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@article{1081882,
author = {Šlaisová, Radka and Benda, Karel and Jarkovský, Jiří and Petrášová, Hana and Szturz, Petr and Válek, Vlastimil},
article_location = {CLARE},
article_number = {4},
doi = {http://dx.doi.org/10.1016/j.ejrad.2012.12.008},
keywords = {Lymph nodes; Ultrasonography; Color Doppler; Contrast media},
language = {eng},
issn = {0720-048X},
journal = {European Journal of Radiology},
title = {Contrast-enhanced ultrasonography compared to gray-scale and power doppler in the diagnosis of peripheral lymphadenopathy},
url = {http://dx.doi.org/10.1016/j.ejrad.2012.12.008},
volume = {82},
year = {2013}
}
TY - JOUR
ID - 1081882
AU - Šlaisová, Radka - Benda, Karel - Jarkovský, Jiří - Petrášová, Hana - Szturz, Petr - Válek, Vlastimil
PY - 2013
TI - Contrast-enhanced ultrasonography compared to gray-scale and power doppler in the diagnosis of peripheral lymphadenopathy
JF - European Journal of Radiology
VL - 82
IS - 4
SP - 693-698
EP - 693-698
PB - ELSEVIER IRELAND LTD
SN - 0720048X
KW - Lymph nodes
KW - Ultrasonography
KW - Color Doppler
KW - Contrast media
UR - http://dx.doi.org/10.1016/j.ejrad.2012.12.008
L2 - http://dx.doi.org/10.1016/j.ejrad.2012.12.008
N2 - Objectives: The aim of the study was to evaluate the ability of contrast-enhanced ultrasonography compared to gray-scale B-mode and power Doppler in distinction between benign and malignant lymphadenopathy. Methods: In a prospective study ultrasonography was performed in 133 patients with superficial lymphadenopathy (73 men, 60 women; mean age of 51 years, range: 18-86 years), who were examined for palpable mass in the neck, axilla or groin (104/133) and for clinical suspicion of lymphoma on the basis of positive PET/CT (29/133). 133 nodes were examined, subsequently preoperatively localized under ultrasound guidance and surgically removed; longitudinal to transverse ratio, location of nodal vessels by power Doppler and pattern of enhancement by contrast-enhanced ultrasonography with 1.5 ml intravenous bolus of sulphur hexafluoride contrast agent were documented. The ultrasound findings were compared with the histology. Results: Of all the nodes extirpated, 33 were benign, 100 were malignant (40 metastases, 60 lymphomas). Sensitivity, specificity, positive predictive value, negative predictive value and accuracy of conventional techniques were 72%, 63.6%, 85.7%, 42.9%, 67.8% for longitudinal to transverse ratio; 73%, 60.6%, 84.9%, 42.6%, 68.3% for power Doppler versus 98.0%, 54.5%, 86.7%, 90.0%, 76.3% for contrast-enhanced ultrasonography according to Receiver Operating Characteristic analysis. Conclusions: Receiver Operating Characteristic analysis confirmed higher degree of diagnostic accuracy of contrast-enhanced ultrasonography in comparison with conventional techniques. Evaluation of nodal perfusion after intravenous administration of microbubble contrast agent can be helpful in differentiation of benign from malignant nodes.
ER -
ŠLAISOVÁ, Radka, Karel BENDA, Jiří JARKOVSKÝ, Hana PETRÁŠOVÁ, Petr SZTURZ a Vlastimil VÁLEK. Contrast-enhanced ultrasonography compared to gray-scale and power doppler in the diagnosis of peripheral lymphadenopathy. \textit{European Journal of Radiology}. CLARE: ELSEVIER IRELAND LTD, 2013, roč.~82, č.~4, s.~693-698. ISSN~0720-048X. Dostupné z: https://dx.doi.org/10.1016/j.ejrad.2012.12.008.
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