MicroRNAs involved in chemo- and radioresistance of high-grade gliomas

BEŠŠE, Andrej, Jiří ŠÁNA, Pavel FADRUS and Ondřej SLABÝ. MicroRNAs involved in chemo- and radioresistance of high-grade gliomas. Tumor Biology. Dordrecht: Springer, 2013, vol. 34, No 4, p. 1969-1978. ISSN 1010-4283. Available from: https://dx.doi.org/10.1007/s13277-013-0772-5.

Basic information

• Original name: MicroRNAs involved in chemo- and radioresistance of high-grade gliomas
• Authors: BEŠŠE, Andrej (703 Slovakia, belonging to the institution), Jiří ŠÁNA (203 Czech Republic, belonging to the institution), Pavel FADRUS (203 Czech Republic, belonging to the institution) and Ondřej SLABÝ (203 Czech Republic, guarantor, belonging to the institution).
• Edition: Tumor Biology, Dordrecht, Springer, 2013, 1010-4283.

Other information

• Original language: English
• Type of outcome: Article in a journal
• Field of Study: 30200 3.2 Clinical medicine
• Country of publisher: Switzerland
• Confidentiality degree: is not subject to a state or trade secret
• Impact factor: Impact factor: 2.840
• RIV identification code: RIV/00216224:14740/13:00065588
• Organization unit: Central European Institute of Technology
• Doi: http://dx.doi.org/10.1007/s13277-013-0772-5
• UT WoS: 000321912500001
• Keywords in English: microRNA; chemoresistance; radioresistance; high-grade gliomas
• Tags: podil, rivok
• Tags: International impact, Reviewed

Abstract

High-grade gliomas (HGGs) are malignant primary brain tumors of glial cell origin. Despite optimal course of treatment, including maximal surgical resection followed by adjuvant chemo- and/or radiotherapy, the prognosis still remains poor. The main reason is the commonly occurring chemo- and radioresistance of these tumors. In recent years, several signaling pathways, especially PI3K/AKT and ATM/CHK2/p53, have been linked to the resistance of gliomas. Moreover, additional studies have shown that these pathways are significantly regulated by microRNAs (miRNAs), short endogenous RNA molecules that modulate gene expression and control many biological processes including apoptosis, proliferation, cell cycle, invasivity, and angiogenesis. MiRNAs are not only highly deregulated in gliomas, their expression signatures have also been shown to predict prognosis and therapy response. Therefore, they present promising biomarkers and therapeutic targets that might overcome the resistance to treatment and improve prognosis of glioma patients. In this review, we summarize the current knowledge of the functional role of miRNAs in gliomas resistance to chemo- and radiotherapy.

Links

• ED1.1.00/02.0068, research and development project: Name: CEITEC - central european institute of technology
• NT13514, research and development project: Name: Analýza mikroRNA v glioblastomových kmenových buňkách: predikce léčebné odpovědi a identifikace nových terapeutických cílů u pacientů s glioblastomem