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@article{1120449,
author = {Filip, Pavel and Lungu, Ovidiu V and Bareš, Martin},
article_location = {Clare},
article_number = {7},
doi = {http://dx.doi.org/10.1016/j.clinph.2013.01.003},
keywords = {Cerebellum; Dystonia; Animal models; Imaging; Pathophysiology},
language = {eng},
issn = {1388-2457},
journal = {Clinical Neurophysiology},
title = {Dystonia and the cerebellum: A new field of interest in movement disorders?},
url = {http://www.ncbi.nlm.nih.gov/pubmed/23422326},
volume = {124},
year = {2013}
}
TY - JOUR
ID - 1120449
AU - Filip, Pavel - Lungu, Ovidiu V - Bareš, Martin
PY - 2013
TI - Dystonia and the cerebellum: A new field of interest in movement disorders?
JF - Clinical Neurophysiology
VL - 124
IS - 7
SP - 1269-1276
EP - 1269-1276
PB - Elsevier Ireland
SN - 13882457
KW - Cerebellum
KW - Dystonia
KW - Animal models
KW - Imaging
KW - Pathophysiology
UR - http://www.ncbi.nlm.nih.gov/pubmed/23422326
L2 - http://www.ncbi.nlm.nih.gov/pubmed/23422326
N2 - Although dystonia has traditionally been regarded as a basal ganglia dysfunction, recent provocative evidence has emerged of cerebellar involvement in the pathophysiology of this enigmatic disease. This review synthesizes the data suggesting that the cerebellum plays an important role in dystonia etiology, from neuroanatomical research of complex networks showing that the cerebellum is connected to a wide range of other central nervous system structures involved in movement control to animal models indicating that signs of dystonia are due to cerebellum dysfunction and completely disappear after cerebellectomy, and finally to clinical observations in secondary dystonia patients with various types of cerebellar lesions. We propose that dystonia is a large-scale dysfunction, involving not only cortico-basal ganglia-thalamo-cortical pathways, but the cortico-ponto-cerebello-thalamo-cortical loop as well. Even in the absence of traditional "cerebellar signs" in most dystonia patients, there are more subtle indications of cerebellar dysfunction. It is clear that as long as the cerebellum's role in dystonia genesis remains unexamined, it will be difficult to significantly improve the current standards of dystonia treatment or to provide curative treatment.
ER -
FILIP, Pavel, Ovidiu V LUNGU a Martin BAREŠ. Dystonia and the cerebellum: A new field of interest in movement disorders? \textit{Clinical Neurophysiology}. Clare: Elsevier Ireland, 2013, roč.~124, č.~7, s.~1269-1276. ISSN~1388-2457. Dostupné z: https://dx.doi.org/10.1016/j.clinph.2013.01.003.
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