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@proceedings{1121860,
author = {Kozáková, Lucie and Bednářová, Kateřina and Hudson, Jessica and Guérineau, Marc and Lehmann, Alan and Paleček, Jan},
booktitle = {The 19th International chromosome conference},
keywords = {SMC 5/6 complex, non-SMC subunits, MAGE proteins, EID proteins},
title = {Evolution and function of non-SMC subunits of SMC5/6 complex},
year = {2013}
}
TY - CONF
ID - 1121860
AU - Kozáková, Lucie - Bednářová, Kateřina - Hudson, Jessica - Guérineau, Marc - Lehmann, Alan - Paleček, Jan
PY - 2013
TI - Evolution and function of non-SMC subunits of SMC5/6 complex
KW - SMC 5/6 complex, non-SMC subunits, MAGE proteins, EID proteins
N2 - Structural Maintenance of Chromosomes (SMC) proteins are highly conserved from bacteria to humans and play fundamental roles in chromosome dynamics, gene regulation and DNA repair. SMC1/3 (cohesin) complex is involved in sister chromatid cohesion, SMC2/4 (condensin) contributes to chromosome condensation and SMC5/6 complex is involved in several DNA repair pathways. SMC5/6 heterodimer associates with four non-SMC elements (Nse). The human Nse3 ortholog MAGEG1, founding member of MAGE (Melanoma Antigen Gene) protein family, interacts with both NSE1 (RING-finger containing protein) and NSE4 subunits. The NSE1-MAGEG1-NSE4 subcomplex bridges the head domains of Smc5-Smc6 heterodimer. In our work we have determined interacting domains of Nse3/MAGEG1 and Nse4/EID proteins. The conservation of interacting surface suggests their tight co-evolution. Functional analysis showed involvement of both protein families in transcription regulation and uncovered one possible function of enigmatic MAGE proteins.
ER -
KOZÁKOVÁ, Lucie, Kateřina BEDNÁŘOVÁ, Jessica HUDSON, Marc GUÉRINEAU, Alan LEHMANN and Jan PALEČEK. Evolution and function of non-SMC subunits of SMC5/6 complex. In \textit{The 19th International chromosome conference}. 2013.
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