Long-term vagus nerve stimulation in children with focal
epilepsy

J 2013

Long-term vagus nerve stimulation in children with focal epilepsy

RYZÍ, Michal, Milan BRÁZDIL, Zdeněk NOVÁK, Jan CHRASTINA, Hana OŠLEJŠKOVÁ et. al.

Základní údaje

Originální název

Long-term vagus nerve stimulation in children with focal epilepsy

Autoři

RYZÍ, Michal (203 Česká republika, garant, domácí), Milan BRÁZDIL (203 Česká republika, domácí), Zdeněk NOVÁK (203 Česká republika, domácí), Jan CHRASTINA (203 Česká republika, domácí), Hana OŠLEJŠKOVÁ (203 Česká republika, domácí), Ivan REKTOR (203 Česká republika, domácí) a Robert KUBA (203 Česká republika, domácí)

Vydání

ACTA NEUROLOGICA SCANDINAVICA, MALDEN, USA, WILEY-BLACKWELL, 2013, 0001-6314

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30000 3. Medical and Health Sciences

Stát vydavatele

Spojené státy

Utajení

není předmětem státního či obchodního tajemství

Impakt faktor

Impact factor: 2.437

Kód RIV

RIV/00216224:14110/13:00067788

Organizační jednotka

Lékařská fakulta

DOI

http://dx.doi.org/10.1111/ane.12009

UT WoS

000317859900006

Klíčová slova anglicky

child neurology; epilepsy; quality of life; seizures; treatment

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 27. 5. 2013 16:52, Ing. Mgr. Věra Pospíšilíková

Anotace

V originále

Objectives – The aim of the study was to evaluate the long-term efficacy and hospitalization rates in children with refractory focal epilepsy treated by vagus nerve stimulation. Materials and methods – We retrospectively analyzed 15 children with intractable focal epilepsy treated by vagus nerve stimulation (mean age of 14.6 +/- 2.5 years at the time of implantation). We analyzed the treatment effectiveness at 1, 2, and 5 year follow-up visits. We counted the average number of urgent hospitalizations and number of days of urgent hospitalization per year for each patient before and after the VNS implantation. Results – The mean seizure reduction was 42.5% at 1 year, 54.9% at 2 years, and 58.3% at 5 years. The number of responders was 7 (46.7%) at 1 year and 9 (60%) at both 2 and 5 years. The mean number of urgent hospitalizations per patient was 1.0 +/- 0.6 per year preoperatively and 0.3 +/- 0.5 per year post-operatively. The mean number of days of urgent hospitalization per patient was 9.3 +/- 6.1 per year preoperatively and 1.3 +/- 1.8 per year postoperatively. Conclusions – Vagus nerve stimulation is an effective method of treating children with refractory focal epilepsy. It leads to a substantial decrease in the number and duration of urgent hospitalizations.

Přiložené soubory

ans_vagal_child_pubmed.pdf

Požádat o autorskou verzi souboru

Citovat

RYZÍ, Michal, Milan BRÁZDIL, Zdeněk NOVÁK, Jan CHRASTINA, Hana OŠLEJŠKOVÁ, Ivan REKTOR a Robert KUBA. Long-term vagus nerve stimulation in children with focal epilepsy. ACTA NEUROLOGICA SCANDINAVICA. MALDEN, USA: WILEY-BLACKWELL, 2013, roč. 127, č. 5, s. 316-322. ISSN 0001-6314. Dostupné z: https://dx.doi.org/10.1111/ane.12009.

@article{1087789,
   author = {Ryzí, Michal and Brázdil, Milan and Novák, Zdeněk and Chrastina, Jan and Ošlejšková, Hana and Rektor, Ivan and Kuba, Robert},
   article_location = {MALDEN, USA},
   article_number = {5},
   doi = {http://dx.doi.org/10.1111/ane.12009},
   keywords = {child neurology; epilepsy; quality of life; seizures; treatment},
   language = {eng},
   issn = {0001-6314},
   journal = {ACTA NEUROLOGICA SCANDINAVICA},
   title = {Long-term vagus nerve stimulation in children with focal epilepsy},
   volume = {127},
   year = {2013}
}

TY  - JOUR
ID  - 1087789
AU  - Ryzí, Michal - Brázdil, Milan - Novák, Zdeněk - Chrastina, Jan - Ošlejšková, Hana - Rektor, Ivan - Kuba, Robert
PY  - 2013
TI  - Long-term vagus nerve stimulation in children with focal epilepsy
JF  - ACTA NEUROLOGICA SCANDINAVICA
VL  - 127
IS  - 5
SP  - 316-322
EP  - 316-322
PB  - WILEY-BLACKWELL
SN  - 00016314
KW  - child neurology
KW  - epilepsy
KW  - quality of life
KW  - seizures
KW  - treatment
N2  - Objectives – The aim of the study was to evaluate the long-term efficacy and hospitalization rates in children with refractory focal epilepsy treated by vagus nerve stimulation. Materials and methods – We retrospectively analyzed 15 children with intractable focal epilepsy treated by vagus nerve stimulation (mean age of 14.6 +/- 2.5 years at the time of implantation). We analyzed the treatment effectiveness at 1, 2, and 5 year follow-up visits. We counted the average number of urgent hospitalizations and number of days of urgent hospitalization per year for each patient before and after the VNS implantation. Results – The mean seizure reduction was 42.5% at 1 year, 54.9% at 2 years, and 58.3% at 5 years. The number of responders was 7 (46.7%) at 1 year and 9 (60%) at both 2 and 5 years. The mean number of urgent hospitalizations per patient was 1.0 +/- 0.6 per year preoperatively and 0.3 +/- 0.5 per year post-operatively. The mean number of days of urgent hospitalization per patient was 9.3 +/- 6.1 per year preoperatively and 1.3 +/- 1.8 per year postoperatively. Conclusions – Vagus nerve stimulation is an effective method of treating children with refractory focal epilepsy. It leads to a substantial decrease in the number and duration of urgent hospitalizations.
ER  -

RYZÍ, Michal, Milan BRÁZDIL, Zdeněk NOVÁK, Jan CHRASTINA, Hana OŠLEJŠKOVÁ, Ivan REKTOR a Robert KUBA. Long-term vagus nerve stimulation in children with focal epilepsy. \textit{ACTA NEUROLOGICA SCANDINAVICA}. MALDEN, USA: WILEY-BLACKWELL, 2013, roč.~127, č.~5, s.~316-322. ISSN~0001-6314. Dostupné z: https://dx.doi.org/10.1111/ane.12009.

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