Acoustic evaluation of short-term effects of repetitive
transcranial magnetic stimulation on motor aspects of speech in
Parkinson's disease

J 2013

Acoustic evaluation of short-term effects of repetitive transcranial magnetic stimulation on motor aspects of speech in Parkinson's disease

ELIÁŠOVÁ, Ilona, J. MEKYSKA, Milena KOŠŤÁLOVÁ, Radek MAREČEK, Z. SMEKAL et. al.

Základní údaje

Originální název

Acoustic evaluation of short-term effects of repetitive transcranial magnetic stimulation on motor aspects of speech in Parkinson's disease

Autoři

ELIÁŠOVÁ, Ilona (203 Česká republika, domácí), J. MEKYSKA (203 Česká republika), Milena KOŠŤÁLOVÁ (203 Česká republika, domácí), Radek MAREČEK (203 Česká republika, domácí), Z. SMEKAL (203 Česká republika) a Irena REKTOROVÁ (203 Česká republika, garant, domácí)

Vydání

Journal of Neural Transmission, Vídeň, SPRINGER WIEN, 2013, 0300-9564

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30000 3. Medical and Health Sciences

Stát vydavatele

Rakousko

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Impakt faktor

Impact factor: 2.871

Kód RIV

RIV/00216224:14740/13:00065624

Organizační jednotka

Středoevropský technologický institut

DOI

http://dx.doi.org/10.1007/s00702-012-0953-1

UT WoS

000317076600015

Klíčová slova anglicky

Hypokinetic dysarthria; Parkinson's disease; rTMS; Acoustic evaluation

Štítky

ok, rivok

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 13. 9. 2013 13:22, Olga Křížová

Anotace

V originále

Hypokinetic dysarthria in Parkinson's disease (PD) can be characterized by monotony of pitch and loudness, reduced stress, variable rate, imprecise consonants, and a breathy and harsh voice. Using acoustic analysis, we studied the effects of high-frequency repetitive transcranial magnetic stimulation (rTMS) applied over the primary orofacial sensorimotor area (SM1) and the left dorsolateral prefrontal cortex (DLPFC) on motor aspects of voiced speech in PD. Twelve non-depressed and non-demented men with PD (mean age 64.58 +/- A 8.04 years, mean PD duration 10.75 +/- A 7.48 years) and 21 healthy age-matched men (a control group, mean age 64 +/- A 8.55 years) participated in the speech study. The PD patients underwent two sessions of 10 Hz rTMS over the dominant hemisphere with 2,250 stimuli/day in a random order: (1) over the SM1; (2) over the left DLPFC in the "on" motor state. Speech examination comprised the perceptual rating of global speech performance and an acoustic analysis based upon a standardized speech task. The Mann-Whitney U test was used to compare acoustic speech variables between controls and PD patients. The Wilcoxon test was used to compare data prior to and after each stimulation in the PD group. rTMS applied over the left SM1 was associated with a significant increase in harmonic-to-noise ratio and net speech rate in the sentence tasks. With respect to the vowel task results, increased median values and range of Teager-Kaiser energy operator, increased vowel space area, and significant jitter decrease were observed after the left SM1 stimulation. rTMS over the left DLPFC did not induce any significant effects. The positive results of acoustic analysis were not reflected in a subjective rating of speech performance quality as assessed by a speech therapist. Our pilot results indicate that one session of rTMS applied over the SM1 may lead to measurable improvement in voice quality and intensity and an increase in speech rate and tongue movements. Nevertheless, these changes were not accompanied by changes in a perceptual evaluation of speech performance by a speech therapist. Future placebo-controlled studies in larger patient cohorts should verify if rTMS would be clinically useful for treating hypokinetic dysarthria in PD.

Návaznosti

ED1.1.00/02.0068, projekt VaV

Název: CEITEC - central european institute of technology

NT13499, projekt VaV

Název: Řeč, její poruchy a kognitivní funkce u Parkinsonovy nemoci

Citovat

ELIÁŠOVÁ, Ilona, J. MEKYSKA, Milena KOŠŤÁLOVÁ, Radek MAREČEK, Z. SMEKAL a Irena REKTOROVÁ. Acoustic evaluation of short-term effects of repetitive transcranial magnetic stimulation on motor aspects of speech in Parkinson's disease. Journal of Neural Transmission. Vídeň: SPRINGER WIEN, 2013, roč. 120, č. 4, s. 597-605. ISSN 0300-9564. Dostupné z: https://dx.doi.org/10.1007/s00702-012-0953-1.

@article{1121982,
   author = {Eliášová, Ilona and Mekyska, J. and Košťálová, Milena and Mareček, Radek and Smekal, Z. and Rektorová, Irena},
   article_location = {Vídeň},
   article_number = {4},
   doi = {http://dx.doi.org/10.1007/s00702-012-0953-1},
   keywords = {Hypokinetic dysarthria; Parkinson's disease; rTMS; Acoustic evaluation},
   language = {eng},
   issn = {0300-9564},
   journal = {Journal of Neural Transmission},
   title = {Acoustic evaluation of short-term effects of repetitive transcranial magnetic stimulation on motor aspects of speech in Parkinson's disease},
   url = {http://link.springer.com/article/10.1007%2Fs00702-012-0953-1},
   volume = {120},
   year = {2013}
}

TY  - JOUR
ID  - 1121982
AU  - Eliášová, Ilona - Mekyska, J. - Košťálová, Milena - Mareček, Radek - Smekal, Z. - Rektorová, Irena
PY  - 2013
TI  - Acoustic evaluation of short-term effects of repetitive transcranial magnetic stimulation on motor aspects of speech in Parkinson's disease
JF  - Journal of Neural Transmission
VL  - 120
IS  - 4
SP  - 597-605
EP  - 597-605
PB  - SPRINGER WIEN
SN  - 03009564
KW  - Hypokinetic dysarthria
KW  - Parkinson's disease
KW  - rTMS
KW  - Acoustic evaluation
UR  - http://link.springer.com/article/10.1007%2Fs00702-012-0953-1
L2  - http://link.springer.com/article/10.1007%2Fs00702-012-0953-1
N2  - Hypokinetic dysarthria in Parkinson's disease (PD) can be characterized by monotony of pitch and loudness, reduced stress, variable rate, imprecise consonants, and a breathy and harsh voice. Using acoustic analysis, we studied the effects of high-frequency repetitive transcranial magnetic stimulation (rTMS) applied over the primary orofacial sensorimotor area (SM1) and the left dorsolateral prefrontal cortex (DLPFC) on motor aspects of voiced speech in PD. Twelve non-depressed and non-demented men with PD (mean age 64.58 +/- A 8.04 years, mean PD duration 10.75 +/- A 7.48 years) and 21 healthy age-matched men (a control group, mean age 64 +/- A 8.55 years) participated in the speech study. The PD patients underwent two sessions of 10 Hz rTMS over the dominant hemisphere with 2,250 stimuli/day in a random order: (1) over the SM1; (2) over the left DLPFC in the "on" motor state. Speech examination comprised the perceptual rating of global speech performance and an acoustic analysis based upon a standardized speech task. The Mann-Whitney U test was used to compare acoustic speech variables between controls and PD patients. The Wilcoxon test was used to compare data prior to and after each stimulation in the PD group. rTMS applied over the left SM1 was associated with a significant increase in harmonic-to-noise ratio and net speech rate in the sentence tasks. With respect to the vowel task results, increased median values and range of Teager-Kaiser energy operator, increased vowel space area, and significant jitter decrease were observed after the left SM1 stimulation. rTMS over the left DLPFC did not induce any significant effects. The positive results of acoustic analysis were not reflected in a subjective rating of speech performance quality as assessed by a speech therapist. Our pilot results indicate that one session of rTMS applied over the SM1 may lead to measurable improvement in voice quality and intensity and an increase in speech rate and tongue movements. Nevertheless, these changes were not accompanied by changes in a perceptual evaluation of speech performance by a speech therapist. Future placebo-controlled studies in larger patient cohorts should verify if rTMS would be clinically useful for treating hypokinetic dysarthria in PD.
ER  -

ELIÁŠOVÁ, Ilona, J. MEKYSKA, Milena KOŠŤÁLOVÁ, Radek MAREČEK, Z. SMEKAL a Irena REKTOROVÁ. Acoustic evaluation of short-term effects of repetitive transcranial magnetic stimulation on motor aspects of speech in Parkinson's disease. \textit{Journal of Neural Transmission}. Vídeň: SPRINGER WIEN, 2013, roč.~120, č.~4, s.~597-605. ISSN~0300-9564. Dostupné z: https://dx.doi.org/10.1007/s00702-012-0953-1.

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