2013
Expression analysis of microRNAs in relation to the chemoradioresistance of glioblastoma
KOSAŘOVÁ, Zdeňka; Jiří ŠÁNA; Andrej BEŠŠE; Radek LAKOMÝ; Martin SMRČKA et. al.Basic information
Original name
Expression analysis of microRNAs in relation to the chemoradioresistance of glioblastoma
Authors
KOSAŘOVÁ, Zdeňka (203 Czech Republic, belonging to the institution); Jiří ŠÁNA (203 Czech Republic, belonging to the institution); Andrej BEŠŠE (703 Slovakia, belonging to the institution); Radek LAKOMÝ (203 Czech Republic); Martin SMRČKA (203 Czech Republic); Rostislav VYZULA (203 Czech Republic) and Ondřej SLABÝ (203 Czech Republic, guarantor, belonging to the institution)
Edition
The Student Scientific Conference on Biotechnology & Biomedicine, 2013
Other information
Language
English
Type of outcome
Conference abstract
Field of Study
30200 3.2 Clinical medicine
Country of publisher
Czech Republic
Confidentiality degree
is not subject to a state or trade secret
RIV identification code
RIV/00216224:14740/13:00065596
Organization unit
Central European Institute of Technology
ISBN
978-80-210-6200-9
Keywords in English
microRNA; chemoresistance; radioresistance; glioblastoma multiforme
Changed: 25/4/2013 10:15, Mgr. Petra Vychytilová, Ph.D.
Abstract
In the original language
Glioblastoma multiforme (GBM) is the most frequent primary malignant brain tumor with very poor prognosis. Despite an optimal treatment composed of a maximal surgical resection followed an intense concomitant chemoradiotherapy with temozolomide and adjuvant temozolomide, the median of overall survival remains only 12-15 months from diagnosis. Because of a different response to treatment, it is very important to find new biomarkers that can be used in prediction of a clinical outcome in GBM patients, who underwent chemoradiotherapy. MicroRNAs are highly conserved, small, non-coding RNAs that function as post-transcriptional regulators of gene expression. Therefore, these molecules play key role in pathogenesis of many cancers, including GBM.
Links
| ED1.1.00/02.0068, research and development project |
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| NT13514, research and development project |
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