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@article{1106994,
author = {Attarbaschi, Andishe and Beishuizen, Auke and Mann, Georg and Rosolen, Angelo and Mori, Tetsuya and Uyttebroeck, Anne and Niggli, Felix and Csoka, Monika and Křenová, Zdenka and Mellgren, Karin and Kabickova, Edita and Chiang, Alan KS and Reiter, Alfred and Williams, Denise and Burkhardt, Birgit},
article_location = {Berlin},
article_number = {11},
doi = {http://dx.doi.org/10.1007/s00277-013-1785-2},
keywords = {"Watch and wait"; Complete resection; Follicular lymphoma; Outcome},
language = {eng},
issn = {0939-5555},
journal = {Annals of hematology},
title = {Children and adolescents with follicular lymphoma have an excellent prognosis with either limited chemotherapy or with a "watch and wait" strategy after complete resection},
volume = {92},
year = {2013}
}
TY - JOUR
ID - 1106994
AU - Attarbaschi, Andishe - Beishuizen, Auke - Mann, Georg - Rosolen, Angelo - Mori, Tetsuya - Uyttebroeck, Anne - Niggli, Felix - Csoka, Monika - Křenová, Zdenka - Mellgren, Karin - Kabickova, Edita - Chiang, Alan KS - Reiter, Alfred - Williams, Denise - Burkhardt, Birgit
PY - 2013
TI - Children and adolescents with follicular lymphoma have an excellent prognosis with either limited chemotherapy or with a "watch and wait" strategy after complete resection
JF - Annals of hematology
VL - 92
IS - 11
SP - 1537-1541
EP - 1537-1541
PB - Springer Verlag
SN - 09395555
KW - "Watch and wait"
KW - Complete resection
KW - Follicular lymphoma
KW - Outcome
N2 - Data on clinical features and outcome in pediatric follicular lymphoma (pFL) are scarce. The aim of this retrospective study including 13 EICNHL and/or i-BFM study group members was to assess clinical characteristics and course in a series of 63 pFL patients. pFL was found to be associated with male gender (3:1), older age (72 % >/- 10 years old), low serum LDH levels (<500 U/l in 75 %), grade 3 histology (in 88 %), and limited disease (87 % stage I/II disease), mostly involving the peripheral lymph nodes. Forty-four out of sixty-three patients received any polychemotherapy and 1/63 rituximab only, while 17/63 underwent a "watch and wait" strategy. Of 36 stage I patients, 30 had complete resections. Only one patient relapsed; 2-year event-free survival and overall survival were 94 +/- 5 and 100 %, respectively, after a median follow-up of 2.2 years. Conclusively, treatment outcome in pFL seems to be excellent with risk-adapted chemotherapy or after complete resection and an observational strategy only.
ER -
ATTARBASCHI, Andishe, Auke BEISHUIZEN, Georg MANN, Angelo ROSOLEN, Tetsuya MORI, Anne UYTTEBROECK, Felix NIGGLI, Monika CSOKA, Zdenka KŘENOVÁ, Karin MELLGREN, Edita KABICKOVA, Alan KS CHIANG, Alfred REITER, Denise WILLIAMS a Birgit BURKHARDT. Children and adolescents with follicular lymphoma have an excellent prognosis with either limited chemotherapy or with a ''watch and wait'' strategy after complete resection. \textit{Annals of hematology}. Berlin: Springer Verlag, 2013, roč.~92, č.~11, s.~1537-1541. ISSN~0939-5555. Dostupné z: https://dx.doi.org/10.1007/s00277-013-1785-2.
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