AREFIN, Badrul, Lucie KUČEROVÁ, Pavel DOBEŠ, Robert MARKUS, Hynek STRNAD, Zhi WANG, Pavel HYRŠL, Michal ŽUROVEC a Ulrich THEOPOLD. Genome-wide transcriptional analysis of Drosophila larvae infected by entomopathogenic nematodes shows involvement of complement, recognition and extracellular matrix proteins. Journal of Innate Immunity. Basel: Karger Publishers, 2014, roč. 6, č. 2, s. 192-204. ISSN 1662-811X. Dostupné z: https://dx.doi.org/10.1159/000353734. |
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@article{1121079, author = {Arefin, Badrul and Kučerová, Lucie and Dobeš, Pavel and Markus, Robert and Strnad, Hynek and Wang, Zhi and Hyršl, Pavel and Žurovec, Michal and Theopold, Ulrich}, article_location = {Basel}, article_number = {2}, doi = {http://dx.doi.org/10.1159/000353734}, keywords = {Basement membrane; Coagulation; Hemocyte; Insect immunity; Nematodes; Recognition molecule; Thioester-containing proteins}, language = {eng}, issn = {1662-811X}, journal = {Journal of Innate Immunity}, title = {Genome-wide transcriptional analysis of Drosophila larvae infected by entomopathogenic nematodes shows involvement of complement, recognition and extracellular matrix proteins}, url = {http://www.karger.com/Article/FullText/353734}, volume = {6}, year = {2014} }
TY - JOUR ID - 1121079 AU - Arefin, Badrul - Kučerová, Lucie - Dobeš, Pavel - Markus, Robert - Strnad, Hynek - Wang, Zhi - Hyršl, Pavel - Žurovec, Michal - Theopold, Ulrich PY - 2014 TI - Genome-wide transcriptional analysis of Drosophila larvae infected by entomopathogenic nematodes shows involvement of complement, recognition and extracellular matrix proteins JF - Journal of Innate Immunity VL - 6 IS - 2 SP - 192-204 EP - 192-204 PB - Karger Publishers SN - 1662811X KW - Basement membrane KW - Coagulation KW - Hemocyte KW - Insect immunity KW - Nematodes KW - Recognition molecule KW - Thioester-containing proteins UR - http://www.karger.com/Article/FullText/353734 L2 - http://www.karger.com/Article/FullText/353734 N2 - Heterorhabditis bacteriophora is an entomopathogenic nematode (EPN) which infects its host by accessing the hemolymph where it releases endosymbiotic bacteria of the species Photorhabdus luminescens. We performed a genome-wide transcriptional analysis of the Drosophila response to EPN infection at the time point at which the nematodes reached the hemolymph either via the cuticle or the gut and the bacteria had started to multiply. Many of the most strongly induced genes have been implicated in immune responses in other infection models. Mapping of the complete set of differentially regulated genes showed the hallmarks of a wound response, but also identified a large fraction of EPN-specific transcripts. Several genes identified by transcriptome profiling or their homologues play protective roles during nematode infections. Genes that positively contribute to controlling nematobacterial infections encode: a homolog of thioester-containing complement protein 3, a basement membrane component (glutactin), a recognition protein (GNBP-like 3) and possibly several small peptides. Of note is that several of these genes have not previously been implicated in immune responses. ER -
AREFIN, Badrul, Lucie KUČEROVÁ, Pavel DOBEŠ, Robert MARKUS, Hynek STRNAD, Zhi WANG, Pavel HYRŠL, Michal ŽUROVEC a Ulrich THEOPOLD. Genome-wide transcriptional analysis of Drosophila larvae infected by entomopathogenic nematodes shows involvement of complement, recognition and extracellular matrix proteins. \textit{Journal of Innate Immunity}. Basel: Karger Publishers, 2014, roč.~6, č.~2, s.~192-204. ISSN~1662-811X. Dostupné z: https://dx.doi.org/10.1159/000353734.
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