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@article{1079676,
author = {Skender, Belma and Hofmanová, Jiřina and Vaculová Hyršlová, Alena},
article_location = {OLOMOUC},
article_number = {3},
doi = {http://dx.doi.org/10.5507/bp.2012.093},
keywords = {polyunsaturated fatty acids; docosahexaenoic acid; colon cancer; apoptosis; cell signalling; anticancer therapy},
language = {eng},
issn = {1213-8118},
journal = {BIOMEDICAL PAPERS-OLOMOUC},
title = {Docosahexaenoic fatty acid (DHA) in the regulation of colon cell growth and cell death: A review},
volume = {156},
year = {2012}
}
TY - JOUR
ID - 1079676
AU - Skender, Belma - Hofmanová, Jiřina - Vaculová Hyršlová, Alena
PY - 2012
TI - Docosahexaenoic fatty acid (DHA) in the regulation of colon cell growth and cell death: A review
JF - BIOMEDICAL PAPERS-OLOMOUC
VL - 156
IS - 3
SP - 186-199
EP - 186-199
PB - PALACKY UNIV, MEDICAL FAC
SN - 12138118
KW - polyunsaturated fatty acids
KW - docosahexaenoic acid
KW - colon cancer
KW - apoptosis
KW - cell signalling
KW - anticancer therapy
N2 - Background. Experimental, epidemiological and clinical data substantiate the beneficial role of n-3 polyunsaturated fatty acids (PUFAs) in preventing inflammation and cancer of the colon. This review covers the unsaturated docosahexaenoic fatty acid (DHA), describes some of its important cellular and molecular mechanisms, its interaction with another dietary lipid, butyrate and with endogenous apoptotic regulators of the tumour necrosis factor (TNF) family. We also discuss the clinical impact of this knowledge and the use of these lipids in colon cancer prevention and treatment. Results. From the literature, DHA has been shown to suppress the growth, induce apoptosis in colon cancer cells in vitro and decrease the incidence and growth of experimental tumours in vivo. Based on these data and our own experimental results, we describe and discuss the possible mechanisms of DHA anticancer effects at various levels of cell organization. We show that DHA can sensitize colon cancer cells to other chemotherapeutic/chemopreventive agents and affect the action of physiological apoptotic regulators of the TNF family. Conclusion. Use of n-3 PUFAs could be a relatively non-toxic form of supportive therapy for improving colon cancer treatment and slowing down or preventing its recurrence. However, it is necessary to use them with caution, based on solid scientific evidence of their mechanisms of action from the molecular to the cellular and organism levels.
ER -
SKENDER, Belma, Jiřina HOFMANOVÁ and Alena VACULOVÁ HYRŠLOVÁ. Docosahexaenoic fatty acid (DHA) in the regulation of colon cell growth and cell death: A review. \textit{BIOMEDICAL PAPERS-OLOMOUC}. OLOMOUC: PALACKY UNIV, MEDICAL FAC, 2012, vol.~156, No~3, p.~186-199. ISSN~1213-8118. Available from: https://dx.doi.org/10.5507/bp.2012.093.
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