ŠMIŘÁKOVÁ, Eliška, Paride PAPADIA, Fabio ARNESANO, Giovanni NATILE, Karel KUBÍČEK and Jiří KOZELKA. Using NMR spectroscopy for improvement of cisplatin-based drugs. In Instruments and methods for biology and medicine 2011. 2011. ISBN 978-80-01-04915-0.
Other formats:   BibTeX LaTeX RIS
Basic information
Original name Using NMR spectroscopy for improvement of cisplatin-based drugs
Authors ŠMIŘÁKOVÁ, Eliška (203 Czech Republic, belonging to the institution), Paride PAPADIA (380 Italy), Fabio ARNESANO (380 Italy), Giovanni NATILE (380 Italy), Karel KUBÍČEK (203 Czech Republic, belonging to the institution) and Jiří KOZELKA (250 France, guarantor, belonging to the institution).
Edition Instruments and methods for biology and medicine 2011, 2011.
Other information
Original language English
Type of outcome Conference abstract
Field of Study 10610 Biophysics
Country of publisher Czech Republic
Confidentiality degree is not subject to a state or trade secret
RIV identification code RIV/00216224:14310/11:00069209
Organization unit Faculty of Science
ISBN 978-80-01-04915-0
Keywords (in Czech) cisplatina; nukleární magnetická rezonance; molekulárně-dynamické výpočty
Keywords in English cisplatin; nuclear magnetic resonance; molecular dynamics simulations
Tags International impact, Reviewed
Changed by Changed by: Mgr. Eliška Šmiřáková, učo 269953. Changed: 9/9/2013 10:35.
Abstract
One of the aims of the present research is the development of new anticancer drugs by modifying the already known ones to increase their cytostatic activity while lowering the side-effects. The major goal of this project is to investigate the sequence selectivity of cisplatin-DNA interaction in order to understand the biochemical mechanism of cisplatin effect and consider the way to reduce its toxicity. To achieve this goal, we employed modern NMR methods, taking so the advantage of the fact that it is possible to study the biological compounds of interest in solution under nearly physiological conditions. In my contribution, I will show the structural properties of DNA 22-mer containing T4-loop crosslinked with cisplatin derivative RR-DACH. NMR data acquisition and processing as well as the determination of the structural models using molecular dynamics simulations will be presented.
Links
MUNI/A/1046/2009, interní kód MUName: Biofyzikální výzkum struktur a funkcí biomolekul (Acronym: BVSFB)
Investor: Masaryk University, Category A
PrintDisplayed: 28/4/2024 16:29