Development of a novel enzyme-linked immunosorbent assay
(ELISA) for measurement of serum CTRP1 A pilot study:
Measurement of serum CTRP1 in healthy donors and patients with
metabolic syndrome

J 2013

Development of a novel enzyme-linked immunosorbent assay (ELISA) for measurement of serum CTRP1 A pilot study: Measurement of serum CTRP1 in healthy donors and patients with metabolic syndrome

CHALUPOVÁ, Lenka, Alena ŽÁKOVSKÁ a K. ADAMCOVÁ

Základní údaje

Originální název

Development of a novel enzyme-linked immunosorbent assay (ELISA) for measurement of serum CTRP1 A pilot study: Measurement of serum CTRP1 in healthy donors and patients with metabolic syndrome

Autoři

CHALUPOVÁ, Lenka (203 Česká republika, domácí), Alena ŽÁKOVSKÁ (203 Česká republika, garant, domácí) a K. ADAMCOVÁ (203 Česká republika)

Vydání

Clinical Biochemistry, ELSEVIER, 2013, 0009-9120

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30102 Immunology

Stát vydavatele

Česká republika

Utajení

není předmětem státního či obchodního tajemství

Impakt faktor

Impact factor: 2.229

Kód RIV

RIV/00216224:14310/13:00067579

Organizační jednotka

Přírodovědecká fakulta

DOI

http://dx.doi.org/10.1016/j.clinbiochem.2012.09.006

UT WoS

000313406800016

Klíčová slova anglicky

ELISA CTRP1 Obesity Hypertension Adipokine Metabolic syndrome

Štítky

AKR, rivok, ZR

Změněno: 25. 4. 2014 14:15, Ing. Zdeňka Rašková

Anotace

V originále

Background: Complement C1q tumor necrosis factor-related protein 1 (CTRP1), a recently identified adipokine, was found to stimulate aldosterone production. Obesity and metabolic syndrome are frequently associated with elevated levels of aldosterone. Therefore, it would be interesting to investigate whether the secretion of CTRP1 in human serum is associated with obesity as well as with hypertension. Aim: This study evaluated serum CTRP1 concentrations in healthy individuals and patients with metabolic syndrome. Methods: Serum samples from 61 healthy individuals and 46 patients with metabolic syndrome were measured for CTRP1 by enzyme-linked immunosorbent assay (ELISA). Results: Correlation analyses showed that serum CTRP1 in healthy individuals did not correlate with BMI, leptin, TG, HDL-CH, and LDL-CH; however, in patients with metabolic syndrome, CTRP1 correlated with glucose, HbA1c and BMI. CTRP1 level was significantly higher in subjects with metabolic syndrome compared to healthy subjects. Discussion: Our results support the hypothesis that adipokine CTRP1 is associated with metabolic syndrome and obesity compared to healthy individuals.

Citovat

CHALUPOVÁ, Lenka, Alena ŽÁKOVSKÁ a K. ADAMCOVÁ. Development of a novel enzyme-linked immunosorbent assay (ELISA) for measurement of serum CTRP1 A pilot study: Measurement of serum CTRP1 in healthy donors and patients with metabolic syndrome. Clinical Biochemistry. ELSEVIER, 2013, roč. 46, 1-2, s. 73-78. ISSN 0009-9120. Dostupné z: https://dx.doi.org/10.1016/j.clinbiochem.2012.09.006.

@article{1079023,
   author = {Chalupová, Lenka and Žákovská, Alena and Adamcová, K. and Adamcová, Kateřina},
   article_number = {1-2},
   doi = {http://dx.doi.org/10.1016/j.clinbiochem.2012.09.006},
   keywords = {ELISA CTRP1 Obesity Hypertension Adipokine Metabolic syndrome},
   language = {eng},
   issn = {0009-9120},
   journal = {Clinical Biochemistry},
   title = {Development of a novel enzyme-linked immunosorbent assay (ELISA) for measurement of serum CTRP1 A pilot study: Measurement of serum CTRP1 in healthy donors and patients with metabolic syndrome},
   volume = {46},
   year = {2013}
}

TY  - JOUR
ID  - 1079023
AU  - Chalupová, Lenka - Žákovská, Alena - Adamcová, K. - Adamcová, Kateřina
PY  - 2013
TI  - Development of a novel enzyme-linked immunosorbent assay (ELISA) for measurement of serum CTRP1 A pilot study: Measurement of serum CTRP1 in healthy donors and patients with metabolic syndrome
JF  - Clinical Biochemistry
VL  - 46
IS  - 1-2
SP  - 73-78
EP  - 73-78
PB  - ELSEVIER
SN  - 00099120
KW  - ELISA CTRP1 Obesity Hypertension Adipokine Metabolic syndrome
N2  - Background: Complement C1q tumor necrosis factor-related protein 1 (CTRP1), a recently identified adipokine, was found to stimulate aldosterone production. Obesity and metabolic syndrome are frequently associated with elevated levels of aldosterone. Therefore, it would be interesting to investigate whether the secretion of CTRP1 in human serum is associated with obesity as well as with hypertension. Aim: This study evaluated serum CTRP1 concentrations in healthy individuals and patients with metabolic syndrome. Methods: Serum samples from 61 healthy individuals and 46 patients with metabolic syndrome were measured for CTRP1 by enzyme-linked immunosorbent assay (ELISA). Results: Correlation analyses showed that serum CTRP1 in healthy individuals did not correlate with BMI, leptin, TG, HDL-CH, and LDL-CH; however, in patients with metabolic syndrome, CTRP1 correlated with glucose, HbA1c and BMI. CTRP1 level was significantly higher in subjects with metabolic syndrome compared to healthy subjects. Discussion: Our results support the hypothesis that adipokine CTRP1 is associated with metabolic syndrome and obesity compared to healthy individuals.
ER  -

CHALUPOVÁ, Lenka, Alena ŽÁKOVSKÁ a K. ADAMCOVÁ. Development of a novel enzyme-linked immunosorbent assay (ELISA) for measurement of serum CTRP1 A pilot study: Measurement of serum CTRP1 in healthy donors and patients with metabolic syndrome. \textit{Clinical Biochemistry}. ELSEVIER, 2013, roč.~46, 1-2, s.~73-78. ISSN~0009-9120. Dostupné z: https://dx.doi.org/10.1016/j.clinbiochem.2012.09.006.

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