Functional neuroanatomy of vocalization in patients with
Parkinson's disease

J 2012

Functional neuroanatomy of vocalization in patients with Parkinson's disease

REKTOROVÁ, Irena, Michal MIKL, J. BARRETT, Radek MAREČEK, Ivan REKTOR et. al.

Základní údaje

Originální název

Functional neuroanatomy of vocalization in patients with Parkinson's disease

Autoři

REKTOROVÁ, Irena (203 Česká republika, garant, domácí), Michal MIKL (203 Česká republika, domácí), J. BARRETT (124 Kanada), Radek MAREČEK (203 Česká republika, domácí), Ivan REKTOR (203 Česká republika, domácí) a T. PAUS (124 Kanada)

Vydání

JOURNAL OF THE NEUROLOGICAL SCIENCES, AMSTERDAM, ELSEVIER SCIENCE BV, 2012, 0022-510X

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30000 3. Medical and Health Sciences

Stát vydavatele

Nizozemské království

Utajení

není předmětem státního či obchodního tajemství

Impakt faktor

Impact factor: 2.243

Kód RIV

RIV/00216224:14110/12:00068876

Organizační jednotka

Lékařská fakulta

DOI

http://dx.doi.org/10.1016/j.jns.2011.10.020

UT WoS

000299978800002

Klíčová slova anglicky

Parkinson's disease; Hypokinetic dysarthria; Speech production; Vocalization; fMRI; Functional connectivity; Periaqueductal gray matter; Auditory feedback

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 22. 7. 2013 14:42, Ing. Mgr. Věra Pospíšilíková

Anotace

V originále

In Parkinson's disease (PD) both speech production and self-monitoring of voiced speech are altered. Methods: In our previous study we used functional magnetic resonance imaging (fMRI) to examine which brain areas are involved in overt reading in nine female PD patients (mean age 66.0 +/- 11.6 years) compared with eight age-matched healthy female controls (mean age 62.2 years +/- 12.3). Here we performed the posthoc seed-based functional connectivity analysis of our data to assess the functional connectivity between the periaqueductal gray matter (PAG; i.e. the core subcortical structure involved in human vocalization) and other brain regions in the same groups of PD patients and controls. Results: In PD patients as compared with controls we observed increased connectivity between PAG and basal ganglia, posterior superior temporal gyrus, supramarginal and fusiform gyri and inferior parietal lobule on the right side. In the PD group, the connectivity strength in the right putamen and the right sypramarginal gyrus was correlated with variability of pitch while the connectivity strength in the right posterior superior temporal gyrus and in the right inferior parietal lobule was correlated with speech loudness. Conclusion: We observed functional reorganization in PD patients as compared with controls in both the motor basal ganglia-thalamo-cortical circuitry and cortical areas known to be engaged in-auditory and somatosensory feedback control of voiced speech. These changes were hemisphere-specific and might either reflect effects of dopaminergic treatment or at least partially successful compensatory mechanisms involved in early-stage PD.

Návaznosti

MSM0021622404, záměr

Název: Vnitřní organizace a neurobiologické mechanismy funkčních systémů CNS

Investor: Ministerstvo školství, mládeže a tělovýchovy ČR, Vnitřní organizace a neurobiologické mechanismy funkčních systémů CNS

Přiložené soubory

rektorova_functional.pdf

Požádat o autorskou verzi souboru

Citovat

REKTOROVÁ, Irena, Michal MIKL, J. BARRETT, Radek MAREČEK, Ivan REKTOR a T. PAUS. Functional neuroanatomy of vocalization in patients with Parkinson's disease. JOURNAL OF THE NEUROLOGICAL SCIENCES. AMSTERDAM: ELSEVIER SCIENCE BV, 2012, roč. 313, 1-2, s. 7-12. ISSN 0022-510X. Dostupné z: https://dx.doi.org/10.1016/j.jns.2011.10.020.

@article{1116679,
   author = {Rektorová, Irena and Mikl, Michal and Barrett, J. and Mareček, Radek and Rektor, Ivan and Paus, T.},
   article_location = {AMSTERDAM},
   article_number = {1-2},
   doi = {http://dx.doi.org/10.1016/j.jns.2011.10.020},
   keywords = {Parkinson's disease; Hypokinetic dysarthria; Speech production; Vocalization; fMRI; Functional connectivity; Periaqueductal gray matter; Auditory feedback},
   language = {eng},
   issn = {0022-510X},
   journal = {JOURNAL OF THE NEUROLOGICAL SCIENCES},
   title = {Functional neuroanatomy of vocalization in patients with Parkinson's disease},
   volume = {313},
   year = {2012}
}

TY  - JOUR
ID  - 1116679
AU  - Rektorová, Irena - Mikl, Michal - Barrett, J. - Mareček, Radek - Rektor, Ivan - Paus, T.
PY  - 2012
TI  - Functional neuroanatomy of vocalization in patients with Parkinson's disease
JF  - JOURNAL OF THE NEUROLOGICAL SCIENCES
VL  - 313
IS  - 1-2
SP  - 7-12
EP  - 7-12
PB  - ELSEVIER SCIENCE BV
SN  - 0022510X
KW  - Parkinson's disease
KW  - Hypokinetic dysarthria
KW  - Speech production
KW  - Vocalization
KW  - fMRI
KW  - Functional connectivity
KW  - Periaqueductal gray matter
KW  - Auditory feedback
N2  - In Parkinson's disease (PD) both speech production and self-monitoring of voiced speech are altered. Methods: In our previous study we used functional magnetic resonance imaging (fMRI) to examine which brain areas are involved in overt reading in nine female PD patients (mean age 66.0 +/- 11.6 years) compared with eight age-matched healthy female controls (mean age 62.2 years +/- 12.3). Here we performed the posthoc seed-based functional connectivity analysis of our data to assess the functional connectivity between the periaqueductal gray matter (PAG; i.e. the core subcortical structure involved in human vocalization) and other brain regions in the same groups of PD patients and controls. Results: In PD patients as compared with controls we observed increased connectivity between PAG and basal ganglia, posterior superior temporal gyrus, supramarginal and fusiform gyri and inferior parietal lobule on the right side. In the PD group, the connectivity strength in the right putamen and the right sypramarginal gyrus was correlated with variability of pitch while the connectivity strength in the right posterior superior temporal gyrus and in the right inferior parietal lobule was correlated with speech loudness. Conclusion: We observed functional reorganization in PD patients as compared with controls in both the motor basal ganglia-thalamo-cortical circuitry and cortical areas known to be engaged in-auditory and somatosensory feedback control of voiced speech. These changes were hemisphere-specific and might either reflect effects of dopaminergic treatment or at least partially successful compensatory mechanisms involved in early-stage PD.
ER  -

REKTOROVÁ, Irena, Michal MIKL, J. BARRETT, Radek MAREČEK, Ivan REKTOR a T. PAUS. Functional neuroanatomy of vocalization in patients with Parkinson's disease. \textit{JOURNAL OF THE NEUROLOGICAL SCIENCES}. AMSTERDAM: ELSEVIER SCIENCE BV, 2012, roč.~313, 1-2, s.~7-12. ISSN~0022-510X. Dostupné z: https://dx.doi.org/10.1016/j.jns.2011.10.020.

Podrobný výpis o publikaci