| TE RAA, G. Doreen, Jitka MALČÍKOVÁ, Šárka POSPÍŠILOVÁ, Martin TRBUŠEK, Marek MRÁZ, Maria LE GARFF-TAVERNIER, Helene MERLE-BERAL, Ke LIN, Andrew R. PETTITT, Olaf MERKEL, Tatjana STANKOVIC, Marinus H. VAN OERS, Eric ELDERING, Stephan STILGENBAUER, Thorsten ZENZ a Arnon P. KATER. Overview of available p53 function tests in relation to TP53 and ATM gene alterations and chemoresistance in chronic lymphocytic leukemia. Leukemia & Lymphoma. London: Informa Healthcare, 2013, roč. 54, č. 8, s. 1849-1853. ISSN 1042-8194. Dostupné z: https://dx.doi.org/10.3109/10428194.2013.796058. |
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@article{1121854,
author = {te Raa, G. Doreen and Malčíková, Jitka and Pospíšilová, Šárka and Trbušek, Martin and Mráz, Marek and Le GarffandTavernier, Maria and MerleandBeral, Helene and Lin, Ke and Pettitt, Andrew R. and Merkel, Olaf and Stankovic, Tatjana and van Oers, Marinus H. and Eldering, Eric and Stilgenbauer, Stephan and Zenz, Thorsten and Kater, Arnon P.},
article_location = {London},
article_number = {8},
doi = {http://dx.doi.org/10.3109/10428194.2013.796058},
keywords = {chronic lymphocytic leukemia; DNA damage response; p53 function assays; p53 axis; TP53; ATM},
language = {eng},
issn = {1042-8194},
journal = {Leukemia & Lymphoma},
title = {Overview of available p53 function tests in relation to TP53 and ATM gene alterations and chemoresistance in chronic lymphocytic leukemia},
volume = {54},
year = {2013}
}
TY - JOUR
ID - 1121854
AU - te Raa, G. Doreen - Malčíková, Jitka - Pospíšilová, Šárka - Trbušek, Martin - Mráz, Marek - Le Garff-Tavernier, Maria - Merle-Beral, Helene - Lin, Ke - Pettitt, Andrew R. - Merkel, Olaf - Stankovic, Tatjana - van Oers, Marinus H. - Eldering, Eric - Stilgenbauer, Stephan - Zenz, Thorsten - Kater, Arnon P.
PY - 2013
TI - Overview of available p53 function tests in relation to TP53 and ATM gene alterations and chemoresistance in chronic lymphocytic leukemia
JF - Leukemia & Lymphoma
VL - 54
IS - 8
SP - 1849-1853
EP - 1849-1853
PB - Informa Healthcare
SN - 10428194
KW - chronic lymphocytic leukemia
KW - DNA damage response
KW - p53 function assays
KW - p53 axis
KW - TP53
KW - ATM
N2 - The ATM-p53 DNA damage response pathway plays a crucial role in chemoresistance in chronic lymphocytic leukemia, as indicated by the adverse prognostic impact of deletions of 17p (locus of TP53) and 11q (locus of ATM) detected by fluorescence in situ hybridization (FISH) analysis. In addition to deletions, mutations in these respective genes are also associated with chemoresistance, and add to the prognostic information provided by FISH. In order to explore the possibility that dysfunction of the ATM-p53 pathway might also result from mechanisms other than ATM/TP53 deletion/mutation, assays have been developed that probe the functional integrity of the ATM-p53 pathway. Currently, four different p53 function assays have been developed that are based on the measurement of p53 and p53-dependent genes at the RNA (real-time polymerase chain reaction [RT-PCR]p21; RT-PCRmiR34a; reverse transcription-multiplex ligation-dependent probe amplification assay [RT-MLPA]p21, bax, puma and CD95) or protein (fluorescence activated cell sorting [FACS]p53-p21) level in untreated cells or following irradiation or drug treatment. Here we provide an overview of these assays based on the available literature.
ER -
TE RAA, G. Doreen, Jitka MALČÍKOVÁ, Šárka POSPÍŠILOVÁ, Martin TRBUŠEK, Marek MRÁZ, Maria LE GARFF-TAVERNIER, Helene MERLE-BERAL, Ke LIN, Andrew R. PETTITT, Olaf MERKEL, Tatjana STANKOVIC, Marinus H. VAN OERS, Eric ELDERING, Stephan STILGENBAUER, Thorsten ZENZ a Arnon P. KATER. Overview of available p53 function tests in relation to TP53 and ATM gene alterations and chemoresistance in chronic lymphocytic leukemia. \textit{Leukemia \&{} Lymphoma}. London: Informa Healthcare, 2013, roč.~54, č.~8, s.~1849-1853. ISSN~1042-8194. Dostupné z: https://dx.doi.org/10.3109/10428194.2013.796058.
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