| ŽOURKOVÁ, Alexandra, Ondřej SLANAŘ, Jiří JARKOVSKÝ, Ivana PALČÍKOVÁ, Eva PINDUROVÁ a Michaela CVANOVÁ. MDR1 in Paroxetine-Induced Sexual Dysfunction. Journal of Sex and Marital Therapy. USA: Taylor and Francis Health Sciences, 2013, roč. 39, č. 1, s. 71-78. ISSN 0092-623X. Dostupné z: https://dx.doi.org/10.1080/0092623X.2012.668514. |
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@article{1084923,
author = {Žourková, Alexandra and Slanař, Ondřej and Jarkovský, Jiří and Palčíková, Ivana and Pindurová, Eva and Cvanová, Michaela},
article_location = {USA},
article_number = {1},
doi = {http://dx.doi.org/10.1080/0092623X.2012.668514},
keywords = {P-GLYCOPROTEIN; MDR1; Sexual Dysfunction},
language = {eng},
issn = {0092-623X},
journal = {Journal of Sex and Marital Therapy},
title = {MDR1 in Paroxetine-Induced Sexual Dysfunction},
url = {http://www.tandfonline.com/doi/pdf/10.1080/0092623X.2012.668514},
volume = {39},
year = {2013}
}
TY - JOUR
ID - 1084923
AU - Žourková, Alexandra - Slanař, Ondřej - Jarkovský, Jiří - Palčíková, Ivana - Pindurová, Eva - Cvanová, Michaela
PY - 2013
TI - MDR1 in Paroxetine-Induced Sexual Dysfunction
JF - Journal of Sex and Marital Therapy
VL - 39
IS - 1
SP - 71-78
EP - 71-78
PB - Taylor and Francis Health Sciences
SN - 0092623X
KW - P-GLYCOPROTEIN
KW - MDR1
KW - Sexual Dysfunction
UR - http://www.tandfonline.com/doi/pdf/10.1080/0092623X.2012.668514
N2 - Paroxetine-induced sexual dysfunction represents a frequent treatment complication of otherwise efficient antidepressants. The genetic polymorphism of pharmacokinetic genes may contribute to the occurrence of such dysfunctions. This study presents the effect of MDR1 gene polymorphisms on sexual function in 18 women with bulimia nervosa, 18 women with anxiety disorders, and 19 healthy control subjects. It also deals with the relation between MDR1 gene polymorphisms and paroxetine-induced sexual dysfunction. The results demonstrated that MDR1 G2677T/A gene polymorphism allele carriers treated with paroxetine presented with difficulties with orgasm (p = .008) and lubrication (p < .001).
ER -
ŽOURKOVÁ, Alexandra, Ondřej SLANAŘ, Jiří JARKOVSKÝ, Ivana PALČÍKOVÁ, Eva PINDUROVÁ a Michaela CVANOVÁ. MDR1 in Paroxetine-Induced Sexual Dysfunction. \textit{Journal of Sex and Marital Therapy}. USA: Taylor and Francis Health Sciences, 2013, roč.~39, č.~1, s.~71-78. ISSN~0092-623X. Dostupné z: https://dx.doi.org/10.1080/0092623X.2012.668514.
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