PŘIKRYL, Radovan and Hana PŘIKRYLOVÁ KUČEROVÁ. Can Repetitive Transcranial Magnetic Stimulation Be Considered Effective Treatment Option for Negative Symptoms of Schizophrenia? Journal of ECT, USA: Lippincott Williams and Wilkins, 2013, vol. 29, No 1, p. 67-74. ISSN 1095-0680. doi:10.1097/YCT.0b013e318270295f.
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Original name Can Repetitive Transcranial Magnetic Stimulation Be Considered Effective Treatment Option for Negative Symptoms of Schizophrenia?
Authors PŘIKRYL, Radovan (203 Czechia, guarantor, belonging to the institution) and Hana PŘIKRYLOVÁ KUČEROVÁ (203 Czechia, belonging to the institution).
Edition Journal of ECT, USA, Lippincott Williams and Wilkins, 2013, 1095-0680.
Other information
Original language English
Type of outcome article in a journal
Field of Study 30000 3. Medical and Health Sciences
Country of publisher United States of America
Confidentiality degree is not subject to a state or trade secret
Impact factor Impact factor: 1.387
RIV identification code RIV/00216224:14110/13:00068360
Organization unit Faculty of Medicine
Doi http://dx.doi.org/10.1097/YCT.0b013e318270295f
UT WoS 000315333000025
Keywords in English negative symptoms; schizophrenia; treatment; repetitive; transcranial magnetic stimulation; review
Tags International impact, Reviewed
Changed by Changed by: Ing. Mgr. Věra Pospíšilíková, učo 9005. Changed: 26/4/2014 11:42.
Abstract
Objective: Despite the development of second-generation antipsychotic drugs, treatment-resistant symptoms still represent a serious problem in schizophrenia. The aim of the present article was to review studies with repetitive transcranial magnetic stimulation for negative symptoms of schizophrenia and draw conclusions for clinical decision making. Method: Literature for this review was identified by searching MEDLINE and ISI Web of Science up to the year 2011. Results: Five open studies, 13 sham-controlled studies, and 2 metaanalysis and 2 review articles were included in the present paper. The effect size of the high frequency repetitive transcranial magnetic stimulation (rTMS) over the left prefrontal cortex in the treatment of negative symptoms of schizophrenia is thought to be mild to moderate (Cohen d = 0.43Y0.68). Conclusion: Despite the promising results of some rTMS studies, the potential of rTMS for the treatment of negative symptoms is currently relatively unclear. Large clinical studies are therefore needed, especially large multicentric studies such as depression rTMS studies. Clinical Recommendations: There is an evidence showing that rTMS can be considered the effective treatment option for negative symptoms of schizophrenia. Based on the results of current meta-analyses, the effect size of high-frequency rTMS in the treatment of negative symptoms of schizophrenia seems to be mild to moderate (Cohen d = 0.43Y0.63). Despite limited evidence base, the associations between efficacy and stimulation approaches (higher stimulation intensity, higher number of sessions or 10 Hz stimulus frequency) appear. Additional Comments: Neither the European Medicines Agency nor the Food and Drug Administration has approved rTMS for the treatment of negative symptoms of schizophrenia. Furthermore, large clinical studies are necessary to verify the natural benefit of rTMS for general clinical practice.
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