MicroRNAs involved in chemo- and radioresistance of high-grade
gliomas

J 2013

MicroRNAs involved in chemo- and radioresistance of high-grade gliomas

BEŠŠE, Andrej, Jiří ŠÁNA, Pavel FADRUS a Ondřej SLABÝ

Základní údaje

Originální název

MicroRNAs involved in chemo- and radioresistance of high-grade gliomas

Autoři

BEŠŠE, Andrej (703 Slovensko, domácí), Jiří ŠÁNA (203 Česká republika, domácí), Pavel FADRUS (203 Česká republika, domácí) a Ondřej SLABÝ (203 Česká republika, garant, domácí)

Vydání

Tumor Biology, Dordrecht, Springer, 2013, 1010-4283

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30200 3.2 Clinical medicine

Stát vydavatele

Švýcarsko

Utajení

není předmětem státního či obchodního tajemství

Impakt faktor

Impact factor: 2.840

Kód RIV

RIV/00216224:14740/13:00065588

Organizační jednotka

Středoevropský technologický institut

DOI

http://dx.doi.org/10.1007/s13277-013-0772-5

UT WoS

000321912500001

Klíčová slova anglicky

microRNA; chemoresistance; radioresistance; high-grade gliomas

Štítky

podil, rivok

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 5. 4. 2014 17:01, Olga Křížová

Anotace

V originále

High-grade gliomas (HGGs) are malignant primary brain tumors of glial cell origin. Despite optimal course of treatment, including maximal surgical resection followed by adjuvant chemo- and/or radiotherapy, the prognosis still remains poor. The main reason is the commonly occurring chemo- and radioresistance of these tumors. In recent years, several signaling pathways, especially PI3K/AKT and ATM/CHK2/p53, have been linked to the resistance of gliomas. Moreover, additional studies have shown that these pathways are significantly regulated by microRNAs (miRNAs), short endogenous RNA molecules that modulate gene expression and control many biological processes including apoptosis, proliferation, cell cycle, invasivity, and angiogenesis. MiRNAs are not only highly deregulated in gliomas, their expression signatures have also been shown to predict prognosis and therapy response. Therefore, they present promising biomarkers and therapeutic targets that might overcome the resistance to treatment and improve prognosis of glioma patients. In this review, we summarize the current knowledge of the functional role of miRNAs in gliomas resistance to chemo- and radiotherapy.

Návaznosti

ED1.1.00/02.0068, projekt VaV

Název: CEITEC - central european institute of technology

NT13514, projekt VaV

Název: Analýza mikroRNA v glioblastomových kmenových buňkách: predikce léčebné odpovědi a identifikace nových terapeutických cílů u pacientů s glioblastomem

Citovat

BEŠŠE, Andrej, Jiří ŠÁNA, Pavel FADRUS a Ondřej SLABÝ. MicroRNAs involved in chemo- and radioresistance of high-grade gliomas. Tumor Biology. Dordrecht: Springer, 2013, roč. 34, č. 4, s. 1969-1978. ISSN 1010-4283. Dostupné z: https://dx.doi.org/10.1007/s13277-013-0772-5.

@article{1103756,
   author = {Bešše, Andrej and Šána, Jiří and Fadrus, Pavel and Slabý, Ondřej},
   article_location = {Dordrecht},
   article_number = {4},
   doi = {http://dx.doi.org/10.1007/s13277-013-0772-5},
   keywords = {microRNA; chemoresistance; radioresistance; high-grade gliomas},
   language = {eng},
   issn = {1010-4283},
   journal = {Tumor Biology},
   title = {MicroRNAs involved in chemo- and radioresistance of high-grade gliomas},
   volume = {34},
   year = {2013}
}

TY  - JOUR
ID  - 1103756
AU  - Bešše, Andrej - Šána, Jiří - Fadrus, Pavel - Slabý, Ondřej
PY  - 2013
TI  - MicroRNAs involved in chemo- and radioresistance of high-grade gliomas
JF  - Tumor Biology
VL  - 34
IS  - 4
SP  - 1969-1978
EP  - 1969-1978
PB  - Springer
SN  - 10104283
KW  - microRNA
KW  - chemoresistance
KW  - radioresistance
KW  - high-grade gliomas
N2  - High-grade gliomas (HGGs) are malignant primary brain tumors of glial cell origin. Despite optimal course of treatment, including maximal surgical resection followed by adjuvant chemo- and/or radiotherapy, the prognosis still remains poor. The main reason is the commonly occurring chemo- and radioresistance of these tumors. In recent years, several signaling pathways, especially PI3K/AKT and ATM/CHK2/p53, have been linked to the resistance of gliomas. Moreover, additional studies have shown that these pathways are significantly regulated by microRNAs (miRNAs), short endogenous RNA molecules that modulate gene expression and control many biological processes including apoptosis, proliferation, cell cycle, invasivity, and angiogenesis. MiRNAs are not only highly deregulated in gliomas, their expression signatures have also been shown to predict prognosis and therapy response. Therefore, they present promising biomarkers and therapeutic targets that might overcome the resistance to treatment and improve prognosis of glioma patients. In this review, we summarize the current knowledge of the functional role of miRNAs in gliomas resistance to chemo- and radiotherapy.
ER  -

BEŠŠE, Andrej, Jiří ŠÁNA, Pavel FADRUS a Ondřej SLABÝ. MicroRNAs involved in chemo- and radioresistance of high-grade gliomas. \textit{Tumor Biology}. Dordrecht: Springer, 2013, roč.~34, č.~4, s.~1969-1978. ISSN~1010-4283. Dostupné z: https://dx.doi.org/10.1007/s13277-013-0772-5.

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