Mutual cytokine crosstalk between colon cancer cells and
microenvironment initiates development of distant metastases

J 2013

Mutual cytokine crosstalk between colon cancer cells and microenvironment initiates development of distant metastases

VAŇHARA, Petr a Karel SOUČEK

Základní údaje

Originální název

Mutual cytokine crosstalk between colon cancer cells and microenvironment initiates development of distant metastases

Autoři

VAŇHARA, Petr (203 Česká republika, domácí) a Karel SOUČEK (203 Česká republika, garant)

Vydání

JAK-STAT, London, Landes Bioscience, 2013, 2162-3996

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

Genetika a molekulární biologie

Stát vydavatele

Velká Británie a Severní Irsko

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Kód RIV

RIV/00216224:14110/13:00067733

Organizační jednotka

Lékařská fakulta

DOI

http://dx.doi.org/10.4161/jkst.23810

Klíčová slova anglicky

metastasis; transforming growth factor-b; interleukin 11; metastatic niche; tumor stroma; dissemination; microenvironment

Změněno: 28. 3. 2014 16:43, Ing. Mgr. Věra Pospíšilíková

Anotace

V originále

Tumor growth and cancer development are considered clear examples of Darwinian selection, whereby random mutational events in heterogeneous cancer cell populations that best fit the selective microenvironment are preferred.1 As a result, cancer cells evolve resistance to apoptosis, hide from immune surveillance and acquire the ability to invade other organs. Cancer cells, however, are not necessarily passive subjects of selection; they can actively subvert the host tissue to provide a favorable habitat for their growth. Recent findings by Calon et al. convincingly demonstrate that transforming growth factor-b-induced secretion of interleukin 11 by tumor stromal fibroblasts is a necessary prerequisite for the development of distant metastases in colorectal carcinoma. Thus, understanding the complex molecular feedback loops between cancer cells and the surrounding microenvironment (i.e., the tumor-associated stroma or invaded host tissue) should aid the identification of useful molecular targets for improving clinical management of advanced metastatic cancers.

Návaznosti

7AMB12AT019, projekt VaV

Název: Studium molekulární podstaty nových tumorových markerů u ovariálních a prostatických karcinomů (Akronym: Biomarkers)

Investor: Ministerstvo školství, mládeže a tělovýchovy ČR, Studium molekulární podstaty nových tumorových markerů u ovariálních a prostatických karcinomů

Citovat

VAŇHARA, Petr a Karel SOUČEK. Mutual cytokine crosstalk between colon cancer cells and microenvironment initiates development of distant metastases. JAK-STAT. London: Landes Bioscience, 2013, roč. 2, č. 2, s. 1-4. ISSN 2162-3996. Dostupné z: https://dx.doi.org/10.4161/jkst.23810.

@article{1085782,
   author = {Vaňhara, Petr and Souček, Karel},
   article_location = {London},
   article_number = {2},
   doi = {http://dx.doi.org/10.4161/jkst.23810},
   keywords = {metastasis; transforming growth factor-b; interleukin 11; metastatic niche; tumor stroma; dissemination; microenvironment},
   language = {eng},
   issn = {2162-3996},
   journal = {JAK-STAT},
   title = {Mutual cytokine crosstalk between colon cancer cells and microenvironment initiates development of distant metastases},
   url = {https://www.landesbioscience.com/journals/jak-stat/2012JAKS0099.pdf},
   volume = {2},
   year = {2013}
}

TY  - JOUR
ID  - 1085782
AU  - Vaňhara, Petr - Souček, Karel
PY  - 2013
TI  - Mutual cytokine crosstalk between colon cancer cells and microenvironment initiates development of distant metastases
JF  - JAK-STAT
VL  - 2
IS  - 2
SP  - 1-4
EP  - 1-4
PB  - Landes Bioscience
SN  - 21623996
KW  - metastasis
KW  - transforming growth factor-b
KW  - interleukin 11
KW  - metastatic niche
KW  - tumor stroma
KW  - dissemination
KW  - microenvironment
UR  - https://www.landesbioscience.com/journals/jak-stat/2012JAKS0099.pdf
N2  - Tumor growth and cancer development are considered clear examples of Darwinian selection, whereby random mutational events in heterogeneous cancer cell populations that best fit the selective microenvironment are preferred.1 As a result, cancer cells evolve resistance to apoptosis, hide from immune surveillance and acquire the ability to invade other organs. Cancer cells, however, are not necessarily passive subjects of selection; they can actively subvert the host tissue to provide a favorable habitat for their growth. Recent findings by Calon et al. convincingly demonstrate that transforming growth factor-b-induced secretion of interleukin 11 by tumor stromal fibroblasts is a necessary prerequisite for the development of distant metastases in colorectal carcinoma. Thus, understanding the complex molecular feedback loops between cancer cells and the surrounding microenvironment (i.e., the tumor-associated stroma or invaded host tissue) should aid the identification of useful molecular targets for improving clinical management of advanced metastatic cancers.
ER  -

VAŇHARA, Petr a Karel SOUČEK. Mutual cytokine crosstalk between colon cancer cells and microenvironment initiates development of distant metastases. \textit{JAK-STAT}. London: Landes Bioscience, 2013, roč.~2, č.~2, s.~1-4. ISSN~2162-3996. Dostupné z: https://dx.doi.org/10.4161/jkst.23810.

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