MicroRNAs targeting EGFR signalling pathway in colorectal
cancer

J 2013

MicroRNAs targeting EGFR signalling pathway in colorectal cancer

MLČOCHOVÁ, Jitka, Petra FALTEJSKOVÁ, Radim NĚMEČEK, Marek SVOBODA, Ondřej SLABÝ et. al.

Základní údaje

Originální název

MicroRNAs targeting EGFR signalling pathway in colorectal cancer

Autoři

MLČOCHOVÁ, Jitka (203 Česká republika, domácí), Petra FALTEJSKOVÁ (203 Česká republika, domácí), Radim NĚMEČEK (203 Česká republika, domácí), Marek SVOBODA (203 Česká republika, domácí) a Ondřej SLABÝ (203 Česká republika, garant, domácí)

Vydání

Journal of cancer research and clinical oncology, Springer-Verlag, 2013, 0171-5216

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30200 3.2 Clinical medicine

Stát vydavatele

Německo

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Impakt faktor

Impact factor: 3.009

Kód RIV

RIV/00216224:14740/13:00065617

Organizační jednotka

Středoevropský technologický institut

DOI

http://dx.doi.org/10.1007/s00432-013-1470-9

UT WoS

000324269200002

Klíčová slova anglicky

MicroRNA; Colorectal cancer; EGFR signalling pathway; Predictive biomarkers; Prognostic biomarkers

Štítky

rivok

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 8. 4. 2014 01:20, Olga Křížová

Anotace

V originále

MicroRNAs (miRNAs) are short, 18–25- nucleotide long, non-coding single-stranded RNAs, which are capable to regulate gene expression on post-transcrip- tional level through binding to their target protein-encoding mRNAs. miRNAs regulate individual components of multiple oncogenic pathways. One of them is epidermal growth factor receptor (EGFR) signalling pathway that regulates cell proliferation, differentiation, migration, angiogenesis and apoptosis. All these processes are deregulated in colorectal cancer (CRC). Moreover, EGFR has been validated as the therapeutic target in CRC, and monoclonal antibodies cetuximab and panitumumab are used in the therapy of patients with metastatic CRC. Because of the extensive involvement of miRNAs in the regulation of EGFR signalling, it seems they could also serve as promising predictive biomarkers to anti-EGFR therapy. In this review, we summarize current knowledge about miRNAs targeting EGFR signalling pathway, their functioning in CRC pathogenesis and potential usage as biomarkers.

Návaznosti

ED1.1.00/02.0068, projekt VaV

Název: CEITEC - central european institute of technology

NT13549, projekt VaV

Název: Vytvoření diagnostické sady cirkulujících mikroRNA pro neinvazivní časnou diagnostiku a sledování pacientů s kolorektálním karcinomem

Citovat

MLČOCHOVÁ, Jitka, Petra FALTEJSKOVÁ, Radim NĚMEČEK, Marek SVOBODA a Ondřej SLABÝ. MicroRNAs targeting EGFR signalling pathway in colorectal cancer. Journal of cancer research and clinical oncology. Springer-Verlag, 2013, roč. 139, č. 10, s. 1615-1624. ISSN 0171-5216. Dostupné z: https://dx.doi.org/10.1007/s00432-013-1470-9.

@article{1116739,
   author = {Mlčochová, Jitka and Faltejsková, Petra and Němeček, Radim and Svoboda, Marek and Slabý, Ondřej},
   article_number = {10},
   doi = {http://dx.doi.org/10.1007/s00432-013-1470-9},
   keywords = {MicroRNA; Colorectal cancer; EGFR signalling pathway; Predictive biomarkers; Prognostic biomarkers},
   language = {eng},
   issn = {0171-5216},
   journal = {Journal of cancer research and clinical oncology},
   title = {MicroRNAs targeting EGFR signalling pathway in colorectal cancer},
   url = {http://link.springer.com/article/10.1007%2Fs00432-013-1470-9},
   volume = {139},
   year = {2013}
}

TY  - JOUR
ID  - 1116739
AU  - Mlčochová, Jitka - Faltejsková, Petra - Němeček, Radim - Svoboda, Marek - Slabý, Ondřej
PY  - 2013
TI  - MicroRNAs targeting EGFR signalling pathway in colorectal cancer
JF  - Journal of cancer research and clinical oncology
VL  - 139
IS  - 10
SP  - 1615-1624
EP  - 1615-1624
PB  - Springer-Verlag
SN  - 01715216
KW  - MicroRNA
KW  - Colorectal cancer
KW  - EGFR signalling pathway
KW  - Predictive biomarkers
KW  - Prognostic biomarkers
UR  - http://link.springer.com/article/10.1007%2Fs00432-013-1470-9
L2  - http://link.springer.com/article/10.1007%2Fs00432-013-1470-9
N2  - MicroRNAs (miRNAs) are short, 18–25- nucleotide long, non-coding single-stranded RNAs, which are capable to regulate gene expression on post-transcrip- tional level through binding to their target protein-encoding mRNAs. miRNAs regulate individual components of multiple oncogenic pathways. One of them is epidermal growth factor receptor (EGFR) signalling pathway that regulates cell proliferation, differentiation, migration, angiogenesis and apoptosis. All these processes are deregulated in colorectal cancer (CRC). Moreover, EGFR has been validated as the therapeutic target in CRC, and monoclonal antibodies cetuximab and panitumumab are used in the therapy of patients with metastatic CRC. Because of the extensive involvement of miRNAs in the regulation of EGFR signalling, it seems they could also serve as promising predictive biomarkers to anti-EGFR therapy. In this review, we summarize current knowledge about miRNAs targeting EGFR signalling pathway, their functioning in CRC pathogenesis and potential usage as biomarkers.
ER  -

MLČOCHOVÁ, Jitka, Petra FALTEJSKOVÁ, Radim NĚMEČEK, Marek SVOBODA a Ondřej SLABÝ. MicroRNAs targeting EGFR signalling pathway in colorectal cancer. \textit{Journal of cancer research and clinical oncology}. Springer-Verlag, 2013, roč.~139, č.~10, s.~1615-1624. ISSN~0171-5216. Dostupné z: https://dx.doi.org/10.1007/s00432-013-1470-9.

Podrobný výpis o publikaci