Cell cycle regulation in human embryonic stem cells: links to
adaptation to cell culture

J 2013

Cell cycle regulation in human embryonic stem cells: links to adaptation to cell culture

BÁRTA, Tomáš; Dáša DOLEŽALOVÁ; Zuzana HOLUBCOVÁ a Aleš HAMPL

Základní údaje

Originální název

Cell cycle regulation in human embryonic stem cells: links to adaptation to cell culture

Autoři

BÁRTA, Tomáš; Dáša DOLEŽALOVÁ; Zuzana HOLUBCOVÁ a Aleš HAMPL

Vydání

Experimental Biology and Medicine, LONDON, Mayvood, 2013, 1535-3702

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

Genetika a molekulární biologie

Stát vydavatele

Velká Británie a Severní Irsko

Utajení

není předmětem státního či obchodního tajemství

Impakt faktor

Impact factor: 2.226

Označené pro přenos do RIV

Ano

Kód RIV

RIV/00216224:14110/13:00066243

Organizační jednotka

Lékařská fakulta

DOI

https://doi.org/10.1177/1535370213480711

UT WoS

000318188900003

Klíčová slova anglicky

human embryonic stem cells; cell cycle; culture adaptation; long-term culture

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 6. 8. 2013 16:59, Ing. Mgr. Věra Pospíšilíková

Anotace

V originále

Cell cycle represents not only a tightly orchestrated mechanism of cell replication and cell division but it also plays an important role in regulation of cell fate decision. Particularly in the context of pluripotent stem cells or multipotent progenitor cells, regulation of cell fate decision is of paramount importance. It has been shown that human embryonic stem cells (hESCs) show unique cell cycle characteristics, such as short doubling time due to abbreviated G1 phase; these properties change with the onset of differentiation. This review summarizes the current understanding of cell cycle regulation in hESCs. We discuss cell cycle properties as well as regulatory machinery governing cell cycle progression of undifferentiated hESCs. Additionally, we provide evidence that long-term culture of hESCs is accompanied by changes in cell cycle properties as well as configuration of several cell cycle regulatory molecules.

Návaznosti

GAP301/10/1971, projekt VaV

Název: Exprese, signalizace a funkce receptorů smrti v lidských embryonálních kmenových buňkách.

Investor: Grantová agentura ČR, Exprese, signalizace a funkce receptorů smrti v lidských embryonálních kmenových buňkách

MSM0021622430, záměr

Název: Funkční a molekulární charakteristiky nádorových a normálních kmenových buněk - identifikace cílů pro nová terapeutika a terapeutické strategie

Investor: Ministerstvo školství, mládeže a tělovýchovy ČR, Funkční a molekulární charakteristiky nádorových a normálních kmenových buněk - identifikace cílů pro nová terapeutika a terapeutické strategie

Přiložené soubory

Barta.pdf

Požádat o autorskou verzi souboru

Citovat

BÁRTA, Tomáš; Dáša DOLEŽALOVÁ; Zuzana HOLUBCOVÁ a Aleš HAMPL. Cell cycle regulation in human embryonic stem cells: links to adaptation to cell culture. Experimental Biology and Medicine. LONDON: Mayvood, 2013, roč. 238, č. 3, s. 271-275. ISSN 1535-3702. Dostupné z: https://doi.org/10.1177/1535370213480711.

@article{1115210,
   author = {Bárta, Tomáš and Doležalová, Dáša and Holubcová, Zuzana and Hampl, Aleš},
   article_location = {LONDON},
   article_number = {3},
   doi = {https://doi.org/10.1177/1535370213480711},
   keywords = {human embryonic stem cells; cell cycle; culture adaptation; long-term culture},
   language = {eng},
   issn = {1535-3702},
   journal = {Experimental Biology and Medicine},
   title = {Cell cycle regulation in human embryonic stem cells: links to adaptation to cell culture},
   volume = {238},
   year = {2013}
}

TY  - JOUR
ID  - 1115210
AU  - Bárta, Tomáš - Doležalová, Dáša - Holubcová, Zuzana - Hampl, Aleš
PY  - 2013
TI  - Cell cycle regulation in human embryonic stem cells: links to adaptation to cell culture
JF  - Experimental Biology and Medicine
VL  - 238
IS  - 3
SP  - 271-275
EP  - 271-275
PB  - Mayvood
SN  - 15353702
KW  - human embryonic stem cells
KW  - cell cycle
KW  - culture adaptation
KW  - long-term culture
N2  - Cell cycle represents not only a tightly orchestrated mechanism of cell replication and cell division but it also plays an important role in regulation of cell fate decision. Particularly in the context of pluripotent stem cells or multipotent progenitor cells, regulation of cell fate decision is of paramount importance. It has been shown that human embryonic stem cells (hESCs) show unique cell cycle characteristics, such as short doubling time due to abbreviated G1 phase; these properties change with the onset of differentiation. This review summarizes the current understanding of cell cycle regulation in hESCs. We discuss cell cycle properties as well as regulatory machinery governing cell cycle progression of undifferentiated hESCs. Additionally, we provide evidence that long-term culture of hESCs is accompanied by changes in cell cycle properties as well as configuration of several cell cycle regulatory molecules.
ER  -

BÁRTA, Tomáš; Dáša DOLEŽALOVÁ; Zuzana HOLUBCOVÁ a Aleš HAMPL. Cell cycle regulation in human embryonic stem cells: links to adaptation to cell culture. \textit{Experimental Biology and Medicine}. LONDON: Mayvood, 2013, roč.~238, č.~3, s.~271-275. ISSN~1535-3702. Dostupné z: https://doi.org/10.1177/1535370213480711.

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