J 2012

The default mode network integrity in patients with Parkinson's disease is levodopa equivalent dose-dependent

KRAJČOVIČOVÁ, Lenka, Michal MIKL, Radek MAREČEK a Irena REKTOROVÁ

Základní údaje

Originální název

The default mode network integrity in patients with Parkinson's disease is levodopa equivalent dose-dependent

Autoři

KRAJČOVIČOVÁ, Lenka (703 Slovensko, domácí), Michal MIKL (203 Česká republika, domácí), Radek MAREČEK (203 Česká republika, domácí) a Irena REKTOROVÁ (203 Česká republika, garant, domácí)

Vydání

Journal of Neural Transmission, Vídeň, SPRINGER WIEN, 2012, 0300-9564

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30000 3. Medical and Health Sciences

Stát vydavatele

Rakousko

Utajení

není předmětem státního či obchodního tajemství

Odkazy

Impakt faktor

Impact factor: 3.052

Kód RIV

RIV/00216224:14740/12:00064606

Organizační jednotka

Středoevropský technologický institut

DOI

UT WoS

000302423900005

Klíčová slova anglicky

Parkinson's disease; Default mode network; Deactivation; Functional connectivity; Hippocampus; Levodopa

Štítky

Příznaky

Mezinárodní význam, Recenzováno
Změněno: 2. 4. 2013 09:05, Olga Křížová

Anotace

V originále

Disturbances in the default mode network (DMN) have been described in many neurological and psychiatric disorders including Parkinson's disease (PD). The DMN is characterized by basal activity that increases during rest or passive visual fixation and decreases ("deactivates'') during cognitive tasks. The network is believed to be involved in cognitive processes. We examined the DMN in PD patients on dopaminergic medication with normal cognitive performance compared to age-and gender-matched healthy controls (HC) using fMRI and three methodological procedures: independent component analysis of resting-state data, analysis of deactivation during a complex visual scene-encoding task, and seed-based functional connectivity analysis. In the PD group, we also studied the effect of dopaminergic medication on the DMN integrity. We did not find any difference between the PD and HC groups in the DMN, but using the daily levodopa equivalent dose as a covariate, we observed an enhanced functional connectivity of the DMN in the posterior cingulate cortex and decreased activation in the left parahippocampal gyrus during the cognitive task. We conclude that dopaminergic therapy has a specific effect on both the DMN integrity and task-related brain activations in cognitively unimpaired PD patients, and these effects seem to be dose-dependent.

Návaznosti

ED1.1.00/02.0068, projekt VaV
Název: CEITEC - central european institute of technology