Neuro-immune interactions: the concept of Yin Yang for
reinnervation and induction of neuropathic pain

p 2012

Neuro-immune interactions: the concept of Yin Yang for reinnervation and induction of neuropathic pain

DUBOVÝ, Petr, Radim JANČÁLEK, Ivana HRADILOVÁ SVÍŽENSKÁ a Ilona KLUSÁKOVÁ

Základní údaje

Originální název

Neuro-immune interactions: the concept of Yin Yang for reinnervation and induction of neuropathic pain

Název česky

Neuro-imunitní vztahy: pojem jin a jang v souvislosti s reinervací poškozeného periferního nervu a indukcí neuropatické bolesti

Autoři

DUBOVÝ, Petr, Radim JANČÁLEK, Ivana HRADILOVÁ SVÍŽENSKÁ a Ilona KLUSÁKOVÁ

Vydání

European winter conference on brain research, 2012

Další údaje

Typ výsledku

Vyžádané přednášky

Obor

30000 3. Medical and Health Sciences

Utajení

není předmětem státního či obchodního tajemství

Organizační jednotka

Středoevropský technologický institut

Klíčová slova česky

Jin a jang; Wallerova degenerace; regenerace poškozených axonů; neuropatická bolest

Klíčová slova anglicky

Yin and yang; Wallerian degeneration; regeneration of damaged axons; neuropathic pain

Příznaky

Mezinárodní význam

Změněno: 23. 12. 2013 15:22, prof. RNDr. Petr Dubový, CSc.

Anotace

V originále

In Asian philosophy, the concept of yin yang is used to describe how seemingly contrary forces are interconnected and interdependent in the natural world, and how they give rise to each other in turn. Opposites thus only exist in relation to each other. Wallerian degeneration is a cascade of stereotype cellular events and molecular alterations in distal reaction to injury of nerve fibers. These events consist of Schwann cells activation, immune cells invasion, up-regulation of neurotrophins and cytokines. The processes prepare essentially conditions for regeneration of damaged axons and restoration of their connections. The invaded macrophages remove myelin debris containing non-permissive molecules for axon growth and activated Schwann cells up-regulate neurotrophins and other molecules supporting axon growth. In addition, activated Schwann cells, recruited macrophages and invaded immune cells produce inflammatory mediators like cytokines and chemokines. Therefore, Wallerian degeneration is considered to be neuroinflammation preparing conditions for neuropathic pain induction. Thus, cellular and molecular events distal to nerve injury prepare simultaneously conditions for both axon regeneration and neuropathic pain induction. The activated Schwann cells are robust source for neurotrophins and immune mediators like cytokines and chemokines. However, interrelations of neurotrophins and immune mediators and their possible complementary, synergistic or antagonistic involvements in axon regeneration and/or neuropathic pain induction are recently obscure. Some recent knowledge on this topic is stressed. Both beneficial and detrimental effects of the immune signal molecules like cytokines, chemokines and transcription factors distal to nerve injury have to be considered in a strategy of axon regeneration promotion on one side and suppression of the initial stages of neuropathic pain on other side.

Návaznosti

ED1.1.00/02.0068, projekt VaV

Název: CEITEC - central european institute of technology

Citovat

DUBOVÝ, Petr, Radim JANČÁLEK, Ivana HRADILOVÁ SVÍŽENSKÁ a Ilona KLUSÁKOVÁ. Neuro-immune interactions: the concept of Yin Yang for reinnervation and induction of neuropathic pain. In European winter conference on brain research. 2012.

@misc{1085357,
   author = {Dubový, Petr and Jančálek, Radim and Hradilová Svíženská, Ivana and Klusáková, Ilona},
   booktitle = {European winter conference on brain research},
   keywords = {Yin and yang; Wallerian degeneration; regeneration of damaged axons; neuropathic pain},
   title = {Neuro-immune interactions: the concept of Yin Yang for reinnervation and induction of neuropathic pain},
   year = {2012}
}

TY  - SLIDE
ID  - 1085357
AU  - Dubový, Petr - Jančálek, Radim - Hradilová Svíženská, Ivana - Klusáková, Ilona
PY  - 2012
TI  - Neuro-immune interactions: the concept of Yin Yang for reinnervation and induction of neuropathic pain
KW  - Yin and yang
KW  - Wallerian degeneration
KW  - regeneration of damaged axons
KW  - neuropathic pain
N2  - In Asian philosophy, the concept of yin yang is used to describe how seemingly contrary forces are interconnected and interdependent in the natural world, and how they give rise to each other in turn. Opposites thus only exist in relation to each other. Wallerian degeneration is a cascade of stereotype cellular events and molecular alterations in distal reaction to injury of nerve fibers. These events consist of Schwann cells activation, immune cells invasion, up-regulation of neurotrophins and cytokines. The processes prepare essentially conditions for regeneration of damaged axons and restoration of their connections. The invaded macrophages remove myelin debris containing non-permissive molecules for axon growth and activated Schwann cells up-regulate neurotrophins and other molecules supporting axon growth. In addition, activated Schwann cells, recruited macrophages and invaded immune cells produce inflammatory mediators like cytokines and chemokines. Therefore, Wallerian degeneration is considered to be neuroinflammation preparing conditions for neuropathic pain induction. Thus, cellular and molecular events distal to nerve injury prepare simultaneously conditions for both axon regeneration and neuropathic pain induction. The activated Schwann cells are robust source for neurotrophins and immune mediators like cytokines and chemokines. However, interrelations of neurotrophins and immune mediators and their possible complementary, synergistic or antagonistic involvements in axon regeneration and/or neuropathic pain induction are recently obscure. Some recent knowledge on this topic is stressed. Both beneficial and detrimental effects of the immune signal molecules like cytokines, chemokines and transcription factors distal to nerve injury have to be considered in a strategy of axon regeneration promotion on one side and suppression of the initial stages of neuropathic pain on other side.
ER  -

DUBOVÝ, Petr, Radim JANČÁLEK, Ivana HRADILOVÁ SVÍŽENSKÁ a Ilona KLUSÁKOVÁ. Neuro-immune interactions: the concept of Yin Yang for reinnervation and induction of neuropathic pain. In \textit{European winter conference on brain research}. 2012.

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