Kinetic Study of Metal Complexes with Tetraazamacrocyclic Ligands with Carboxylate/Phosphonate Pendant Arms

LUBAL, Přemysl, Petr HERMANN, Jan KOTEK, M.P.C. CAMPELLO and I. SANTOS. Kinetic Study of Metal Complexes with Tetraazamacrocyclic Ligands with Carboxylate/Phosphonate Pendant Arms. In ISMEC ACTA. 2012. ISSN 2239-2459.

Basic information

• Original name: Kinetic Study of Metal Complexes with Tetraazamacrocyclic Ligands with Carboxylate/Phosphonate Pendant Arms
• Authors: LUBAL, Přemysl (203 Czech Republic, guarantor, belonging to the institution), Petr HERMANN (203 Czech Republic), Jan KOTEK (203 Czech Republic), M.P.C. CAMPELLO (620 Portugal) and I. SANTOS (620 Portugal).
• Edition: ISMEC ACTA, 2012.

Other information

• Original language: English
• Type of outcome: Conference abstract
• Field of Study: 10406 Analytical chemistry
• Country of publisher: Portugal
• Confidentiality degree: is not subject to a state or trade secret
• RIV identification code: RIV/00216224:14740/12:00062140
• Organization unit: Central European Institute of Technology
• ISSN: 2239-2459
• Keywords (in Czech): macrocyklické ligandy; kovové komplexy; kinetics
• Keywords in English: macrocyclic ligands; metal complexes; kinetics

Abstract

Ln(III) and Cu(II) complexes are utilized in medicine and preclinical research as magnetic resonance, optical or nuclear probes for diagnostics and/or for cancer treatment. For biomedical applications, such complexes should exhibit a high thermodynamic stability as well as kinetic inertness under physiological conditions. Thus, knowledge of their thermodynamic/kinetic properties (e.g. dissociation rate constants for an estimation of kinetic inertness) is important to evaluate their use in these applications. Here, thermodynamic and kinetic properties of Cu(II), Ce(III) and Eu(III) complexes with macrocyclic cyclen-based ligands where acetate pendant arms were substituted by phosphonates (H4dota, H5do3ap, trans-H6do2a2p, H7doa3p, H8dotp) [1–4] are presented. In addition, the influence of substitution of one acetate/phosphonate of (H2do2a/H3do3a/H4dota/H5do3ap derivatives) and/or all phosphonate pendant arms (H8dotp derivatives) was also studied [5-7]. These results show that the kinetic inertness of the metal complexes is influenced by these substitutions and, therefore, this fact should be taken into account in possible in vivo applications of the ligands/complexes.

Links

• ED1.1.00/02.0068, research and development project: Name: CEITEC - central european institute of technology
• ME09065, research and development project: Name: Výzkum nových detekčních systémů na bázi senzorových polí pro použití ve speciační analýze

Investor: Ministry of Education, Youth and Sports of the CR, Research of new detection systems based on sensor arrays for application in speciation analysis, Research and Development Programme KONTAKT (ME)