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@article{1092006,
author = {Štourač, Petr and Křikava, Ivo and Seidlová, Judita and Straževská, Eva and Huser, Martin and Hruban, Lukáš and Janků, Petr and Gál, Roman},
article_location = {OXFORD},
article_number = {4},
doi = {http://dx.doi.org/10.1093/bja/aet037},
keywords = {sugammadex; myotonic dystrophy; Caesarean Section; General Anaesthesia},
language = {eng},
issn = {0007-0912},
journal = {British Journal of Anaesthesia},
title = {Sugammadex in a parturient with myotonic dystrophy},
volume = {110},
year = {2013}
}
TY - JOUR
ID - 1092006
AU - Štourač, Petr - Křikava, Ivo - Seidlová, Judita - Straževská, Eva - Huser, Martin - Hruban, Lukáš - Janků, Petr - Gál, Roman
PY - 2013
TI - Sugammadex in a parturient with myotonic dystrophy
JF - British Journal of Anaesthesia
VL - 110
IS - 4
SP - 657-658
EP - 657-658
PB - Oxford University Press
SN - 00070912
KW - sugammadex
KW - myotonic dystrophy
KW - Caesarean Section
KW - General Anaesthesia
N2 - Myotonic dystrophy is a chronic, slowly progressing, highly variable, inherited multisystemic disease. It is characterized by wasting of the muscles (muscular dystrophy), cataracts, heart conduction abnormalities, endocrine changes, slow gastric and bowel emptying, and myotonia. Patients with myotonic dystrophy show myotonic responses to succinylcholine and neostigmine, and increased sensitivity to non-depolarising muscle relaxants. We report two cases of a parturient with myotonic dystrophy scheduled for Caesarean Section under general anaesthesia, once in 2009 and once in 2011. Muscle relaxant anaesthetic management in 2009 consisted of rocuronium and waiting for spontaneous neuromuscular blockade recovery with arteficial ventilation in the intensive care unit for 2 hours and 30 minutes postoperatively. In 2011, the same patient was indicated for the selective binding agent sugammadex ( 4 mg kg-1) to actively reverse deep neuromuscular blockade at the end of surgery. Train of Four ratio 0.9 was achieved in 2 minutes. There was no exacerbation of myotonia and no recurrence of muscle relaxation perioperatively in either case. These two obstetric cases provide evidence for the benefits of sugammadex in patients with myotonic dystrophy. We also suggest that it could be used in other patients with neuromuscular diseases.
ER -
ŠTOURAČ, Petr, Ivo KŘIKAVA, Judita SEIDLOVÁ, Eva STRAŽEVSKÁ, Martin HUSER, Lukáš HRUBAN, Petr JANKŮ a Roman GÁL. Sugammadex in a parturient with myotonic dystrophy. \textit{British Journal of Anaesthesia}. OXFORD: Oxford University Press, 2013, roč.~110, č.~4, s.~657-658. ISSN~0007-0912. Dostupné z: https://dx.doi.org/10.1093/bja/aet037.
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