Synthesis, activity and interaction of nitrone functionalized PAH derivatives

POTÁČEK, Milan, Marian BUCHLOVIČ, Zdeněk KŘÍŽ and Ctirad HOFR. Synthesis, activity and interaction of nitrone functionalized PAH derivatives. 2013.

Basic information

• Original name: Synthesis, activity and interaction of nitrone functionalized PAH derivatives
• Authors: POTÁČEK, Milan (203 Czech Republic, guarantor, belonging to the institution), Marian BUCHLOVIČ (703 Slovakia), Zdeněk KŘÍŽ (203 Czech Republic, belonging to the institution) and Ctirad HOFR (203 Czech Republic).
• Edition: 2013.

Other information

• Original language: English
• Type of outcome: Requested lectures
• Field of Study: 10401 Organic chemistry
• Country of publisher: Latvia
• Confidentiality degree: is not subject to a state or trade secret
• RIV identification code: RIV/00216224:14310/13:00066251
• Organization unit: Faculty of Science
• Keywords in English: nitrone; PAH substitution; molecular modeling; activity testing in vitro

Abstract

Polycyclic aromatic hydrocarbons (PAHs) are widely studied. Their carcinogenic properties are well known. In a sharp contrast to those effects the functionalized PAHs were recently identified as important candidates for cancer therapy.1 Mechanism of action is often simplified and studied at the DNA level. A lot of discussion has been held about groups being introduced to the PAHs structure. Novel approach to functionalized polycyclic aromatic hydrocarbons (PAHs) is presented. According to our experience in nitrone chemistry2 the synthetic design of new PAHs derivatives was achieved by a multicomponent reaction of compounds 1-3.

Links

• GA203/09/1345, research and development project: Name: Allenový synthon v přípravě heterocyklických sloučenin

Investor: Czech Science Foundation, Allenyl synthon in synthesis of heterocyclic compounds