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@article{1104689,
author = {Trčka, Filip and Šmarda, Jan and Knopfová, Lucia and Kuziaková, Kateřina and Beneš, Petr},
article_location = {NEW YORK},
article_number = {7},
doi = {http://dx.doi.org/10.1016/j.cellsig.2013.03.021},
keywords = {Differentiation; Myeloid cells; NFAT1; Proliferation; Retinoic acid; v-Myb},
language = {eng},
issn = {0898-6568},
journal = {Cellular Signalling},
title = {Nuclear factor of activated T-cells 1 increases sensitivity of v-myb transformed monoblasts to all-trans retinoic acid},
volume = {25/2013},
year = {2013}
}
TY - JOUR
ID - 1104689
AU - Trčka, Filip - Šmarda, Jan - Knopfová, Lucia - Kuziaková, Kateřina - Beneš, Petr
PY - 2013
TI - Nuclear factor of activated T-cells 1 increases sensitivity of v-myb transformed monoblasts to all-trans retinoic acid
JF - Cellular Signalling
VL - 25/2013
IS - 7
SP - 1546-1555
EP - 1546-1555
PB - ELSEVIER SCIENCE INC
SN - 08986568
KW - Differentiation
KW - Myeloid cells
KW - NFAT1
KW - Proliferation
KW - Retinoic acid
KW - v-Myb
N2 - Nuclear factors of activated T-cells (NFATs) are important regulators of the cytokine gene expression in activated T-cells. In the last decade, NFATs have been shown to regulate cell cycle, differentiation and apoptosis in cells of various origins revealing their importance for cell homeostasis. In this study, we investigated the effects of NFAT1 on proliferation and differentiation of v-myb-transformed BM2 monoblasts. In contrast to many other leukemic cell lines, BM2 cells do not respond to retinoic acid. However, once overexpressing NFAT1, they became sensitive to all-trans retinoic acid (ATRA). The ATRA-treated BM2NFAT1 cells differentiated along monocyte/macrophage pathway as evidenced by changes in cell morphology, adherence, phagocytic and non-specific esterase activities, reactive oxygen species production, and vimentin expression. Furthermore, overexpressed NFAT1 either alone or in combination with the ATRA-driven signalling pathway deregulated cyclin A and retinoic acid receptor proteins in BM2 cells. Data presented in this study indicate that the NFAT1 and ATRA signalling pathways synergize in control of proliferation and differentiation of BM2 monoblasts.
ER -
TRČKA, Filip, Jan ŠMARDA, Lucia KNOPFOVÁ, Kateřina KUZIAKOVÁ and Petr BENEŠ. Nuclear factor of activated T-cells 1 increases sensitivity of v-myb transformed monoblasts to all-trans retinoic acid. \textit{Cellular Signalling}. NEW YORK: ELSEVIER SCIENCE INC, 2013, 25/2013, No~7, p.~1546-1555. ISSN~0898-6568. Available from: https://dx.doi.org/10.1016/j.cellsig.2013.03.021.
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