Molecular Dynamics Simulations of RNA Molecules

C 2012

Molecular Dynamics Simulations of RNA Molecules

ŠPONER, Jiří; Michal OTYEPKA; Pavel BANÁŠ; Kamila RÉBLOVÁ; Nils WALTER et. al.

Basic information

Original name

Molecular Dynamics Simulations of RNA Molecules

Authors

ŠPONER, Jiří; Michal OTYEPKA; Pavel BANÁŠ; Kamila RÉBLOVÁ and Nils WALTER

Edition

1. vydání. Cambridge, Innovations in Biomolecular Modeling and Simulations, p. 129-155, 27 pp. Volume 2, 2012

Publisher

The Royal Society of Chemistry

Other information

Language

English

Type of outcome

Chapter(s) of a specialized book

Field of Study

10610 Biophysics

Country of publisher

United Kingdom of Great Britain and Northern Ireland

Confidentiality degree

is not subject to a state or trade secret

Publication form

printed version "print"

Organization unit

Central European Institute of Technology

ISBN

978-1-84973-462-2

Keywords (in Czech)

Molecular dynamics, RNA, RNP

Abstract

In the original language

The central role of RNA in numerous biological processes including translation, protein localization, gene regulation, RNA processing, and viral replication calls for a detailed understanding of RNA function, structure, and conformational dynamics. Accompanying and enhancing our increasing appreciation of RNA is the rapidly expanding availability of high-resolution structures of RNAs and RNA-protein (RNP) complexes. These atomic resolution snapshots provide detailed rationalization for existing biochemical data. However, biological function depends on the dynamic evolution of structures along functional pathways. A complete understanding of the relevant structural dynamics exhibited by RNA requires monitoring timescales from picoseconds to hours through the application of a correspondingly broad range of techniques, with careful consideration given to the scope and limitation of each approach.

Links

LC06030, research and development project

Name: Biomolekulární centrum

Investor: Ministry of Education, Youth and Sports of the CR, Biomolecular centre

Cite

ŠPONER, Jiří; Michal OTYEPKA; Pavel BANÁŠ; Kamila RÉBLOVÁ and Nils WALTER. Molecular Dynamics Simulations of RNA Molecules. In Tamar Schlick. Innovations in Biomolecular Modeling and Simulations. 1. vydání. Cambridge: The Royal Society of Chemistry, 2012, p. 129-155. Volume 2. ISBN 978-1-84973-462-2.

@inbook{1089137,
   author = {Šponer, Jiří and Otyepka, Michal and Banáš, Pavel and Réblová, Kamila and Walter, Nils},
   address = {Cambridge},
   booktitle = {Innovations in Biomolecular Modeling and Simulations},
   edition = {1. vydání},
   editor = {Tamar Schlick},
   howpublished = {tištěná verze "print"},
   language = {eng},
   location = {Cambridge},
   isbn = {978-1-84973-462-2},
   pages = {129-155},
   publisher = {The Royal Society of Chemistry},
   title = {Molecular Dynamics Simulations of RNA Molecules},
   year = {2012}
}

TY  - CHAP
ID  - 1089137
AU  - Šponer, Jiří - Otyepka, Michal - Banáš, Pavel - Réblová, Kamila - Walter, Nils
PY  - 2012
TI  - Molecular Dynamics Simulations of RNA Molecules
VL  - Volume 2
PB  - The Royal Society of Chemistry
CY  - Cambridge
SN  - 9781849734622
N2  - The central role of RNA in numerous biological processes including translation, protein localization, gene regulation, RNA processing, and viral replication calls for a detailed understanding of RNA function, structure, and conformational dynamics. Accompanying and enhancing our increasing appreciation of RNA is the rapidly expanding availability of high-resolution structures of RNAs and RNA-protein (RNP) complexes. These atomic resolution snapshots provide detailed rationalization for existing biochemical data. However, biological function depends on the dynamic evolution of structures along functional pathways. A complete understanding of the relevant structural dynamics exhibited by RNA requires monitoring timescales from picoseconds to hours through the application of a correspondingly broad range of techniques, with careful consideration given to the scope and limitation of each approach.
ER  -

ŠPONER, Jiří; Michal OTYEPKA; Pavel BANÁŠ; Kamila RÉBLOVÁ and Nils WALTER. Molecular Dynamics Simulations of RNA Molecules. In Tamar Schlick. \textit{Innovations in Biomolecular Modeling and Simulations}. 1. vydání. Cambridge: The Royal Society of Chemistry, 2012, p.~129-155. Volume 2. ISBN~978-1-84973-462-2.

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