J 2012

Grey-white matter abnormalities in temporal lobe epilepsy associated with hippocampal sclerosis: Inter-observer analysis, histopathological findings, and correlation with clinical variables

KUBA, Robert, Ivana TYRLÍKOVÁ, Marta PAŽOURKOVÁ, Markéta HERMANOVÁ, Iva HORÁKOVÁ et. al.

Basic information

Original name

Grey-white matter abnormalities in temporal lobe epilepsy associated with hippocampal sclerosis: Inter-observer analysis, histopathological findings, and correlation with clinical variables

Authors

KUBA, Robert (203 Czech Republic, guarantor, belonging to the institution), Ivana TYRLÍKOVÁ (203 Czech Republic, belonging to the institution), Marta PAŽOURKOVÁ (203 Czech Republic, belonging to the institution), Markéta HERMANOVÁ (203 Czech Republic, belonging to the institution), Iva HORÁKOVÁ (203 Czech Republic, belonging to the institution), Milan BRÁZDIL (203 Czech Republic, belonging to the institution) and Ivan REKTOR (203 Czech Republic, belonging to the institution)

Edition

Epilepsy Research, Amsterdam, Elsevier Science Publishers, 2012, 0920-1211

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30000 3. Medical and Health Sciences

Country of publisher

Netherlands

Confidentiality degree

není předmětem státního či obchodního tajemství

Impact factor

Impact factor: 2.241

RIV identification code

RIV/00216224:14110/12:00062715

Organization unit

Faculty of Medicine

DOI

UT WoS

000311529400009

Keywords in English

Grey-white matter abnormalities; Temporal lobe epilepsy; Focal cortical dysplasia; MRI

Tags

International impact
Změněno: 22/4/2013 18:21, Ing. Mgr. Věra Pospíšilíková

Abstract

V originále

This study was conducted to determine the incidence of grey-white matter abnormalities (GWMAs) on magnetic resonance images (MRIs) in patients with hippocampal sclerosis (HS), to assess the inter-observer reliability of this finding, and to establish a possible relationship between GWMA and histopathological findings in the anterior part of the temporal lobe, as well as its other relation to clinical variables. We established a group of 55 patients with histologically proven HS. Three observers independently reviewed the MRIs to assess whether GWMA was present. Substantial independent inter-observer agreement was reached for 44 of the 55 patients (80%) (Fleiss' kappa 0.732; p<0.0001). GWMAs were present in 38% of patients (HS + GWMA). Focal cortical dysplasia (FCD) of type Illa (ILAE classification) was present in 31% of patients. FCD type Illa was present in 52.4% with HS + GWMA, and in 17.6% without GWMA (HS - GWMA) (p=0.007). We did not find any statistically significant differences in the postoperative outcomes between HS + GWMA and HS - GWMA. We did not find any statistically significant differences in the presence or absence of GWMA and FCD of the temporal pole in relation to the onset of epilepsy, the duration of epilepsy, or the presence of potential epileptogenic insults. GWMA in the anterior part of temporal lobe in patients with HS is a reliable assessment sign for observers who are experienced in evaluating the MRIs of epilepsy patients. The presence of GWMA is significantly associated with the presence of FCD type Illa in these patients. The presence or absence of GWMA and FCD type Illa does not influence the postoperative outcome of HS patients. (C) 2012 Elsevier B.V. All rights reserved.