Detailed Information on Publication Record
2013
Mutual cytokine crosstalk between colon cancer cells and microenvironment initiates development of distant metastases
VAŇHARA, Petr and Karel SOUČEKBasic information
Original name
Mutual cytokine crosstalk between colon cancer cells and microenvironment initiates development of distant metastases
Authors
VAŇHARA, Petr (203 Czech Republic, belonging to the institution) and Karel SOUČEK (203 Czech Republic, guarantor)
Edition
JAK-STAT, London, Landes Bioscience, 2013, 2162-3996
Other information
Language
English
Type of outcome
Článek v odborném periodiku
Field of Study
Genetics and molecular biology
Country of publisher
United Kingdom of Great Britain and Northern Ireland
Confidentiality degree
není předmětem státního či obchodního tajemství
References:
RIV identification code
RIV/00216224:14110/13:00067733
Organization unit
Faculty of Medicine
Keywords in English
metastasis; transforming growth factor-b; interleukin 11; metastatic niche; tumor stroma; dissemination; microenvironment
Změněno: 28/3/2014 16:43, Ing. Mgr. Věra Pospíšilíková
Abstract
V originále
Tumor growth and cancer development are considered clear examples of Darwinian selection, whereby random mutational events in heterogeneous cancer cell populations that best fit the selective microenvironment are preferred.1 As a result, cancer cells evolve resistance to apoptosis, hide from immune surveillance and acquire the ability to invade other organs. Cancer cells, however, are not necessarily passive subjects of selection; they can actively subvert the host tissue to provide a favorable habitat for their growth. Recent findings by Calon et al. convincingly demonstrate that transforming growth factor-b-induced secretion of interleukin 11 by tumor stromal fibroblasts is a necessary prerequisite for the development of distant metastases in colorectal carcinoma. Thus, understanding the complex molecular feedback loops between cancer cells and the surrounding microenvironment (i.e., the tumor-associated stroma or invaded host tissue) should aid the identification of useful molecular targets for improving clinical management of advanced metastatic cancers.
Links
7AMB12AT019, research and development project |
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