MicroRNAs in solid cancer: from biomarkers to therapeutic
targets

a 2013

MicroRNAs in solid cancer: from biomarkers to therapeutic targets

SLABÝ, Ondřej

Základní údaje

Originální název

MicroRNAs in solid cancer: from biomarkers to therapeutic targets

Autoři

SLABÝ, Ondřej (203 Česká republika, garant, domácí)

Vydání

The 9th Symposium & Workshop on Molecular Pathology and Histo(cyto)chemistry; The 99th Olomouc Seminar of the Czech division of the international academy of Pathology; The 5th Olomouc days of Histology Laboratory Technicians, 2013

Další údaje

Jazyk

angličtina

Typ výsledku

Konferenční abstrakt

Obor

30200 3.2 Clinical medicine

Stát vydavatele

Česká republika

Utajení

není předmětem státního či obchodního tajemství

Kód RIV

RIV/00216224:14740/13:00065597

Organizační jednotka

Středoevropský technologický institut

ISBN

978-80-7471-022-3

Klíčová slova anglicky

microRNAs; solid cancers; biomarkers; therapeutic targets

Změněno: 27. 1. 2014 17:22, Mgr. Petra Vychytilová, Ph.D.

Anotace

V originále

MicroRNAs (miRNAs) are small non-coding RNAs 18–25 nucleotides in length that downregulate gene expression during various crucial cell processes such as apoptosis, differentiation and development. Changes in the expression profiles of miRNAs have been observed in a variety of human solid tumors. Functional studies indicate that miRNAs act as tumor suppressors and oncogenes. These findings significantly extend concept of molecular pathogenesis of cancer and have shown great potential for miRNAs as a novel class of therapeutic targets. Several investigations have also described the ability of miRNA expression profiles to predict prognosis and response to selected treatments in cancer patients, and support diagnosis of origin among cancer of unknown primary site. MiRNAs’ occurrence has been repeatedly observed also in blood serum and plasma, and miRNAs as novel minimally invasive biomarkers have indicated reasonable sensitivity for cancer detection. This lecture covers introduction to miRNAs biology, miRNAs' involvement in the hallmarks of cancer, the knowledge regarding miRNAs' functioning in pathogenetic signaling pathways and their potential to serve as disease biomarkers and novel therapeutic targets in the colorectal cancer, renal cell carcinoma and glioblastoma in order to our recent observations.

Návaznosti

NT13514, projekt VaV

Název: Analýza mikroRNA v glioblastomových kmenových buňkách: predikce léčebné odpovědi a identifikace nových terapeutických cílů u pacientů s glioblastomem

NT13549, projekt VaV

Název: Vytvoření diagnostické sady cirkulujících mikroRNA pro neinvazivní časnou diagnostiku a sledování pacientů s kolorektálním karcinomem

Citovat

SLABÝ, Ondřej. MicroRNAs in solid cancer: from biomarkers to therapeutic targets. In The 9th Symposium & Workshop on Molecular Pathology and Histo(cyto)chemistry; The 99th Olomouc Seminar of the Czech division of the international academy of Pathology; The 5th Olomouc days of Histology Laboratory Technicians. 2013. ISBN 978-80-7471-022-3.

@proceedings{1104517,
   author = {Slabý, Ondřej},
   booktitle = {The 9th Symposium & Workshop on Molecular Pathology and Histo(cyto)chemistry; The 99th Olomouc Seminar of the Czech division of the international academy of Pathology; The 5th Olomouc days of Histology Laboratory Technicians},
   keywords = {microRNAs; solid cancers; biomarkers; therapeutic targets},
   language = {eng},
   isbn = {978-80-7471-022-3},
   title = {MicroRNAs in solid cancer: from biomarkers to therapeutic targets},
   year = {2013}
}

TY  - CONF
ID  - 1104517
AU  - Slabý, Ondřej
PY  - 2013
TI  - MicroRNAs in solid cancer: from biomarkers to therapeutic targets
SN  - 9788074710223
KW  - microRNAs
KW  - solid cancers
KW  - biomarkers
KW  - therapeutic targets
N2  - MicroRNAs (miRNAs) are small non-coding RNAs 18–25 nucleotides in length that downregulate gene expression during various crucial cell processes such as apoptosis, differentiation and development. Changes in the expression profiles of miRNAs have been observed in a variety of human solid tumors. Functional studies indicate that miRNAs act as tumor suppressors and oncogenes. These findings significantly extend concept of molecular pathogenesis of cancer and have shown great potential for miRNAs as a novel class of therapeutic targets. Several investigations have also described the ability of miRNA expression profiles to predict prognosis and response to selected treatments in cancer patients, and support diagnosis of origin among cancer of unknown primary site. MiRNAs’ occurrence has been repeatedly observed also in blood serum and plasma, and miRNAs as novel minimally invasive biomarkers have indicated reasonable sensitivity for cancer detection. This lecture covers introduction to miRNAs biology, miRNAs' involvement in the hallmarks of cancer, the knowledge regarding miRNAs' functioning in pathogenetic signaling pathways and their potential to serve as disease biomarkers and novel therapeutic targets in the colorectal cancer, renal cell carcinoma and glioblastoma in order to our recent observations.
ER  -

SLABÝ, Ondřej. MicroRNAs in solid cancer: from biomarkers to therapeutic targets. In \textit{The 9th Symposium \&{} Workshop on Molecular Pathology and Histo(cyto)chemistry; The 99th Olomouc Seminar of the Czech division of the international academy of Pathology; The 5th Olomouc days of Histology Laboratory Technicians}. 2013. ISBN~978-80-7471-022-3.

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