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@article{1122863,
author = {Bébarová, Markéta},
article_location = {Amsterdam},
article_number = {5},
doi = {http://dx.doi.org/10.1016/j.ijcard.2012.12.019},
keywords = {Arrhythmogenesis; Atrial fibrillation; Brugada syndrome; Discontinuous conduction; Dysfunction; Mutation},
language = {eng},
issn = {0167-5273},
journal = {International Journal of Cardiology},
title = {Arrhythmogenesis in Brugada syndrome: Impact and constrains of current concepts},
volume = {167},
year = {2013}
}
TY - JOUR
ID - 1122863
AU - Bébarová, Markéta
PY - 2013
TI - Arrhythmogenesis in Brugada syndrome: Impact and constrains of current concepts
JF - International Journal of Cardiology
VL - 167
IS - 5
SP - 1760-1771
EP - 1760-1771
PB - Elsevier
SN - 01675273
KW - Arrhythmogenesis
KW - Atrial fibrillation
KW - Brugada syndrome
KW - Discontinuous conduction
KW - Dysfunction
KW - Mutation
N2 - Brugada syndrome (BrS), an inherited arrhythmogenic disease first described in 1992, is characterized by ST segment elevations on the electrocardiogram in the right precordium and by a high occurrence of arrhythmias including the life-threatening ventricular tachycardia/fibrillation. Knowledge of the underlying mechanisms of formation of arrhythmogenic substrate in BrS is essential, namely for the risk stratification of BrS patients and their therapy which is still restrained almost exclusively to the implantation of cardioverter/defibrillator. In spite of many crucial findings in this field published within recent years, the final consistent view has not been established so far. Hence, BrS described 20 years ago remains an actual topic of both clinical and experimental studies. This review presents an overview of the current knowledge related to the pathogenesis of BrS arrhythmogenic substrate, namely of the genetic basis of BrS, functional consequences of mutations related to BrS, and arrhythmogenic mechanisms in BrS.
ER -
BÉBAROVÁ, Markéta. Arrhythmogenesis in Brugada syndrome: Impact and constrains of current concepts. \textit{International Journal of Cardiology}. Amsterdam: Elsevier, 2013, roč.~167, č.~5, s.~1760-1771. ISSN~0167-5273. Dostupné z: https://dx.doi.org/10.1016/j.ijcard.2012.12.019.
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