NAVRÁTILOVÁ, Jarmila, Tereza HANKEOVÁ, Petr BENEŠ a Jan ŠMARDA. Acidic pH of tumor microenvironment enhances cytotoxicity of disulfiram/Cu2+ complex to breast and colon cancer cells. CHEMOTHERAPY. Basel, Switzerland: S. KARGER AG, Basel, 2013, roč. 2013, č. 59, s. 112-120. ISSN 0009-3157. Dostupné z: https://dx.doi.org/10.1159/000353915. |
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@article{1122524, author = {Navrátilová, Jarmila and Hankeová, Tereza and Beneš, Petr and Šmarda, Jan}, article_location = {Basel, Switzerland}, article_number = {59}, doi = {http://dx.doi.org/10.1159/000353915}, keywords = {Breast cancer; Colon cancer; Cytotoxicity; Disulfiram; Reactive Oxygen Species; Tumor microenvironment}, language = {eng}, issn = {0009-3157}, journal = {CHEMOTHERAPY}, title = {Acidic pH of tumor microenvironment enhances cytotoxicity of disulfiram/Cu2+ complex to breast and colon cancer cells}, volume = {2013}, year = {2013} }
TY - JOUR ID - 1122524 AU - Navrátilová, Jarmila - Hankeová, Tereza - Beneš, Petr - Šmarda, Jan PY - 2013 TI - Acidic pH of tumor microenvironment enhances cytotoxicity of disulfiram/Cu2+ complex to breast and colon cancer cells JF - CHEMOTHERAPY VL - 2013 IS - 59 SP - 112-120 EP - 112-120 PB - S. KARGER AG, Basel SN - 00093157 KW - Breast cancer KW - Colon cancer KW - Cytotoxicity KW - Disulfiram KW - Reactive Oxygen Species KW - Tumor microenvironment N2 - A resistance of cancer cells to chemotherapeutic agents is a major cause of treatment failure in patients with cancer. The drug-resistance of tumor cells can be significantly modified by specific features of tumor microenvironment, such as oxygen depletion (hypoxia), glucose/energy deprivation and acidosis. The effects of acidic tumor-like microenvironment on cytotoxicity of antabuse (disulfiram)/Cu2+ complexes to MCF-7 breast carcinoma and HT-29 colon carcinoma cells were studied. We show that acidic pH significantly potentiates toxicity of disulfiram/Cu2+ complex to breast and colon cancer cells. This phenomenon is associated with changes in cell metabolism, altered Akt kinase and NFkappaB activities and increased reactive oxygen species production. Conclusion: Specific pH of tumor microenvironment enhances cytotoxicity of disulfiram/Cu2+ to breast and colon cancer cells. ER -
NAVRÁTILOVÁ, Jarmila, Tereza HANKEOVÁ, Petr BENEŠ a Jan ŠMARDA. Acidic pH of tumor microenvironment enhances cytotoxicity of disulfiram/Cu2+ complex to breast and colon cancer cells. \textit{CHEMOTHERAPY}. Basel, Switzerland: S. KARGER AG, Basel, 2013, roč.~2013, č.~59, s.~112-120. ISSN~0009-3157. Dostupné z: https://dx.doi.org/10.1159/000353915.
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