2013
Development of a novel enzyme-linked immunosorbent assay (ELISA) for measurement of serum CTRP1 A pilot study: Measurement of serum CTRP1 in healthy donors and patients with metabolic syndrome
CHALUPOVÁ, Lenka, Alena ŽÁKOVSKÁ a K. ADAMCOVÁZákladní údaje
Originální název
Development of a novel enzyme-linked immunosorbent assay (ELISA) for measurement of serum CTRP1 A pilot study: Measurement of serum CTRP1 in healthy donors and patients with metabolic syndrome
Autoři
CHALUPOVÁ, Lenka (203 Česká republika, domácí), Alena ŽÁKOVSKÁ (203 Česká republika, garant, domácí) a K. ADAMCOVÁ (203 Česká republika)
Vydání
Clinical Biochemistry, ELSEVIER, 2013, 0009-9120
Další údaje
Jazyk
angličtina
Typ výsledku
Článek v odborném periodiku
Obor
30102 Immunology
Stát vydavatele
Česká republika
Utajení
není předmětem státního či obchodního tajemství
Impakt faktor
Impact factor: 2.229
Kód RIV
RIV/00216224:14310/13:00067579
Organizační jednotka
Přírodovědecká fakulta
UT WoS
000313406800016
Klíčová slova anglicky
ELISA CTRP1 Obesity Hypertension Adipokine Metabolic syndrome
Změněno: 25. 4. 2014 14:15, Ing. Zdeňka Rašková
Anotace
V originále
Background: Complement C1q tumor necrosis factor-related protein 1 (CTRP1), a recently identified adipokine, was found to stimulate aldosterone production. Obesity and metabolic syndrome are frequently associated with elevated levels of aldosterone. Therefore, it would be interesting to investigate whether the secretion of CTRP1 in human serum is associated with obesity as well as with hypertension. Aim: This study evaluated serum CTRP1 concentrations in healthy individuals and patients with metabolic syndrome. Methods: Serum samples from 61 healthy individuals and 46 patients with metabolic syndrome were measured for CTRP1 by enzyme-linked immunosorbent assay (ELISA). Results: Correlation analyses showed that serum CTRP1 in healthy individuals did not correlate with BMI, leptin, TG, HDL-CH, and LDL-CH; however, in patients with metabolic syndrome, CTRP1 correlated with glucose, HbA1c and BMI. CTRP1 level was significantly higher in subjects with metabolic syndrome compared to healthy subjects. Discussion: Our results support the hypothesis that adipokine CTRP1 is associated with metabolic syndrome and obesity compared to healthy individuals.