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@article{1103756,
author = {Bešše, Andrej and Šána, Jiří and Fadrus, Pavel and Slabý, Ondřej},
article_location = {Dordrecht},
article_number = {4},
doi = {http://dx.doi.org/10.1007/s13277-013-0772-5},
keywords = {microRNA; chemoresistance; radioresistance; high-grade gliomas},
language = {eng},
issn = {1010-4283},
journal = {Tumor Biology},
title = {MicroRNAs involved in chemo- and radioresistance of high-grade gliomas},
volume = {34},
year = {2013}
}
TY - JOUR
ID - 1103756
AU - Bešše, Andrej - Šána, Jiří - Fadrus, Pavel - Slabý, Ondřej
PY - 2013
TI - MicroRNAs involved in chemo- and radioresistance of high-grade gliomas
JF - Tumor Biology
VL - 34
IS - 4
SP - 1969-1978
EP - 1969-1978
PB - Springer
SN - 10104283
KW - microRNA
KW - chemoresistance
KW - radioresistance
KW - high-grade gliomas
N2 - High-grade gliomas (HGGs) are malignant primary brain tumors of glial cell origin. Despite optimal course of treatment, including maximal surgical resection followed by adjuvant chemo- and/or radiotherapy, the prognosis still remains poor. The main reason is the commonly occurring chemo- and radioresistance of these tumors. In recent years, several signaling pathways, especially PI3K/AKT and ATM/CHK2/p53, have been linked to the resistance of gliomas. Moreover, additional studies have shown that these pathways are significantly regulated by microRNAs (miRNAs), short endogenous RNA molecules that modulate gene expression and control many biological processes including apoptosis, proliferation, cell cycle, invasivity, and angiogenesis. MiRNAs are not only highly deregulated in gliomas, their expression signatures have also been shown to predict prognosis and therapy response. Therefore, they present promising biomarkers and therapeutic targets that might overcome the resistance to treatment and improve prognosis of glioma patients. In this review, we summarize the current knowledge of the functional role of miRNAs in gliomas resistance to chemo- and radiotherapy.
ER -
BEŠŠE, Andrej, Jiří ŠÁNA, Pavel FADRUS a Ondřej SLABÝ. MicroRNAs involved in chemo- and radioresistance of high-grade gliomas. \textit{Tumor Biology}. Dordrecht: Springer, 2013, roč.~34, č.~4, s.~1969-1978. ISSN~1010-4283. Dostupné z: https://dx.doi.org/10.1007/s13277-013-0772-5.
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