Intracellular Release of Endocytosed Nanoparticles Upon a
Change of Ligand-Receptor Interaction

J 2012

Intracellular Release of Endocytosed Nanoparticles Upon a Change of Ligand-Receptor Interaction

VÁCHA, Robert, Francisco J. MARTINEZ-VERACOECHEA a Daan FRENKEL

Základní údaje

Originální název

Intracellular Release of Endocytosed Nanoparticles Upon a Change of Ligand-Receptor Interaction

Autoři

VÁCHA, Robert (203 Česká republika, garant, domácí), Francisco J. MARTINEZ-VERACOECHEA (826 Velká Británie a Severní Irsko) a Daan FRENKEL (826 Velká Británie a Severní Irsko)

Vydání

ACS Nano, WASHINGTON, American Chemical Society, 2012, 1936-0851

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

10403 Physical chemistry

Stát vydavatele

Spojené státy

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Impakt faktor

Impact factor: 12.062

Kód RIV

RIV/00216224:14740/12:00064625

Organizační jednotka

Středoevropský technologický institut

DOI

http://dx.doi.org/10.1021/nn303508c

UT WoS

000312563600020

Klíčová slova anglicky

cytosol release; late endosome; ligand-receptor interaction; phospholipid membrane; nanoparticle shape; molecular dynamics

Štítky

ok, rivok

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 3. 4. 2013 07:49, Olga Křížová

Anotace

V originále

During passive endocytosis, nanosized particles are initially encapsulated by a membrane separating it from the cytosol. Yet, in many applications the nanoparticles need to be in direct contact with the cytosol in order to be active. We report a simulation study that elucidates the physical mechanisms by which such nanoparticles can shed their bilayer coating. We find that nanoparticle release can be readily achieved by a pH-induced lowering of the attraction between nanoparticle and membrane only if the nanoparticle is either very small or nonspherical. Interestingly, we find that in the case of large spherical nanoparticles, the reduction of attraction needs to be accompanied by exerting an additional tension on the membrane (e.g., via nanoparticle expansion) to achieve release. We expect these findings will contribute to the rational design of drug delivery strategies via nanoparticles.

Návaznosti

ED1.1.00/02.0068, projekt VaV

Název: CEITEC - central european institute of technology

286154, interní kód MU

Název: SYLICA - Synergies of Life and Material Sciences to Create a New Future (Akronym: SYLICA)

Investor: Evropská unie, SYLICA - Synergies of Life and Material Sciences to Create a New Future, Kapacity

Citovat

VÁCHA, Robert, Francisco J. MARTINEZ-VERACOECHEA a Daan FRENKEL. Intracellular Release of Endocytosed Nanoparticles Upon a Change of Ligand-Receptor Interaction. ACS Nano. WASHINGTON: American Chemical Society, 2012, roč. 6, č. 12, s. 10598-10605. ISSN 1936-0851. Dostupné z: https://dx.doi.org/10.1021/nn303508c.

@article{1094399,
   author = {Vácha, Robert and MartinezandVeracoechea, Francisco J. and Frenkel, Daan},
   article_location = {WASHINGTON},
   article_number = {12},
   doi = {http://dx.doi.org/10.1021/nn303508c},
   keywords = {cytosol release; late endosome; ligand-receptor interaction; phospholipid membrane; nanoparticle shape; molecular dynamics},
   language = {eng},
   issn = {1936-0851},
   journal = {ACS Nano},
   title = {Intracellular Release of Endocytosed Nanoparticles Upon a Change of Ligand-Receptor Interaction},
   url = {http://pubs.acs.org/doi/abs/10.1021/nn303508c?mi=qryllt&af=R&pageSize=20&searchText=ATP},
   volume = {6},
   year = {2012}
}

TY  - JOUR
ID  - 1094399
AU  - Vácha, Robert - Martinez-Veracoechea, Francisco J. - Frenkel, Daan
PY  - 2012
TI  - Intracellular Release of Endocytosed Nanoparticles Upon a Change of Ligand-Receptor Interaction
JF  - ACS Nano
VL  - 6
IS  - 12
SP  - 10598-10605
EP  - 10598-10605
PB  - American Chemical Society
SN  - 19360851
KW  - cytosol release
KW  - late endosome
KW  - ligand-receptor interaction
KW  - phospholipid membrane
KW  - nanoparticle shape
KW  - molecular dynamics
UR  - http://pubs.acs.org/doi/abs/10.1021/nn303508c?mi=qryllt&af=R&pageSize=20&searchText=ATP
L2  - http://pubs.acs.org/doi/abs/10.1021/nn303508c?mi=qryllt&af=R&pageSize=20&searchText=ATP
N2  - During passive endocytosis, nanosized particles are initially encapsulated by a membrane separating it from the cytosol. Yet, in many applications the nanoparticles need to be in direct contact with the cytosol in order to be active. We report a simulation study that elucidates the physical mechanisms by which such nanoparticles can shed their bilayer coating. We find that nanoparticle release can be readily achieved by a pH-induced lowering of the attraction between nanoparticle and membrane only if the nanoparticle is either very small or nonspherical. Interestingly, we find that in the case of large spherical nanoparticles, the reduction of attraction needs to be accompanied by exerting an additional tension on the membrane (e.g., via nanoparticle expansion) to achieve release. We expect these findings will contribute to the rational design of drug delivery strategies via nanoparticles.
ER  -

VÁCHA, Robert, Francisco J. MARTINEZ-VERACOECHEA a Daan FRENKEL. Intracellular Release of Endocytosed Nanoparticles Upon a Change of Ligand-Receptor Interaction. \textit{ACS Nano}. WASHINGTON: American Chemical Society, 2012, roč.~6, č.~12, s.~10598-10605. ISSN~1936-0851. Dostupné z: https://dx.doi.org/10.1021/nn303508c.

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