| KREJČÍ, Lumír, Veronika ALTMANNOVÁ, Mário ŠPÍREK and Xiaolan ZHAO. Homologous recombination and its regulation. Nucleic Acids Research. Oxford, UK: Oxford Press, 2012, vol. 40, No 13, p. 5795-5818. ISSN 0305-1048. Available from: https://dx.doi.org/10.1093/nar/gks270. |
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@article{1077886,
author = {Krejčí, Lumír and Altmannová, Veronika and Špírek, Mário and Zhao, Xiaolan},
article_location = {Oxford, UK},
article_number = {13},
doi = {http://dx.doi.org/10.1093/nar/gks270},
keywords = {DOUBLE-STRAND-BREAK; REPLICATION PROTEIN-A; DNA-DAMAGE RESPONSE; RAD51 NUCLEOPROTEIN FILAMENTS; SACCHAROMYCES-CEREVISIAE SRS2; CANCER SUSCEPTIBILITY GENE; BLOOMS-SYNDROME HELICASE; JOINT MOLECULE FORMATION; ESCHERICHIA-COLI RECA; HUMAN BRCA2 PROTEIN},
language = {eng},
issn = {0305-1048},
journal = {Nucleic Acids Research},
title = {Homologous recombination and its regulation},
volume = {40},
year = {2012}
}
TY - JOUR
ID - 1077886
AU - Krejčí, Lumír - Altmannová, Veronika - Špírek, Mário - Zhao, Xiaolan
PY - 2012
TI - Homologous recombination and its regulation
JF - Nucleic Acids Research
VL - 40
IS - 13
SP - 5795-5818
EP - 5795-5818
PB - Oxford Press
SN - 03051048
KW - DOUBLE-STRAND-BREAK
KW - REPLICATION PROTEIN-A
KW - DNA-DAMAGE RESPONSE
KW - RAD51 NUCLEOPROTEIN FILAMENTS
KW - SACCHAROMYCES-CEREVISIAE SRS2
KW - CANCER SUSCEPTIBILITY GENE
KW - BLOOMS-SYNDROME HELICASE
KW - JOINT MOLECULE FORMATION
KW - ESCHERICHIA-COLI RECA
KW - HUMAN BRCA2 PROTEIN
N2 - Homologous recombination (HR) is critical both for repairing DNA lesions in mitosis and for chromosomal pairing and exchange during meiosis. However, some forms of HR can also lead to undesirable DNA rearrangements. Multiple regulatory mechanisms have evolved to ensure that HR takes place at the right time, place and manner. Several of these impinge on the control of Rad51 nucleofilaments that play a central role in HR. Some factors promote the formation of these structures while others lead to their disassembly or the use of alternative repair pathways. In this article, we review these mechanisms in both mitotic and meiotic environments and in different eukaryotic taxa, with an emphasis on yeast and mammal systems. Since mutations in several proteins that regulate Rad51 nucleofilaments are associated with cancer and cancer-prone syndromes, we discuss how understanding their functions can lead to the development of better tools for cancer diagnosis and therapy.
ER -
KREJČÍ, Lumír, Veronika ALTMANNOVÁ, Mário ŠPÍREK and Xiaolan ZHAO. Homologous recombination and its regulation. \textit{Nucleic Acids Research}. Oxford, UK: Oxford Press, 2012, vol.~40, No~13, p.~5795-5818. ISSN~0305-1048. Available from: https://dx.doi.org/10.1093/nar/gks270.
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