2013
Can Repetitive Transcranial Magnetic Stimulation Be Considered Effective Treatment Option for Negative Symptoms of Schizophrenia?
PŘIKRYL, Radovan a Hana PŘIKRYLOVÁ KUČEROVÁZákladní údaje
Originální název
Can Repetitive Transcranial Magnetic Stimulation Be Considered Effective Treatment Option for Negative Symptoms of Schizophrenia?
Autoři
PŘIKRYL, Radovan (203 Česká republika, garant, domácí) a Hana PŘIKRYLOVÁ KUČEROVÁ (203 Česká republika, domácí)
Vydání
Journal of ECT, USA, Lippincott Williams and Wilkins, 2013, 1095-0680
Další údaje
Jazyk
angličtina
Typ výsledku
Článek v odborném periodiku
Obor
30000 3. Medical and Health Sciences
Stát vydavatele
Spojené státy
Utajení
není předmětem státního či obchodního tajemství
Impakt faktor
Impact factor: 1.387
Kód RIV
RIV/00216224:14110/13:00068360
Organizační jednotka
Lékařská fakulta
UT WoS
000315333000025
Klíčová slova anglicky
negative symptoms; schizophrenia; treatment; repetitive; transcranial magnetic stimulation; review
Příznaky
Mezinárodní význam, Recenzováno
Změněno: 26. 4. 2014 11:42, Ing. Mgr. Věra Pospíšilíková
Anotace
V originále
Objective: Despite the development of second-generation antipsychotic drugs, treatment-resistant symptoms still represent a serious problem in schizophrenia. The aim of the present article was to review studies with repetitive transcranial magnetic stimulation for negative symptoms of schizophrenia and draw conclusions for clinical decision making. Method: Literature for this review was identified by searching MEDLINE and ISI Web of Science up to the year 2011. Results: Five open studies, 13 sham-controlled studies, and 2 metaanalysis and 2 review articles were included in the present paper. The effect size of the high frequency repetitive transcranial magnetic stimulation (rTMS) over the left prefrontal cortex in the treatment of negative symptoms of schizophrenia is thought to be mild to moderate (Cohen d = 0.43Y0.68). Conclusion: Despite the promising results of some rTMS studies, the potential of rTMS for the treatment of negative symptoms is currently relatively unclear. Large clinical studies are therefore needed, especially large multicentric studies such as depression rTMS studies. Clinical Recommendations: There is an evidence showing that rTMS can be considered the effective treatment option for negative symptoms of schizophrenia. Based on the results of current meta-analyses, the effect size of high-frequency rTMS in the treatment of negative symptoms of schizophrenia seems to be mild to moderate (Cohen d = 0.43Y0.63). Despite limited evidence base, the associations between efficacy and stimulation approaches (higher stimulation intensity, higher number of sessions or 10 Hz stimulus frequency) appear. Additional Comments: Neither the European Medicines Agency nor the Food and Drug Administration has approved rTMS for the treatment of negative symptoms of schizophrenia. Furthermore, large clinical studies are necessary to verify the natural benefit of rTMS for general clinical practice.