MicroRNAs are promising biomarkers and therapeutic targets in
high-grade gliomas

a 2012

MicroRNAs are promising biomarkers and therapeutic targets in high-grade gliomas

ŠÁNA, Jiří, Radek LAKOMÝ, Andrej BEŠŠE, Simona HANKEOVÁ, Leoš KŘEN et. al.

Základní údaje

Originální název

MicroRNAs are promising biomarkers and therapeutic targets in high-grade gliomas

Autoři

ŠÁNA, Jiří (203 Česká republika, domácí), Radek LAKOMÝ (203 Česká republika), Andrej BEŠŠE (703 Slovensko, domácí), Simona HANKEOVÁ (203 Česká republika), Leoš KŘEN (203 Česká republika), Martin SMRČKA (203 Česká republika), Rostislav VYZULA (203 Česká republika) a Ondřej SLABÝ (203 Česká republika, garant, domácí)

Vydání

3rd ICCTI Workshop - MicroRNAs in Oncology, 2012

Další údaje

Jazyk

angličtina

Typ výsledku

Konferenční abstrakt

Obor

30200 3.2 Clinical medicine

Stát vydavatele

Česká republika

Utajení

není předmětem státního či obchodního tajemství

Kód RIV

RIV/00216224:14740/12:00062179

Organizační jednotka

Středoevropský technologický institut

Klíčová slova anglicky

microRNAs; biomarkers; oncology; therapeutic targets; high-grade gliomas

Změněno: 5. 12. 2012 10:22, Mgr. Petra Vychytilová, Ph.D.

Anotace

V originále

High-grade gliomas are highly malignant primary brain tumors of supportive glial cells origin. Despite optimal course of treatment, including maximal surgical resection followed by chemo- and/orradiotherapy, the prognosis still remains poor. The main reason is the commonly occurring chemo-radioresistance that is manifested by early progression after or even during oncology treatment. Accurate prediction of therapy response and adjuvant therapeutic approach enabling an overcoming of resistance consist the main aims of glioma translationalresearch. The important role in therapeutic resistance play cancer stem cells (CSCs) and thus, signaling pathways related to maintaining stem-like phenotype. Glioma stem cells (GSCs) are associated with time to progression and overall survival of glioma patients. In recent years, it was shown that biological features of GSCs could be effectively regulated by microRNAs (miRNAs), short endogenou RNA molecules that post-transcriptionally regulate gene expression. MiRNAs have been described to be deregulated in gliomas and associated with therapy response and survival of glioma patients. Introduction to miRNAs involvement to GSCs biology, and our recent data from this field will be presented.

Návaznosti

ED1.1.00/02.0068, projekt VaV

Název: CEITEC - central european institute of technology

NT13514, projekt VaV

Název: Analýza mikroRNA v glioblastomových kmenových buňkách: predikce léčebné odpovědi a identifikace nových terapeutických cílů u pacientů s glioblastomem

Citovat

ŠÁNA, Jiří, Radek LAKOMÝ, Andrej BEŠŠE, Simona HANKEOVÁ, Leoš KŘEN, Martin SMRČKA, Rostislav VYZULA a Ondřej SLABÝ. MicroRNAs are promising biomarkers and therapeutic targets in high-grade gliomas. In 3rd ICCTI Workshop - MicroRNAs in Oncology. 2012.

@proceedings{1076191,
   author = {Šána, Jiří and Lakomý, Radek and Bešše, Andrej and Hankeová, Simona and Křen, Leoš and Smrčka, Martin and Vyzula, Rostislav and Slabý, Ondřej},
   booktitle = {3rd ICCTI Workshop - MicroRNAs in Oncology},
   keywords = {microRNAs; biomarkers; oncology; therapeutic targets; high-grade gliomas},
   language = {eng},
   title = {MicroRNAs are promising biomarkers and therapeutic targets in high-grade gliomas},
   year = {2012}
}

TY  - CONF
ID  - 1076191
AU  - Šána, Jiří - Lakomý, Radek - Bešše, Andrej - Hankeová, Simona - Křen, Leoš - Smrčka, Martin - Vyzula, Rostislav - Slabý, Ondřej
PY  - 2012
TI  - MicroRNAs are promising biomarkers and therapeutic targets in high-grade gliomas
KW  - microRNAs
KW  - biomarkers
KW  - oncology
KW  - therapeutic targets
KW  - high-grade gliomas
N2  - High-grade gliomas are highly malignant primary brain tumors of supportive glial cells origin. Despite optimal course of treatment, including maximal surgical resection followed by chemo- and/orradiotherapy, the prognosis still remains poor. The main reason is the commonly occurring chemo-radioresistance that is manifested by early progression after or even during oncology treatment. Accurate prediction of therapy response and adjuvant therapeutic approach enabling an overcoming of resistance consist the main aims of glioma translationalresearch. The important role in therapeutic resistance play cancer stem cells (CSCs) and thus, signaling pathways related to maintaining stem-like phenotype. Glioma stem cells (GSCs) are associated with time to progression and overall survival of glioma patients. In recent years, it was shown that biological features of GSCs could be effectively regulated by microRNAs (miRNAs), short endogenou RNA molecules that post-transcriptionally regulate gene expression. MiRNAs have been described to be deregulated in gliomas and associated with therapy response and survival of glioma patients. Introduction to miRNAs involvement to GSCs biology, and our recent data from this field will be presented.
ER  -

ŠÁNA, Jiří, Radek LAKOMÝ, Andrej BEŠŠE, Simona HANKEOVÁ, Leoš KŘEN, Martin SMRČKA, Rostislav VYZULA a Ondřej SLABÝ. MicroRNAs are promising biomarkers and therapeutic targets in high-grade gliomas. In \textit{3rd ICCTI Workshop - MicroRNAs in Oncology}. 2012.

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