T. pallidum ssp. endemicum and Treponema carateum, which cause yaws, bejel and pinta, respectively. Genetic analyses of these pathogens revealed striking similarity among these bacteria and also a high degree of similarity to the rabbit pathogen, Treponema paraluiscuniculi, a treponeme not infectious to humans. Genome comparisons between pallidum and non-pallidum treponemes revealed genes with potential involvement in human infectivity, whereas comparisons between pallidum and pertenue treponemes identified genes possibly involved in the high invasivity of syphilis treponemes. Genetic variability within syphilis strains is considered as the basis of syphilis molecular epidemiology with potential to detect more virulent strains, whereas genetic variability within a single strain is related to its ability to elude the immune system of the host. Genome analyses also shed light on treponemal evolution and on chromosomal targets for molecular diagnostics of treponemal infections. (C) 2011 Elsevier B.V. All rights reserved.
ER  -

ŠMAJS, David, Steven J. NORRIS a George M. WEINSTOCK. Genetic diversity in Treponema pallidum: Implications for pathogenesis, evolution and molecular diagnostics of syphilis and yaws. \textit{Infection, Genetics and Evolution}. AMSTERDAM: ELSEVIER SCIENCE BV, 2012, roč.~12, č.~2, s.~191-202. ISSN~1567-1348. Dostupné z: https://dx.doi.org/10.1016/j.meegid.2011.12.001.

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