Assessment of risk factors for early post-partum conversion of
gestational diabetes mellitus to permanent diabetes mellitus or
persistent impaired glucose tolerance in Czech Republic

a 2013

Assessment of risk factors for early post-partum conversion of gestational diabetes mellitus to permanent diabetes mellitus or persistent impaired glucose tolerance in Czech Republic

BARTÁKOVÁ, Vendula, Denisa MALÚŠKOVÁ, Jan MUŽÍK, Jana BĚLOBRÁDKOVÁ, Kateřina KAŇKOVÁ et. al.

Základní údaje

Originální název

Assessment of risk factors for early post-partum conversion of gestational diabetes mellitus to permanent diabetes mellitus or persistent impaired glucose tolerance in Czech Republic

Název anglicky

Assessment of risk factors for early post-partum conversion of gestational diabetes mellitus to permanent diabetes mellitus or persistent impaired glucose tolerance in Czech Republic

Autoři

BARTÁKOVÁ, Vendula, Denisa MALÚŠKOVÁ, Jan MUŽÍK, Jana BĚLOBRÁDKOVÁ a Kateřina KAŇKOVÁ

Vydání

5th International Congress on Prediabetes and the Metabolic Syndrome, Vienna, Austria, April 18-20, 2013, in Journal of Diabetes, Volume 5, Suppl. 1, 2013

Další údaje

Typ výsledku

Konferenční abstrakt

Utajení

není předmětem státního či obchodního tajemství

Impakt faktor

Impact factor: 2.349

ISSN

Klíčová slova česky

gestační diabetes mellitus, oGTT, AUC, post partum diabetes mellitus

Klíčová slova anglicky

gestační diabetes mellitus, oGTT, AUC, post partum diabetes mellitus

Příznaky

Mezinárodní význam

Změněno: 22. 4. 2013 15:18, MUDr. Vendula Bartáková, Ph.D.

Anotace

V originále

Introduction Incidence of type 1 and 2 as well as gestational diabetes mellitus (GDM) are increasing worldwide. Given that women with previous GDM have a higher risk of diabetes development later in life compared to women with a physiological pregnancy, the aims of our study were (1) to ascertain a frequency of early postpartum conversion of GDM into permanent diabetes or persistent impaired glucose tolerance and (2) to find an eventual significant predictive factors from those routinely measured during the GDM follow up. Methods We carried out a retrospective epidemiological analysis of anamnestic, anthropometric, biochemical and clinical data of female patients (n=1090) from Faculty Hospital Brno with GDM diagnosis during the 2005 – 2011 period that underwent repeated oGTT up to 1 year after the delivery. Results Any degree of impairment of glucose tolerance postpartum was detected in 11.7% subjects, of those 4.1% had manifest DM (2.8% T2DM and 1.3% T1DM). Glycaemia in all three time-points of baseline oGTT, area under the curve (AUCoGTT) and baseline HbA1c were significantly associated (P<0.05, Mann-Whitney) with the postpartum disorder. Using regression analysis predictive risk model was developed using these baseline parameters. Conclusions Parameters of glucose metabolism measured during 24-28th week of pregnancy fulfilling criteria of GDM diagnosis exhibited highly statistically significant differences between women with and without persistent postpartum glucose metabolism abnormality and conferred significant predictive potential. Considering generally low-compliance of GDM women any more specific assessment of future risk stratifying GDM population could enable more effective screening of postpartum glucose metabolism disorder.

Návaznosti

MUNI/A/0839/2011, interní kód MU

Název: Patofyziologické aspekty vybraných genotypů a fenotypů komplexních nemocí (Akronym: Patofyziologie komplexních nemocí)

Investor: Masarykova univerzita, Patofyziologické aspekty vybraných genotypů a fenotypů komplexních nemocí, DO R. 2020_Kategorie A - Specifický výzkum - Studentské výzkumné projekty

NT11405, projekt VaV

Název: Mikrobiologické a genetické determinanty rozvoje a progrese parodontitidy u diabetiků 1. a 2. typu a jejich reciproční vztah ke kompenzaci diabetu

Investor: Ministerstvo zdravotnictví ČR, Mikrobiologické a genetické determinanty rozvoje a progrese parodontitidy u diabetiků 1. a 2. typu a jejich reciproční vztah ke kompenzaci diabetu

Citovat

BARTÁKOVÁ, Vendula, Denisa MALÚŠKOVÁ, Jan MUŽÍK, Jana BĚLOBRÁDKOVÁ a Kateřina KAŇKOVÁ. Assessment of risk factors for early post-partum conversion of gestational diabetes mellitus to permanent diabetes mellitus or persistent impaired glucose tolerance in Czech Republic. In 5th International Congress on Prediabetes and the Metabolic Syndrome, Vienna, Austria, April 18-20, 2013, in Journal of Diabetes, Volume 5, Suppl. 1. 2013. ISSN 1753-0393.

@proceedings{1103198,
   author = {Bartáková, Vendula and Malúšková, Denisa and Mužík, Jan and Bělobrádková, Jana and Kaňková, Kateřina},
   booktitle = {5th International Congress on Prediabetes and the Metabolic Syndrome, Vienna, Austria, April 18-20, 2013, in Journal of Diabetes, Volume 5, Suppl. 1},
   keywords = {gestační diabetes mellitus, oGTT, AUC, post partum diabetes mellitus},
   title = {Assessment of risk factors for early post-partum conversion of gestational diabetes mellitus to permanent diabetes mellitus or persistent impaired glucose tolerance in Czech Republic},
   year = {2013}
}

TY  - CONF
ID  - 1103198
AU  - Bartáková, Vendula - Malúšková, Denisa - Mužík, Jan - Bělobrádková, Jana - Kaňková, Kateřina
PY  - 2013
TI  - Assessment of risk factors for early post-partum conversion of gestational diabetes mellitus to permanent diabetes mellitus or persistent impaired glucose tolerance in Czech Republic
KW  - gestační diabetes mellitus, oGTT, AUC, post partum diabetes mellitus
N2  - Introduction Incidence of type 1 and 2 as well as gestational diabetes mellitus (GDM) are increasing worldwide. Given that women with previous GDM have a higher risk of diabetes development later in life compared to women with a physiological pregnancy, the aims of our study were (1) to ascertain a frequency of early postpartum conversion of GDM into permanent diabetes or persistent impaired glucose tolerance and (2) to find an eventual significant predictive factors from those routinely measured during the GDM follow up. Methods We carried out a retrospective epidemiological analysis of anamnestic, anthropometric, biochemical and clinical data of female patients (n=1090) from Faculty Hospital Brno with GDM diagnosis during the 2005 – 2011 period that underwent repeated oGTT up to 1 year after the delivery. Results Any degree of impairment of glucose tolerance postpartum was detected in 11.7% subjects, of those 4.1% had manifest DM (2.8% T2DM and 1.3% T1DM). Glycaemia in all three time-points of baseline oGTT, area under the curve (AUCoGTT) and baseline HbA1c were significantly associated (P<0.05, Mann-Whitney) with the postpartum disorder. Using regression analysis predictive risk model was developed using these baseline parameters. Conclusions Parameters of glucose metabolism measured during 24-28th week of pregnancy fulfilling criteria of GDM diagnosis exhibited highly statistically significant differences between women with and without persistent postpartum glucose metabolism abnormality and conferred significant predictive potential. Considering generally low-compliance of GDM women any more specific assessment of future risk stratifying GDM population could enable more effective screening of postpartum glucose metabolism disorder.
ER  -

BARTÁKOVÁ, Vendula, Denisa MALÚŠKOVÁ, Jan MUŽÍK, Jana BĚLOBRÁDKOVÁ a Kateřina KAŇKOVÁ. Assessment of risk factors for early post-partum conversion of gestational diabetes mellitus to permanent diabetes mellitus or persistent impaired glucose tolerance in Czech Republic. In \textit{5th International Congress on Prediabetes and the Metabolic Syndrome, Vienna, Austria, April 18-20, 2013, in Journal of Diabetes, Volume 5, Suppl. 1}. 2013. ISSN~1753-0393.

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