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@article{1113356, author = {Rabatinová, Alžbeta and Šanderová, Hana and Jirát Matějčková, Jitka and Korelusová, Jana and Sojka, Luděk and Barvík, Ivan and Papoušková, Veronika and Sklenář, Vladimír and Žídek, Lukáš and Krásný, Libor}, article_location = {Washington}, article_number = {11}, doi = {http://dx.doi.org/10.1128/JB.00188-13}, keywords = {RNA polymerase; delta subunit; regulation; nucleoside triphosphate; gene expression; cell survival}, language = {eng}, issn = {0021-9193}, journal = {Journal of Bacteriology}, title = {The Delta Subunit of RNA Polymerase Is Required for Rapid Changes in Gene Expression and Competitive Fitness of the Cell}, url = {http://jb.asm.org/content/195/11/2603.full}, volume = {195}, year = {2013} }
TY - JOUR ID - 1113356 AU - Rabatinová, Alžbeta - Šanderová, Hana - Jirát Matějčková, Jitka - Korelusová, Jana - Sojka, Luděk - Barvík, Ivan - Papoušková, Veronika - Sklenář, Vladimír - Žídek, Lukáš - Krásný, Libor PY - 2013 TI - The Delta Subunit of RNA Polymerase Is Required for Rapid Changes in Gene Expression and Competitive Fitness of the Cell JF - Journal of Bacteriology VL - 195 IS - 11 SP - 2603-2611 EP - 2603-2611 PB - American Society for Microbiology SN - 00219193 KW - RNA polymerase KW - delta subunit KW - regulation KW - nucleoside triphosphate KW - gene expression KW - cell survival UR - http://jb.asm.org/content/195/11/2603.full L2 - http://jb.asm.org/content/195/11/2603.full N2 - RNA polymerase (RNAP) is an extensively studied multisubunit enzyme required for transcription of DNA into RNA, yet the delta subunit of RNAP remains an enigmatic protein whose physiological roles have not been fully elucidated. Here, we identify a novel, so far unrecognized function of delta from Bacillus subtilis. We demonstrate that delta affects the regulation of RNAP by the concentration of the initiating nucleoside triphosphate ([iNTP]), an important mechanism crucial for rapid changes in gene expression in response to environmental changes. Consequently, we demonstrate that delta is essential for cell survival when facing a competing strain in a changing environment. Hence, although delta is not essential per se, it is vital for the cell's ability to rapidly adapt and survive in nature. Finally, we show that two other proteins, GreA and YdeB, previously implicated to affect regulation of RNAP by [iNTP] in other organisms, do not have this function in B. subtilis. ER -
RABATINOVÁ, Alžbeta, Hana ŠANDEROVÁ, Jitka JIRÁT MATĚJČKOVÁ, Jana KORELUSOVÁ, Luděk SOJKA, Ivan BARVÍK, Veronika PAPOUŠKOVÁ, Vladimír SKLENÁŘ, Lukáš ŽÍDEK a Libor KRÁSNÝ. The Delta Subunit of RNA Polymerase Is Required for Rapid Changes in Gene Expression and Competitive Fitness of the Cell. \textit{Journal of Bacteriology}. Washington: American Society for Microbiology, 2013, roč.~195, č.~11, s.~2603-2611. ISSN~0021-9193. Dostupné z: https://dx.doi.org/10.1128/JB.00188-13.
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