MicroRNAs are promising biomarkers and therapeutic targets in high-grade gliomas

ŠÁNA, Jiří, Radek LAKOMÝ, Andrej BEŠŠE, Simona HANKEOVÁ, Leoš KŘEN, Martin SMRČKA, Rostislav VYZULA and Ondřej SLABÝ. MicroRNAs are promising biomarkers and therapeutic targets in high-grade gliomas. In 3rd ICCTI Workshop - MicroRNAs in Oncology. 2012.

Basic information

• Original name: MicroRNAs are promising biomarkers and therapeutic targets in high-grade gliomas
• Authors: ŠÁNA, Jiří (203 Czech Republic, belonging to the institution), Radek LAKOMÝ (203 Czech Republic), Andrej BEŠŠE (703 Slovakia, belonging to the institution), Simona HANKEOVÁ (203 Czech Republic), Leoš KŘEN (203 Czech Republic), Martin SMRČKA (203 Czech Republic), Rostislav VYZULA (203 Czech Republic) and Ondřej SLABÝ (203 Czech Republic, guarantor, belonging to the institution).
• Edition: 3rd ICCTI Workshop - MicroRNAs in Oncology, 2012.

Other information

• Original language: English
• Type of outcome: Conference abstract
• Field of Study: 30200 3.2 Clinical medicine
• Country of publisher: Czech Republic
• Confidentiality degree: is not subject to a state or trade secret
• RIV identification code: RIV/00216224:14740/12:00062179
• Organization unit: Central European Institute of Technology
• Keywords in English: microRNAs; biomarkers; oncology; therapeutic targets; high-grade gliomas

Abstract

High-grade gliomas are highly malignant primary brain tumors of supportive glial cells origin. Despite optimal course of treatment, including maximal surgical resection followed by chemo- and/orradiotherapy, the prognosis still remains poor. The main reason is the commonly occurring chemo-radioresistance that is manifested by early progression after or even during oncology treatment. Accurate prediction of therapy response and adjuvant therapeutic approach enabling an overcoming of resistance consist the main aims of glioma translationalresearch. The important role in therapeutic resistance play cancer stem cells (CSCs) and thus, signaling pathways related to maintaining stem-like phenotype. Glioma stem cells (GSCs) are associated with time to progression and overall survival of glioma patients. In recent years, it was shown that biological features of GSCs could be effectively regulated by microRNAs (miRNAs), short endogenou RNA molecules that post-transcriptionally regulate gene expression. MiRNAs have been described to be deregulated in gliomas and associated with therapy response and survival of glioma patients. Introduction to miRNAs involvement to GSCs biology, and our recent data from this field will be presented.

Links

• ED1.1.00/02.0068, research and development project: Name: CEITEC - central european institute of technology
• NT13514, research and development project: Name: Analýza mikroRNA v glioblastomových kmenových buňkách: predikce léčebné odpovědi a identifikace nových terapeutických cílů u pacientů s glioblastomem