Microenvironment-dependent function of c-Myb in breast cancer: the focus on the tumor-endothelial cell interactions

KNOPFOVÁ, Lucia, Petr BENEŠ, Markéta HERMANOVÁ, Michal MASAŘÍK and Jan ŠMARDA. Microenvironment-dependent function of c-Myb in breast cancer: the focus on the tumor-endothelial cell interactions. In The 9th Symposium on Molecular Pathology and Histo(cyto)chemistry. 2013. ISBN 978-80-7471-022-3.

Basic information

• Original name: Microenvironment-dependent function of c-Myb in breast cancer: the focus on the tumor-endothelial cell interactions
• Name in Czech: Funkce c-Myb závislá na mikroprostředí u nádoru prsu: zaměření na interakce mezi buňkami nádoru a endothelu
• Authors: KNOPFOVÁ, Lucia (203 Czech Republic, belonging to the institution), Petr BENEŠ (203 Czech Republic, belonging to the institution), Markéta HERMANOVÁ (203 Czech Republic), Michal MASAŘÍK (203 Czech Republic) and Jan ŠMARDA (203 Czech Republic, guarantor, belonging to the institution).
• Edition: The 9th Symposium on Molecular Pathology and Histo(cyto)chemistry, 2013.

Other information

• Original language: English
• Type of outcome: Conference abstract
• Field of Study: 10601 Cell biology
• Country of publisher: Czech Republic
• Confidentiality degree: is not subject to a state or trade secret
• RIV identification code: RIV/00216224:14310/13:00065599
• Organization unit: Faculty of Science
• ISBN: 978-80-7471-022-3
• Keywords (in Czech): c-Myb; nádor prsu; mikroprostředí nádoru; invazivita
• Keywords in English: c-Myb; breast tumor; tumor microenvironment; invasivity

Abstract

Deregulation of c-Myb occurs frequently in breast cancer and other malignancies. We described that the Myb overexpression in breast carcinoma cell lines can differentially affect cell migration and invasion in vitro depending on chemotaktic/chemokinetic conditions and matrix composition. The Myb-overexpressing mammary tumors in syngeneic BALB/C model rarely metastasized to lungs in contrast to control tumors, though the formation of the bone and liver metastases was not affected. The selective disdavantage of these cells in lung colonization might result frem their inability to penetrate a vessel wall and underlying basement membrane in lung parenchyma. We targeted the specific aspects of tumor-endothelial cell intractions and demonstrated the capacity of transendothelial migration of the Myb-overexpressing MDA-MB-231 cells was impaired.The differential regulation of cytoskeleton dynamics and suppression of interstitial collagenase may contribute to the damaged extravasation and site-selective metastases of the Myb-overexpressing breast tumors.

Links

• CZ.1.07/2.3.00/20.0097, interní kód MU: Name: IntegRECAMO: Intellectual Anchor (Acronym: IntegRECAMO)

Investor: Ministry of Education, Youth and Sports of the CR, 2.3 Human resources in research and development

• NT13441, research and development project: Name: Exprese proteinů rodiny Myb v adenokarcinomech tlustého střeva a vztah k jejich metastatickému potenciálu