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@proceedings{1103989,
author = {Kleinová, Renata and Šána, Jiří and Dulavová, Eva and Křen, Leoš and Fadrus, Pavel and Slabý, Ondřej},
booktitle = {The Student Scientific Conference on Biotechnology & Biomedicine},
keywords = {microRNAs; glioblastoma multiforme; stem cells},
language = {eng},
isbn = {978-80-210-6200-9},
title = {Analysis of selected miRNAs in glioblastoma stem cells},
year = {2013}
}
TY - CONF
ID - 1103989
AU - Kleinová, Renata - Šána, Jiří - Dulavová, Eva - Křen, Leoš - Fadrus, Pavel - Slabý, Ondřej
PY - 2013
TI - Analysis of selected miRNAs in glioblastoma stem cells
SN - 9788021062009
KW - microRNAs
KW - glioblastoma multiforme
KW - stem cells
N2 - Glioblastoma multiforme (GBM) is the most frequent malignant brain tumor characterized by very poor prognosis. Despite a treatment based on maximal surgical resection followed by concomitant chemoradiotherapy with temozolomide and adjuvant temozolomide, the median of overall survival is less than 15 months from diagnosis. This is caused by a high resistance to the therapy that is attributed to small subpopulation of glioblastoma stem cells. Similar like non-cancer neuronal stem cells, they express markers of undifferentiated stem cell such as CD133. MicroRNAs are small, non-coding RNAs that function as post-transcription regulators of gene expression. Therefore, they play also key role in maintaining of glioblastoma stem cells phenotype including a resistance to the chemoradiotherapy.
ER -
KLEINOVÁ, Renata, Jiří ŠÁNA, Eva DULAVOVÁ, Leoš KŘEN, Pavel FADRUS a Ondřej SLABÝ. Analysis of selected miRNAs in glioblastoma stem cells. In \textit{The Student Scientific Conference on Biotechnology \&{} Biomedicine}. 2013. ISBN~978-80-210-6200-9.
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